Gender and age differences in normal adult human brain: Voxel-based morphometric study

Human Brain Mapping

Volumn 32, Issue 7, 2011, Pages 1050-1058

  Takahashi, Ryuichi ^a   Ishii, Kazunari ^b,c   Kakigi, Tatsuya ^d   Yokoyama, Kazumasa ^a  

^a Hyogo Prefectural Rehabilitation Hospital at Nishi Harima   (Japan)

^b Hyogo Brain and Heart Center ^*  (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Hyogo Rehabilitation Center Hospital   (Japan)

Author keywords

Aging; Gender difference; Magnetic resonance imaging; Normal brain; Sex difference; VBM

Indexed keywords

ADULT; AGE; AGED; ANTERIOR CINGULATE; ARTICLE; BRAIN; FEMALE; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; INFERIOR FRONTAL GYRUS; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL CORTEX; PRIORITY JOURNAL; SEX DIFFERENCE; THALAMUS; THREE DIMENSIONAL IMAGING; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BRAIN; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 79958767354     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.21088     Document Type: Article

References (45)

1. Allen JS, Bruss J, Brown C, Damasio H (2005): Methods for studying the aging brain: Volumetric analyses versus VBM. Neurobiol Aging 26: 1275-1278.
2. Allen LS, Hines M, Shryne JE, Gorski RA (1989): Two sexually dimorphic cell groups in the human brain. J Neurosci 9: 497-506.
3. Ankney CD (1992): Differences in brain size. Nature 358: 532.
4. Ashburner J, Friston KJ. (2000): Voxel-based morphometry-The methods. Neuroimage 11(6 Part 1): 805-821.
5. Ashburner J, Hutton C, Frackowiak R, Johnsrude I, Price C, Friston K (1998): Identifying global anatomical differences: Deformation-based morphometry. Hum Brain Mapp 6: 348-357.
6. Boccardi M, Ghidoni R, Govoni S, Testa C, Benussi L, Bonetti M, Binetti G, Frisoni GB (2006): Effects of hormone therapy on brain morphology of healthy postmenopausal women: A voxel-based morphometry study. Menopause 13: 584-591.
7. Boghi A, Rasetti R, Avidano F, Manzone C, Orsi L, D'Agata F, Caroppo P, Bergui M, Rocca P, Pulvirenti L, Bradac GB, Bogetto F, Mutani R, Mortara P. (2006): The effect of gender on planning: An fMRI study using the Tower of London task. Neuroimage 33: 999-1010.
8. Bookstein FL (2001): "Voxel-based morphometry" should not be used with imperfectly registered images. Neuroimage 14: 1454-1462.
9. Brun CC, Lepore N, Luders E, Chou YY, Madsen SK, Toga AW, Thompson PM (2009): Sex differences in brain structure in auditory and cingulate regions. Neuroreport 20: 930-935.
10. Chen X, Sachdev PS, Wen W, Anstey KJ (2007): Sex differences in regional gray matter in healthy individuals aged 44-48 years: A voxel-based morphometric study. Neuroimage 36: 691-699.
11. Cowell PE, Turetsky BI, Gur RC, Grossman RI, Shtasel DL, Gur RE (1994): Sex differences in aging of the human frontal and temporal lobes. J Neurosci 14: 4748-4755.
12. Escalona PR, McDonald WM, Doraiswamy PM, Boyko OB, Husain MM, Figiel GS, Laskowitz D, Ellinwood EH Jr, Krishnan KR (1991): In vivo stereological assessment of human cerebellar volume: Effects of gender and age. AJNR Am J Neuroradiol 12: 927-929.
13. Filipek PA, Richelme C, Kennedy DN, Caviness VS Jr. (1994): The young adult human brain: An MRI-based morphometric analysis. Cereb Cortex 4: 344-360.
14. Giedd JN, Castellanos FX, Rajapakse JC, Vaituzis AC, Rapoport JL (1997): Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry 21: 1185-1201.
15. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS Jr, Faraone SV, Tsuang MT (2001): Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 11: 490-497.
16. Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001a) Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14: 685-700.
17. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. (2001b): A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14(1 Part 1): 21-36.
18. Gorski RA, Gordon JH, Shryne JE, Southam AM (1978): Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 148: 333-346.
19. Gur RC, Turetsky BI, Matsui M, Yan M, Bilker W, Hughett P, Gur RE (1999): Sex differences in brain gray and white matter in healthy young adults: Correlations with cognitive performance. J Neurosci 19: 4065-4072.
20. Harasty J, Double KL, Halliday GM, Kril JJ, McRitchie DA (1997): Language-associated cortical regions are proportionally larger in the female brain. Arch Neurol 54: 171-176.
21. Haznedar MM, Buchsbaum MS, Hazlett EA, LiCalzi EM, Cartwright C, Hollander E (2006): Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. Am J Psychiatry 163: 1252-1263.
22. Kawachi T, Ishii K, Sakamoto S, Matsui M, Mori T, Sasaki M (2002): Gender differences in cerebral glucose metabolism: A PET study. J Neurol Sci 199: 79-83.
23. Kimura D (2002): Sex hormones influence human cognitive pattern. Neuro Endocrinol Lett 23(Suppl 4): 67-77.
24. Lessov-Schlaggar CN, Reed T, Swan GE, Krasnow RE, DeCarli C, Marcus R, Holloway L, Wolf PA, Carmelli D (2005): Association of sex steroid hormones with brain morphology and cognition in healthy elderly men. Neurology 65: 1591-1596.
25. Levin JM, Ross MH, Mendelson JH, Mello NK, Cohen BM, Renshaw PF (1998): Sex differences in blood-oxygenation-level-dependent functional MRI with primary visual stimulation. Am J Psychiatry 155: 434-436.
26. Luders E, Steinmetz H, Jancke L (2002): Brain size and grey matter volume in the healthy human brain. Neuroreport 13: 2371-2374.
27. Luders E, Narr KL, Thompson PM, Rex DE, Jancke L, Steinmetz H, Toga AW (2004): Gender differences in cortical complexity. Nat Neurosci 7: 799-800.
28. Luders E, Narr KL, Thompson PM, Woods RP, Rex DE, Jancke L, Steinmetz H, Toga AW (2005): Mapping cortical gray matter in the young adult brain: Effects of gender. Neuroimage 26: 493-501.
29. Murphy DG, DeCarli C, McIntosh AR, Daly E, Mentis MJ, Pietrini P, Szczepanik J, Schapiro MB, Grady CL, Horwitz B, Rapoport SI. (1996): Sex differences in human brain morphometry and metabolism: An in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry 53: 585-594.
30. Nopoulos P, Flaum M, O'Leary D, Andreasen NC (2000): Sexual dimorphism in the human brain: Evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Res 98: 1-13.
31. Nunez JL, Jurgens HA, Juraska JM (2000): Androgens reduce cell death in the developing rat visual cortex. Brain Res Dev Brain Res 125: 83-88.
32. Nunez JL, Huppenbauer CB, McAbee MD, Juraska JM, DonCarlos LL (2003): Androgen receptor expression in the developing male and female rat visual and prefrontal cortex. J Neurobiol 56: 293-302.
33. Paus T, Otaky N, Caramanos Z, MacDonald D, Zijdenbos A, D'Avirro D, Gutmans D, Holmes C, Tomaiuolo F, Evans AC (1996): In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior-rostral sulci: Hemispheric asymmetries, gender differences and probability maps. J Comp Neurol 376: 664-673.
34. Peters M, Manning JT, Reimers S (2007): The effects of sex, sexual orientation, and digit ratio (2D:4D) on mental rotation performance. Arch Sex Behav 36: 251-260.
35. Raz N, Gunning-Dixon F, Head D, Williamson A, Acker JD (2001): Age and sex differences in the cerebellum and the ventral pons: A prospective MR study of healthy adults. AJNR Am J Neuroradiol 22: 1161-1177.
36. Sato K, Taki Y, Fukuda H, Kawashima R (2003): Neuroanatomical database of normal Japanese brains. Neural Netw 16: 1301-1310.
37. Schlaepfer TE, Harris GJ, Tien AY, Peng L, Lee S, Pearlson GD (1995): Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study. Psychiatry Res 61: 129-135.
38. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. (2006): Age and gender effects on human brain anatomy: A voxel-based morphometric study in healthy elderly. Neurobiol Aging 28: 1075-1087.
39. Swaab DF, Fliers E (1985): A sexually dimorphic nucleus in the human brain. Science 228: 1112-1115.
40. Swaab DF, Chung WC, Kruijver FP, Hofman MA, Ishunina TA (2001): Structural and functional sex differences in the human hypothalamus. Horm Behav 40: 93-98.
41. Tisserand DJ, van Boxtel MP, Pruessner JC, Hofman P, Evans AC, Jolles J (2004): A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb Cortex 14: 966-973.
42. Tsatsanis KD, Rourke BP, Klin A, Volkmar FR, Cicchetti D, Schultz RT (2003): Reduced thalamic volume in high-functioning individuals with autism. Biol Psychiatry 53: 121-129.
43. Waiter GD, Williams JH, Murray AD, Gilchrist A, Perrett DI, Whiten A (2004): A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder. Neuroimage 22: 619-625.
44. Witelson SF, Glezer, II, Kigar DL (1995): Women have greater density of neurons in posterior temporal cortex. J Neurosci 15(5 Part 1): 3418-3428.
45. Xu J, Kobayashi S, Yamaguchi S, Iijima K, Okada K, Yamashita K (2000): Gender effects on age-related changes in brain structure. AJNR Am J Neuroradiol 21: 112-118.