Myocardial tolerance to ischemia-reperfusion injury, training intensity and cessation

European Journal of Applied Physiology

Volumn 111, Issue 5, 2011, Pages 859-868

  Esposito, Fabio ^a   Ronchi, Raffaella ^a   Milano, Giuseppina ^b   Margonato, Vittoria ^a   Di Tullio, Simona ^c   Marini, Marina ^c   Veicsteinas, Arsenio ^a,d   Samaja, Michele ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Cardioprotection; Exercise; HSP70; Mn SOD; VEGF

Indexed keywords

HEAT SHOCK PROTEIN 70; SUPEROXIDE DISMUTASE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; HEART MUSCLE; MALE; METABOLISM; PHYSIOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; HSP70 HEAT-SHOCK PROTEINS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 79958768583     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1707-0     Document Type: Article

References (41)

1. Armstrong RB, Laughlin MH, Rome L, Taylor CR (1983) Metabolism of rats running up and down an incline. J Appl Physiol 55:518-521 (Pubitemid 13044082)
2. Benjamin I, Christians E (2002) Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. Circ Res 90:833-835 (Pubitemid 34633871)
3. Boluyt MO, Brevick JL, Rogers DS, Randall MJ, Scalia AF, Li ZB (2006) Changes in the rat heart proteome induced by exercise training: increased abundance of heat shock protein hsp20. Proteomics 6:3154-3169 (Pubitemid 43806411)
4. Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, Graf C, Latsch J, Montie GL, Prede GL, Bloch W (2008) Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years. Br J Sports Med 42:126-129 (discussion 129) (Pubitemid 351271226)
5. Brown MD (2003) Exercise and coronary vascular remodelling in the healthy heart. Exp Physiol 88:645-658 (Pubitemid 37121739)
6. Brown DA, Moore RL (2007) Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise. J Appl Physiol 103:1894-1899 (Pubitemid 350033878)
7. Chicco AJ, Johnson MS, Armstrong CJ, Lynch JM, Gardner RT, Fasen GS, Gillenwater CP, Moore RL (2007) Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart. Am J Physiol Heart Circ Physiol 292:H2432-H2437 (Pubitemid 47084626)
8. Demirel HA, Powers SK, Zergeroglu MA, Shanely RA, Hamilton K, Coombes J, Naito H (2001) Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol 91:2205-2212 (Pubitemid 33015075)
9. Demirel HA, Hamilton KL, Shanely RA, Tumer N, Koroly MJ, Powers SK (2003) Age and attenuation of exercise-induced myocardial HSP72 accumulation. Am J Physiol Heart Circ Physiol 285:H1609-H1615 (Pubitemid 37169516)
10. Dickson EW, Hogrefe CP, Ludwig PS, Ackermann LW, Stoll LL, Denning GM (2008) Exercise enhances myocardial ischemic tolerance via an opioid receptor-dependent mechanism. Am J Physiol Heart Circ Physiol 294:H402-H408
11. French JP, Hamilton KL, Quindry JC, Lee Y, Upchurch PA, Powers SK (2008) Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpain. FASEB J 22:2862-2871
12. Hamilton KL, Powers SK, Sugiura T, Kim S, Lennon S, Tumer N, Mehta JL (2001) Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins. Am J Physiol Heart Circ Physiol 281:H1346-H1352
13. Hamilton KL, Staib JL, Phillips T, Hess A, Lennon SL, Powers SK (2003) Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Free Radic Biol Med 34:800-809 (Pubitemid 36316063)
14. Harris MB, Starnes JW (2001) Effects of body temperature during exercise training on myocardial adaptations. Am J Physiol Heart Circ Physiol 280:H2271-H2280
15. Husain K (2004) Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension. Biochem Biophys Res Commun 320:1169-1174 (Pubitemid 38916666)
16. Kavazis AN, McClung JM, Hood DA, Powers SK (2008) Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli. Am J Physiol Heart Circ Physiol 294:H928-H935 (Pubitemid 351253305)
17. Kemi OJ, Haram PM, Loennechen JP, Osnes JB, Skomedal T, Wisloff U, Ellingsen O (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res 67:161-172 (Pubitemid 40798303)
18. Laughlin MH, Oltman CL, Bowles DK (1998) Exercise traininginduced adaptations in the coronary circulation. Med Sci Sports Exerc 30:352-360 (Pubitemid 28120233)
19. Lennon SL, Quindry J, Hamilton KL, French J, Staib J, Mehta JL, Powers SK (2004a) Loss of exercise-induced cardioprotection after cessation of exercise. J Appl Physiol 96:1299-1305 (Pubitemid 38392664)
20. Lennon SL, Quindry JC, French JP, Kim S, Mehta JL, Powers SK (2004b) Exercise and myocardial tolerance to ischaemia-reperfusion. Acta Physiol Scand 182:161-169 (Pubitemid 39371863)
21. Liu J, Yeo H, Overvik-Douki E, Hagen T, Doniger S, Chu D, Brooks G, Ames B (2000) Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol 89:21-28 (Pubitemid 30482559)
22. Marini M, Frabetti F, Musiani D, Franceschi C (1996) Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. Int J Radiat Biol 70(3):337-350 (Pubitemid 26294841)
23. Marini M, Lapalombella R, Margonato V, Ronchi R, Samaja M, Scapin C, Gorza L, Maraldi T, Carinci P, Ventura C, Veicsteinas A (2007) Mild exercise training, cardioprotection and stress genes profile. Eur J Appl Physiol 99:503-510 (Pubitemid 46766843)
24. Marini M, Falcieri E, Margonato V, Trere D, Lapalombella R, di Tullio S, Marchionni C, Burattini S, Samaja M, Esposito F, Veicsteinas A (2008) Partial persistence of exercise-induced myocardial angiogenesis following 4-week detraining in the rat. Histochem Cell Biol 129:479-487
25. Melling CW, Thorp DB, Milne KJ, Noble EG (2009) Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise. Cell Stress Chaperones 14:141-150
26. Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I (2008) Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia 51:1327-1337
27. Pantos C, Malliopoulou V, Mourouzis I, Thempeyioti A, Paizis I, Dimopoulos A, Saranteas T, Xinaris C, Cokkinos DV (2006) Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70. Horm Metab Res 38:308-313 (Pubitemid 43864951)
28. Paroo Z, Haist JV, Karmazyn M, Noble EG (2002) Exercise improves postischemic cardiac function in males but not females: consequences of a novel sex-specific heat shock protein 70 response. Circ Res 90:911-917 (Pubitemid 34633884)
29. Powers SK, Lennon SL, Quindry J, Mehta JL (2002) Exercise and cardioprotection. Curr Opin Cardiol 17:495-502 (Pubitemid 35265787)
30. Powers SK, Quindry JC, Kavazis AN (2008) Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med 44:193-201
31. Quindry J, French J, Hamilton K, Lee Y, Mehta JL, Powers S (2005) Exercise training provides cardioprotection against ischemiareperfusion induced apoptosis in young and old animals. Exp Gerontol 40:416-425 (Pubitemid 40775735)
32. Quindry JC, Hamilton KL, French JP, Lee Y, Murlasits Z, Tumer N, Powers SK (2007) Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis. J Appl Physiol 103:1056-1062 (Pubitemid 47358893)
33. Staib JL, Quindry JC, French JP, Criswell DS, Powers SK (2007) Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart. Am J Physiol Regul Integr Comp Physiol 292:R432-R439 (Pubitemid 46089858)
34. Starnes JW, Taylor RP, Park Y (2003) Exercise improves postischemic function in aging hearts. Am J Physiol Heart Circ Physiol 285:H347-H351 (Pubitemid 36736448)
35. 2+-induced dysfunction. J Appl Physiol 102:1793-1798 (Pubitemid 46701946)
36. Tarricone E, Scapin C, Vitadello M, Esposito F, Margonato V, Milano G, Samaja M, Gorza L (2008) Cellular distribution of Hsp70 expression in rat skeletal muscles. Effects of moderate exercise training and chronic hypoxia. Cell Stress Chaperones 13:483-495
37. Taylor R, Harris M, Starnes J (1999) Acute exercise can improve cardiprotection without increasing heat shock protein content. Am J Physiol 276:H1098-H1102 (Pubitemid 29157486)
38. Taylor RP, Ciccolo JT, Starnes JW (2003) Effect of exercise training on the ability of the rat heart to tolerate hydrogen peroxide. Cardiovasc Res 58:575-581 (Pubitemid 36694443)
39. Testa U, Pannitteri G, Condorelli GL (2008) Vascular endothelial growth factors in cardiovascular medicine. J Cardiovasc Med (Hagerstown) 9:1190-1221
40. Yamashita N, Hoshida S, Otsu K, Asahi M, Kuzuya T, Hori M (1999) Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 189:1699-1706 (Pubitemid 29272686)
41. Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, Yu QJ, Guo WY, Wang HC, Gao F (2007) Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis 12:1579-1588 (Pubitemid 47106890)