Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 5, 2011, Pages 517-531

  Zubenko, George S ^a,b   Hughes III, Hugh B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Carnegie Mellon University ^*  (United States)

Author keywords

Animal model; Depression; Genetics; Mouse

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN VENTRICLE; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; FEMALE; FORCED SWIMMING TEST; GENETIC TRANSFECTION; GENETIC VARIABILITY; MAJOR DEPRESSION; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PUP (RODENT); REPRODUCTION;

ANIMALS; BASE SEQUENCE; BRAIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY;

ANIMALIA; MURINAE;

EID: 79958728298     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31197     Document Type: Article

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