Changes in myocardial lactate, pyruvate and lactate-pyruvate ratio during cardiopulmonary bypass for elective adult cardiac surgery: Early indicator of morbidity

Journal of Anaesthesiology Clinical Pharmacology

Volumn 27, Issue 2, 2011, Pages 225-232

  Kapoor, P M ^a   Mandal, B ^a   Chowdhury, U K ^a   Singh, S P ^a   Kiran, U ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Coronary sinus; Lactate; Lactate pyruvate ratio; Pyruvate

Indexed keywords

ADRENALIN; DOBUTAMINE; DOPAMINE; FENTANYL; GLYCERYL TRINITRATE; INOTROPIC AGENT; ISOFLURANE; LACTIC ACID; MIDAZOLAM; MORPHINE; OXYGEN; PROMETHAZINE; PYRUVIC ACID; THIOPENTAL; TROPONIN I; VECURONIUM;

ADULT; AORTA CLAMPING; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE REMOVAL; DIAGNOSTIC TEST ACCURACY STUDY; ELECTIVE SURGERY; FEMALE; HEART SURGERY; HUMAN; INTENSIVE CARE UNIT; LACTATE BLOOD LEVEL; LENGTH OF STAY; MALE; MYOCARDIAL DISEASE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

EID: 79958742115     PISSN: 09709185     EISSN: None     Source Type: Journal    
DOI: 10.4103/0970-9185.81819     Document Type: Article

References (22)

1. Baker S, Cadogan M. Varying clinical significance of hyperlactatemia. Critical Care Resusc 2005;7:57-59.
2. Raper RF, Cameron G, Walker D, Bowey JC. Type B lactic acidosis following cardiopulmonary bypass. Crit Care Med 1997;25:46-51.
3. Levy B, Sadoune LO, Gelot AM, Bollaert P, Nabet PG, Larcan A. Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med 2000;28:114-119.
4. Shinde S, Golam K, Patil N, Kumar P, Kesevan. Perioperative blood lactate levels, pyruvate levels and lactate/pyruvate ratio in children undergoing cardiopulmonary bypass for congenital heart disease. Internet J Anaesthesiol 2006;10:1-6.
5. Bäckström T, Franco-Cereceda A. Intravasal microdialysis is superior to intramyocardial microdialysis in detecting local ischaemia in experimental porcine myocardial infarction. Acta Physiol Scand 2004;180:5-12.
6. Heringlake M, Bahlmann L, Misfeld M, Poeling J, Leptien A, Kraatz E, et al. High myocardial lactate concentration is associated poor myocardial function prior to cardiopulmonary bypass. Minerva Anestesiol 2005;71:775-783.
7. Mayer J, Boldt J, Wolf WM, Lang J, Suttner S. Cardiac output derived arterial pressure waveform analysis in patients undergoing cardiac surgery: Validity of a second generation device. Anesth Analg 2008;106:867-872.
8. Gundry SR, Sequiera A, Razzouk AM, McLaughlin JS, Bailey LL. Facile retrograde cardioplegia: transatrial cannulation of the coronary sinus. Ann Thorac Surg 1990;50:882-887.
9. Onorati F, Cristodoro L, Caroleo S, Esposito A, Amantea B, Santangelo E, et al. Troponin I and lactate from coronary sinus predict cardiac complication after myocardial revascularisation. Ann Thorac Surg 2007;83:1016-1023.
10. Crittenden MD. Intraoperative metabolic monitoring of the heart: Clinical assessment of coronary sinus metabolites. Ann Thorac Surg 2001;72:S2220-S2226.
11. Siouffi SY, Kwanik EM, Khuri SF. Methods for the metabolic quantification of regional myocardial ischemia. J Surg Res 1987;43:360-378.
12. Inoue S, Kuro M, Furuya H. What factors are associated with hyperlactatemia after cardiac surgery characterized by wellmaintained oxygen delivery and a normal postoperative course? A retrospective study. Eur J Anaesthesiol 2001;18:576-584.
13. Shinde SB, Golam KK, Kumar P, Patil ND. Blood lactate levels during cardiopulmonary bypass for valvular heart surgery. Ann Card Anaesth 2005;8:38-44.
14. Duke T, Butt W, South M, Karl TR. Early markers of major adverse events in children after cardiac operation. J Thorac Cardiovasc Surg 1997;114:1042-1052.
15. Andersen LW, Landow L, Baek L, Jansen E, Baker S. Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor - a concentrations in patients undergoing cardiopulmonary bypass. Crit Care Med 1993;21:210-217.
16. Hatherill M, Sajjanhar T, Tibby SM, Champion MP, Andersopn D, Marsh MJ, et al. Serum lactate as a predictor of mortality after paediatric cardiac surgery. Arch Dis Child 1997;77:235-238.
17. Raman JS, Bellomo R, Hayhoe M, Tsamitros M, Buxton BF. Metabolic changes and myocardial injury during cardioplegia: A pilot study. Ann Thorac Surg 2001;72:1566-1571.
18. Koh TW, Carr-White GS, DeSouza AC, Ferdinand FD, Hooper J, Kemp M, et al. Intraoperative cardiac Troponin T release and lactate metabolism during coronary artery surgery: Comparision of beating heart with conventional coronary artery surgery with cardiopulmonary bypass. Heart 1999;81:495-500.
19. Rao V, Ivanov J, Weisel RD, Cohen G, Borger MA, Mickle DA. Lactate release during reperfusion predicts low cardiac output syndrome after coronary bypass surgery. Ann Thorac Surg 2001;71:1925-1930.
20. Wikstrom BG, Ronquist G, Waldenstrom A. Dynamics of myocardial metabolism in the preconditioned porcine heart studied using continuous microdialysis. Eur Heart J 1995;16:563-569.
21. Cross HR, Clarke K, Opie LH, Radda GK. Is lactate-induced myocardial ischemia injury mediated by decreased pH or increased intracellular lactate? J Mol Cell Cardiol 1995;27:1369-1381.
22. Metzsch C, Liao Q, Steen S, Algotsson L. Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model. Acta Anaesthesiol Scand 2006;50:99-107.