Effects of hormone therapy on brain morphology of healthy postmenopausal women: A Voxel-based morphometry study

Menopause

Volumn 13, Issue 4, 2006, Pages 584-591

  Boccardi, Marina ^a   Ghidoni, Roberta ^a   Govoni, Stefano ^b   Testa, Cristina ^a,c   Benussi, Luisa ^a   Bonetti, Matteo ^d   Binetti, Giuliano ^a   Frisoni, Giovanni B ^a  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

^d Istituto Clinico Citta di Brescia   (Italy)

Author keywords

Age related changes; Brain; Estrogens; Magnetic resonance; Neuroimaging; Voxel based morphometry

Indexed keywords

ADULT; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN; BRAIN CORTEX; CEREBELLUM; CLUSTER ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; FRONTAL CORTEX; GRAY MATTER; HIPPOCAMPUS; HORMONAL THERAPY; HUMAN; MORPHOLOGY; MORPHOMETRICS; NEOCORTEX; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL CORTEX; PARIETAL LOBE; POSTMENOPAUSE; STRUCTURE ANALYSIS; TEMPORAL CORTEX; THREE DIMENSIONAL IMAGING;

AGING; BRAIN; BRAIN MAPPING; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; POSTMENOPAUSE;

EID: 33746255413     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gme.0000196811.88505.10     Document Type: Article

References (41)

1. Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C. Early postmenopausal hormone therapy may prevent cognitive impairment later in life. Menopause 2005;12:584-591.
2. Tang MX, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;17;348:429-432.
3. Zandi PP, Carlson MC, Plassman BL, et al. Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA 2002;288:2123-2129.
4. LeBlanc ES, Janowsky J, Chan BK, Nelson HD. Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 2001;285:1489-1499.
5. Matthews K, Cauley J, Yaffe K, Zmuda JM. Estrogen replacement therapy and cognitive decline in older community women. J Am Geriatr Soc 1999;47:518-523.
6. Shumaker SA, Legault C, Rapp SR, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003;289:2651-2662.
7. Anderer P, Saletu B, Gruber D, et al. Age-related cognitive decline in the menopause: effects of hormone replacement therapy on cognitive event-related potentials. Maturitas 2005;51:254-269.
8. Rasgon NL, Silverman D, Siddarth P, et al. Estrogen use and brain metabolic change in postmenopausal women. Neurobiol Aging 2005;26:229-235.
9. Resnick SM, Maki PM. Effects of hormone replacement therapy on cognitive and brain aging. Ann NY Acad Sci 2001;949:203-214.
10. Schmidt R, Fazekas F, Reinhart B, et al. Estrogen replacement therapy in older women: a neuropsychological and brain MRI study. J Am Geriatr Soc 1996;44:1307-1313.
11. Eberling JL, Wu C, Haan MN, Mungas D, Buonocore M, Jagust WJ. Preliminary evidence that estrogen protects against age-related hippocampal atrophy. Neurobiol Aging 2003;24:725-732.
12. Resnic SM, Maki PM, Golski S, Kraut MA, Zonderman AB. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm Behav 1998;34:171-182.
13. Ghidoni R, Boccardi M, Benussi L, et al. Effects of estrogens on cognition and brain morphology involvement of the cerebellum. Maturitas 2006;54:222-228.
14. Friston KJ, Glaser DE, Henson RN, Kiebel S, Phillips C, Ashburner J. Classical and Bayesian inference in neuroimaging: applications. Neuroimage 2002;16:484-512.
15. Friston KJ, Penny W, Phillips C, Kiebel S, Hinton G, Ashburner J. Classical and Bayesian inference in neuroimaging: theory. Neuroimage 2002;16:465-483.
16. Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 2002;15:1-25.
17. Cutter WJ, Craig M, Norbury R, Robertson DM, Whiteheaad M, Murphy DG. In vivo effects of estrogen on human brain. Ann N Y Acad Sci 2003;1007:79-88.
18. Toran-Allerand CD. Estrogen and the brain: beyond ER-alpha and ER-beta. Exp Gerontol 2004;39:1579-1586.
19. Hu XY, Qin S, Lu YP, Ravid R, Swaab DF, Zhou JN. Decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in Alzheimer patients. Acta Neuropathol 2003;106:213-220.
20. Zhao L, Wu TW, Brinton RD. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Res 2004;1010:22-34.
21. D'Astous M, Morissette M, Di Paolo T. Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER alpha agonist. Neuropharmacology 2004;47:1180-1188.
22. Tanapat P, Hastings NB, Gould E. Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner. J Comp Neurol 2005;481:252-265.
23. Brannvall K, Bogdanovic N, Korhonen L, Lindholm D. 19-Nortestosterone influences neural stem cell proliferation and neurogenesis in the rat brain. Eur J Neurosci 2005;21:871-878.
24. Osterlund MK, Hurd YL. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 2001;64:251-267.
25. Perez SE, Chen EY, Mufson EJ. Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain. Brain Res Dev Brain Res 2003;145:117-139.
26. Stirone C, Duckles SP, Krause DN. Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen. Am J Physiol Endocrinol Metab 2003;284:E184-E192.
27. Jesmin S, Hattori Y, Sakuma I, Liu MY, Mowa CN, Kitabatake A. Estrogen deprivation and replacement modulate cerebral capillary density with vascular expression of angiogenic molecules in middle-aged female rats. J Cereb Blood Flow Metab 2003;23:181-189.
28. Colton CA, Brown CM, Vitek MP. Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging 2005;26:363-372.
29. in t' Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345:1515-1521.
30. Stirone C, Boroujerdi A, Duckles SP, Krause DN. Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol Pharmacol 2005;67:105-113.
31. Schupf N, Pang D, Patel BN, et al. Onset of dementia is associated with age at menopause in women with Down's syndrome. Ann Neurol 2003;54:433-438.
32. Lambert JC, Coyle N, Lendon C. The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease. J Med Genet 2004;41:104-112.
33. Inestrosa NC, Marzolo MP, Bonnefont AB. Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease. Mol Neurobiol 1998;17:73-86.
34. Rhodin JA, Thomas TN, Clark L, Garces A, Bryant M. In vivo cerebrovascular actions of amyloid beta-peptides and the protective effect of conjugated estrogens. J Alzheimers Dis 2003;5:275-286.
35. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, MarkesberyWR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813-817.
36. Craig MC, Maki PM, Murphy DG. The Women's Health Initiative Memory Study: findings and implications for treatment. Lancet Neurol 2005;4:190-194.
37. Rice MM, Graves AB, McCurry SM, et al. Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame Project. Arch Intern Med 2000;160:1641-1649.
38. Espeland MA, Rapp SR, Shumaker SA, et al. Women's Health Initiative Memory Study. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004;291:2959-2968.
39. Pirskanen M, Hiltunen M, Mannermaa A, et al. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women. Eur J Hum Genet 2005;13:1000-1006.
40. Kazama H, Ruberu NN, Murayama S, et al. Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles. Dement Geriatr Cogn Disord 2004;18:145-150.
41. den Heijer T, Schuit SC, Pols HA, et al. Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI. Mol Psychiatry 2004;9:1129-1135.