Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: A didactic review

Topics in Magnetic Resonance Imaging

Volumn 21, Issue 2, 2010, Pages 115-128

  Alger, Jeffry R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

brain; concentration; magnetic resonance spectroscopy; metabolite

Indexed keywords

AMPLITUDE MODULATION; HUMAN; MATHEMATICAL ANALYSIS; METABOLITE; NEUROIMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RADIOFREQUENCY; REVIEW;

BRAIN; COMPUTER SIMULATION; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

EID: 79958742493     PISSN: 08993459     EISSN: 15361004     Source Type: Journal    
DOI: 10.1097/RMR.0b013e31821e568f     Document Type: Review

References (81)

1. Bottomley PA. The trouble with spectroscopy papers. Radiology. 1991;181:344-350.
2. Helms G. The principles of quantification applied to in vivo proton MR spectroscopy. Eur J Radiol. 2008;67:218-229.
3. Jansen JF, Backes WH, Nicolay K, et al. 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology. 2006;240:318-332. (Pubitemid 44098628)
4. Knight-Scott J, Haley AP, Rossmiller SR, et al. Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in vivo. Magn Reson Imaging. 2003;21:787-797. (Pubitemid 37259906)
5. Jost G, Harting I, Heiland S. Quantitative single-voxel spectroscopy: the reciprocity principle for receive-only head coils. J Magn Reson Imaging. 2005;21:66-71. (Pubitemid 40041422)
6. Liu S, Fleysher R, Fleysher L, et al. Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med. 2010;63:865-871.
7. Maril N, Lenkinski RE. An automated algorithm for combining multivoxel MRS data acquired with phased-array coils. J Magn Reson Imaging. 2005;21:317-322. (Pubitemid 40280128)
8. Dong Z, Peterson B. The rapid and automatic combination of proton MRSI data using multi-channel coils without water suppression. Magn Reson Imaging. 2007;25:1148-1154. (Pubitemid 47464834)
9. Rodgers CT, Robson MD. Receive array magnetic resonance spectroscopy: whitened singular value decomposition (WSVD) gives optimal Bayesian solution. Magn Reson Med. 2010;63:881-891.
10. Lin JM, Tsai SY, Liu HS, et al. Quantification of nonYwater-suppressed MR spectra with correction for motion-induced signal reduction. Magn Reson Med. 2009;62:1394-1403.
11. Soher BJ, Vermathen P, Schuff N, et al. Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. Magn Reson Imaging. 2000;18:1159-1165. (Pubitemid 32002717)
12. Posse S, Otazo R, Caprihan A, et al. Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 tesla. Magn Reson Med. 2007;58:236-244. (Pubitemid 47267640)
13. Mekle R, Mlynarik V, Gambarota G, et al. MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T. Magn Reson Med. 2009;61:1279-1285.
14. Inglese M, Spindler M, Babb JS, et al. Field, coil, and echo-time influence on sensitivity and reproducibility of brain proton MR spectroscopy. AJNR Am J Neuroradiol. 2006;27:684-688. (Pubitemid 44897798)
15. Chadzynski GL, Klose U. Chemical shift imaging without water suppression at 3 T. Magn Reson Imaging. 2010;28:669-675.
16. Mlynarik V, Gruber S, Moser E. Proton T (1) and T (2) relaxation times of human brain metabolites at 3 tesla. NMR Biomed. 2001;14:325-331. (Pubitemid 32782846)
17. Ethofer T, Mader I, Seeger U, et al. Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 tesla. Magn Reson Med. 2003;50:1296-1301. (Pubitemid 37494031)
18. Kugel H, Roth B, Pillekamp F, et al. Proton spectroscopic metabolite signal relaxation times in preterm infants: a prerequisite for quantitative spectroscopy in infant brain. J Magn Reson Imaging. 2003;17:634-640. (Pubitemid 36665866)
19. Gruber S, Pinker K, Riederer F, et al. Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol. 2008;68:320-327.
20. Kreis R, Slotboom J, Hofmann L, et al. Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects. Magn Reson Med. 2005;54:761-768. (Pubitemid 41457045)
21. Maudsley AA, Darkazanli A, Alger JR, et al. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006;19:492-503. (Pubitemid 43997768)
22. Maudsley AA, Domenig C, Govind V, et al. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med. 2009;61:548-559.
23. Bagory M, Durand-Dubief F, Ibarrola D, et al. "Absolute" quantification in magnetic resonance spectroscopy: validation of a clinical protocol in multiple sclerosis. Conf Proc IEEE Eng Med Biol Soc. 2007:2007;3458-3461.
24. Alger JR, Symko SC, Bizzi A, et al. Absolute quantitation of short TE brain 1H-MR spectra and spectroscopic imaging data. J Comput Assist Tomogr. 1993;17:191-199. (Pubitemid 23086433)
25. Ebel A, Soher BJ, Maudsley AA. Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis. Magn Reson Med. 2001;46:1072-1078. (Pubitemid 33104294)
26. Webb PG, Sailasuta N, Kohler SJ, et al. Automated single-voxel proton MRS: technical development and multisite verification. Magn Reson Med. 1994;31:365-373. (Pubitemid 24108265)
27. Barker PB, Soher BJ, Blackband SJ, et al. Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed. 1993;6:89-94.
28. Geurts JJ, Barkhof F, Castelijns JA, et al. Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility. J Magn Reson Imaging. 2004;20:366-371. (Pubitemid 39121932)
29. Hammen T, Stadlbauer A, Tomandl B, et al. Short TE single-voxel 1H-MR spectroscopy of hippocampal structures in healthy adults at 1.5 teslaVhow reproducible are the results? NMR Biomed. 2005;18: 195-201. (Pubitemid 40716126)
30. Hennig J, Pfister H, Ernst T, et al. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed. 1992;5:193-199.
31. Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med. 1993;30:424-437. (Pubitemid 23300070)
32. Lee PL, Yiannoutsos CT, Ernst T, et al. A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. J Magn Reson Imaging. 2003;17:625-633. (Pubitemid 36665865)
33. Chang L, Lee PL, Yiannoutsos CT, et al. A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age. Neuroimage. 2004;23:1336-1347. (Pubitemid 40260357)
34. Yiannoutsos CT, Ernst T, Chang L, et al. Regional patterns of brain metabolites in AIDS dementia complex. Neuroimage. 2004;23:928-935. (Pubitemid 39451800)
35. Paul RH, Yiannoutsos CT, Miller EN, et al. Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. J Neuropsychiatry Clin Neurosci. 2007;19: 283-292. (Pubitemid 47293901)
36. Traber F, Block W, Freymann N, et al. A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe. Eur Radiol. 2006;16:1096-1103.
37. Chu A, Alger JR, Moore GJ, et al. Proton echo-planar spectroscopic imaging with highly effective outer volume suppression using combined presaturation and spatially selective echo dephasing. Magn Reson Med. 2003;49:817-821. (Pubitemid 36523467)
38. Ebel A, Maudsley AA. Comparison of methods for reduction of lipid contamination for in vivo proton MR spectroscopic imaging of the brain. Magn Reson Med. 2001;46:706-712. (Pubitemid 32906140)
39. Haupt CI, Schuff N, Weiner MW, et al. Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation. Magn Reson Med. 1996;35:678-687. (Pubitemid 26134563)
40. Manganas LN, Zhang X, Li Y, et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science. 2007;318:980-985. (Pubitemid 350098995)
41. Dong Z, Dreher W, Leibfritz D, et al. Challenges of using MR spectroscopy to detect neural progenitor cells in vivo. AJNR Am J Neuroradiol. 2009;30:1096-1101.
42. Cudalbu C, Cavassila S, Rabeson H, et al. Influence of measured and simulated basis sets on metabolite concentration estimates. NMR Biomed. 2008;21:627-636.
43. Soher BJ, Young K, Bernstein A, et al. GAVA: spectral simulation for in vivo MRS applications. J Magn Reson. 2007;185:291-299. (Pubitemid 46635235)
44. Ratiney H, Sdika M, Coenradie Y, et al. Time-domain semi-parametric estimation based on a metabolite basis set. NMR Biomed. 2005;18:1-13. (Pubitemid 40347537)
45. Young K, Govindaraju V, Soher BJ, et al. Automated spectral analysis. I: formation of a priori information by spectral simulation. Magn Reson Med. 1998;40:812-815. (Pubitemid 28543831)
46. Soher BJ, Young K, Govindaraju V, et al. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn Reson Med. 1998;40:822-831. (Pubitemid 28543833)
47. Seeger U, Klose U, Mader I, et al. Parameterized evaluation of macromolecules and lipids in proton MR spectroscopy of brain diseases. Magn Reson Med. 2003;49:19-28. (Pubitemid 36042330)
48. Hofmann L, Slotboom J, Jung B, et al. Quantitative 1H-magnetic resonance spectroscopy of human brain: influence of composition and parameterization of the basis set in linear combination model-fitting. Magn Reson Med. 2002;48:440-453. (Pubitemid 34951321)
49. Seeger U, Mader I, Nagele T, et al. Reliable detection of macromolecules in single-volume 1H NMR spectra of the human brain. Magn Reson Med. 2001;45:948-954.
50. Hiltunen Y, Kaartinen J, Pulkkinen J, et al. Quantification of human brain metabolites from in vivo 1H NMR magnitude spectra using automated artificial neural network analysis. J Magn Reson. 2002;154:1-5.
51. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672-679. (Pubitemid 23360802)
52. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001;14:260-264. (Pubitemid 32611437)
53. Reynolds G, Wilson M, Peet A, et al. An algorithm for the automated quantitation of metabolites in in vitro NMR signalsVtime domain. Magn Reson Med. 2006;56:1211-1219. (Pubitemid 44865302)
54. Laudadio T, Selen Y, Vanhamme L, et al. Subspace-based MRS data quantitation of multiplets using prior knowledge. J Magn Reson. 2004;168:53-65.
55. Vanhamme L, Van Huffel S, Van Hecke P, et al. Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Magn Reson. 1999;140:120-130. (Pubitemid 129609621)
56. Gillies P, Marshall I, Asplund M, et al. Quantification of MRS data in the frequency domain using a wavelet filter, an approximated Voigt lineshape model and prior knowledge. NMR Biomed. 2006;19:617-626.
57. Mierisova S, Ala-Korpela M. MR spectroscopy quantitation: a review of frequency domain methods. NMR Biomed. 2001;14:247-259. (Pubitemid 32611436)
58. Slotboom J, Boesch C, Kreis R. Versatile frequency domain fitting using time domain models and prior knowledge. Magn Reson Med. 1998;39:899-911. (Pubitemid 28237748)
59. Naressi A, Couturier C, Devos JM, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001;12: 141-152. (Pubitemid 32510133)
60. Kanowski M, Kaufmann J, Braun J, et al. Quantitation of simulated short echo time 1H human brain spectra by LCModel and AMARES. Magn Reson Med. 2004;51:904-912. (Pubitemid 38580602)
61. Van Huffel S, Wang Y, Vanhamme L, et al. Automatic frequency alignment and quantitation of single resonances in multiple magnetic resonance spectra via complex principal component analysis. J Magn Reson. 2002;158:1-14.
62. Fayed N, Modrego PJ, Medrano J. Comparative test-retest reliability of metabolite values assessed with magnetic resonance spectroscopy of the brain. The LCModel versus the manufacturer software. Neurol Res. 2009;31:472-477.
63. Zeng W, Liang Z, Wang Z, et al. Decimative subspace-based parameter estimation methods of magnetic resonance spectroscopy based on prior knowledgeVgeneral concept of speed versus accuracy. Magn Reson Imaging. 2008;26:401-412.
64. Laudadio T, Mastronardi N, Vanhamme L, et al. Improved Lanczos algorithms for blackbox MRS data quantitation. J Magn Reson. 2002;157:292-297.
65. Eslami R, Jacob M. Robust reconstruction of MRSI data using a sparse spectral model and high resolution MRI priors. IEEE Trans Med Imaging. 2010;29:1297-1309.
66. Poullet JB, Sima DM, Van Huffel S, et al. Frequency-selective quantitation of short-echo time 1H magnetic resonance spectra. J Magn Reson. 2007;186:293-304. (Pubitemid 46880442)
67. Coron A, Vanhamme L, Antoine JP, et al. The filtering approach to solvent peak suppression in MRS: a critical review. J Magn Reson. 2001;152:26-40.
68. Young K, Soher BJ, Maudsley AA. Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals. Magn Reson Med. 1998;40:816-821. (Pubitemid 28543832)
69. Soher BJ, Maudsley AA. Evaluation of variable line-shape models and prior information in automated 1H spectroscopic imaging analysis. Magn Reson Med. 2004;52:1246-1254. (Pubitemid 39612812)
70. Soreni N, Noseworthy MD, Konyer NB, et al. Interindividual, repositioning, and time-of-day effects on single voxel proton MR spectroscopy of the anterior cingulate cortex. J Magn Reson Imaging. 2010;32:276-282.
71. Maudsley AA, Domenig C, Sheriff S. Reproducibility of serial whole-brain MR spectroscopic imaging. NMR Biomed. 2010; 23:251-256.
72. Mostert JP, Blaauw Y, Koch MW, et al. Reproducibility over a 1-month period of 1H-MR spectroscopic imaging NAA/Cr ratios in clinically stable multiple sclerosis patients. Eur Radiol. 2008;18:1736-1740.
73. Okada T, Sakamoto S, Nakamoto Y, et al. Reproducibility of magnetic resonance spectroscopy in correlation with signal-to-noise ratio. Psychiatry Res. 2007;156:169-174. (Pubitemid 47600628)
74. Wellard RM, Briellmann RS, Jennings C, et al. Physiologic variability of single-voxel proton MR spectroscopic measurements at 3T. AJNR Am J Neuroradiol. 2005;26:585-590. (Pubitemid 43085962)
75. Li BS, Babb JS, Soher BJ, et al. Reproducibility of 3D proton spectroscopy in the human brain. Magn Reson Med. 2002;47:439-446. (Pubitemid 34193997)
76. Langer DL, Rakaric P, Kirilova A, et al. Assessment of metabolite quantitation reproducibility in serial 3D-(1)H-MR spectroscopic imaging of human brain using stereotactic repositioning. Magn Reson Med. 2007;58:666-673. (Pubitemid 47556872)
77. Soreni N, Noseworthy MD, Cormier T, et al. Intraindividual variability of striatal (1)H-MRS brain metabolite measurements at 3 T. Magn Reson Imaging. 2006;24:187-194. (Pubitemid 43175758)
78. Ratai EM, Hancu I, Blezek DJ, et al. Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging. 2008;27: 1188-1193. (Pubitemid 351614635)
79. Hancu I, Blezek DJ, Dumoulin MC. Automatic repositioning of single voxels in longitudinal 1H MRS studies. NMR Biomed. 2005;18:352-361. (Pubitemid 41410355)
80. Macri MA, Garreffa G, Giove F, et al. In vivo quantitative 1H MRS of cerebellum and evaluation of quantitation reproducibility by simulation of different levels of noise and spectral resolution. Magn Reson Imaging. 2004;22:1385-1393. (Pubitemid 40221933)
81. Weber-Fahr W, Ende G, Braus DF, et al. A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia. Neuroimage. 2002;16:49-60. (Pubitemid 34852472)