Somatic mutation of CYLD gene is rare in hematologic and solid malignancies

Leukemia Research

Volumn 35, Issue 7, 2011, Pages

  Kim, Min Sung ^a   Chung, Nak Gyun ^a   Yoo, Nam Jin ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYLD PROTEIN; GENOMIC DNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; BONE MARROW BIOPSY; COLORECTAL CARCINOMA; CYLD GENE; DNA SEQUENCE; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; LETTER; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; SINGLE STRAND CONFORMATION POLYMORPHISM; SOLID TUMOR; SOMATIC MUTATION; STOMACH ADENOCARCINOMA; TUMOR CELL; TUMOR SUPPRESSOR GENE;

DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; HEMATOLOGIC NEOPLASMS; HUMANS; MUTATION; NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TUMOR SUPPRESSOR PROTEINS;

EID: 79958752714     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.02.024     Document Type: Letter

References (6)

1. Perkins N.D., Gilmore T.D. Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ 2006, 13:759-772.
2. Sun S.C., C.Y L.D. A tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ 2010, 17:25-34.
3. Bignell G.R., Warren W., Seal S., Takahashi M., Rapley E., Barfoot R., et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 2000, 25:160-165.
4. Keats J.J., Fonseca R., Chesi M., Schop R., Baker A., Chng W.J., et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007, 12:131-144.
5. Lee J.W., Soung Y.H., Kim S.Y., Lee H.W., Park W.S., Nam S.W., et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005, 24:1477-1480.
6. Hellerbrand C., Bumes E., Bataille F., Dietmaier W., Massoumi R., Bosserhoff A.K. Reduced expression of CYLD in human colon and hepatocellular carcinomas. Carcinogenesis 2007, 28:21-27.