Effects of glucose-regulated protein94 (Grp94) on Ig secretion from human blood mononuclear cells

Cell Stress and Chaperones

Volumn 16, Issue 3, 2011, Pages 329-338

  Tramentozzi, Elisa ^a   Zamarchi, Rita ^b   Pagetta, Andrea ^a   Brunati, Anna Maria ^a   Rossi, Elisabetta ^a   Tibaldi, Elena ^a   Finotti, Paola ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

Antibody production; Cell proliferation; Extracellular signal regulated MAP kinases; Heat shock proteins; Lymphocyte activation

Indexed keywords

GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POKEWEED MITOGEN;

ADULT; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOGLOBULIN PRODUCTION; INCUBATION TIME; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VOLUNTEER;

ADULT; ANIMALS; CELL PROLIFERATION; CELL SHAPE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOGLOBULINS; INTRACELLULAR SPACE; LEUKOCYTES, MONONUCLEAR; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RATS; TIME FACTORS;

PHYTOLACCACEAE;

EID: 79958716804     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-010-0245-3     Document Type: Article

References (29)

1. Aligue R, Akhavan-Niak H, Russell P (1994) A role for Hsp90 in cell cycle control: Weel tyrosine kinase activity requires interaction with Hsp90. EMBO J 13:6099-6106
2. Baker-LePain JC, Sarzotti M, Fields TA, Li CY, Nicchitta CV (2002) GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. J Exp Med 196:1447-1459 (Pubitemid 35424939)
3. Baker-LePain JC, Sarzotti M, Nicchitta CV (2004) Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. J Immunol 172:4195-4203 (Pubitemid 38375232)
4. Binder RJ, Anderson KM, Basu S, Srivastava PK (2000) Cutting edge: heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo. J Immunol 165:6029-6035
5. Breloer M, Fleischer B, von Bonin A (1999) In vivo and in vitro activation of T cells after administration of ag-negative heat shock proteins. J Immunol 162:3141-3147 (Pubitemid 29313558)
6. Brunati AM, Contri A, Muenchbach M, James P, Marin O, Pinna LA (2000) GRP94 (endoplasmin) co-purifies with and is phosphor-ylated by golgi apparatus casein kinase. FEBS Lett 471:151-155 (Pubitemid 30190055)
7. Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6:389-395 (Pubitemid 30208155)
8. Ferris DK, Harel-Bellan A, Morimoto RI, Welch WJ, Farrar WL (1988) Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proc Natl Acad Sci USA 85:3850-3854
9. Hauser C, Wilhelm JA, Matter L, Schopfer K (1984) Spontaneous and pokeweed mitogen-induced in vitro IgG production specific for S. aureus cell wall determinants in man. Clin Exp Immunol 57:227-233 (Pubitemid 14083849)
10. Heike M, Weinmann A, Bethke K, Galle PR (1999) Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines. Biochem Pharmacol 58:1381-1387 (Pubitemid 29438639)
11. Indraccolo S, Zamarchi R, Veronese ML, Mazza MR, Mion M, Veronesi A, Panozzo M, Colombatti M, Barelli A, Rocchetto P (1993) Standardization of in vitro synthesis and detection of HIV-1-specific antibodies. J Immunol Methods 157:105-115
12. Li Z, Menoret A, Srivastava P (2002) Roles of heat-shock proteins in antigen presentation and cross-presentation. Curr Opin Immunol 14:45-51 (Pubitemid 34085106)
13. Liang P, MacRae TH (1997) Molecular chaperones and the cytoskeleton. J Cell Sci 110(Pt 13):1431-1440 (Pubitemid 27326662)
14. Liu B, Li Z (2008) Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood 112:1223-1230
15. McLaughlin SH, Smith HW, Jackson SE (2002) Stimulation of the weak ATPase activity of human hsp90 by a client protein. J Mol Biol 315:787-798 (Pubitemid 34729326)
16. Melnick J, Dul JL, Argon Y (1994) Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature 370:373-375
17. More S, Breloer M, Fleischer B, von Bonin A (1999) Activation of cytotoxic T cells in vitro by recombinant gp96 fusion proteins irrespective of the 'fused' antigenic peptide sequence. Immunol Lett 69:275-282 (Pubitemid 29400695)
18. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63 (Pubitemid 14203433)
19. Navaratnam M, Deshpande MS, Hariharan MJ, Zatechka DS Jr, Srikumaran S (2001) Heat shock protein-peptide complexes elicit cytotoxic T-lymphocyte and antibody responses specific for bovine herpesvirus 1. Vaccine 19:1425-1434 (Pubitemid 32332727)
20. Nicchitta CV (2003) Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. Nat Rev Immunol 3:427-432 (Pubitemid 37323202)
21. Reed RC, Berwin B, Baker JP, Nicchitta CV (2003) GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. J Biol Chem 278:31853-31860 (Pubitemid 37048369)
22. Shinozaki F, Minami M, Chiba T, Suzuki M, Yoshimatsu K, Ichikawa Y Terasawa K, Emori Y, Matsumoto K, Kurosaki T, Nakai A, Tanaka K, Minami Y (2006) Depletion of hsp90beta induces multiple defects in B cell receptor signaling. J Biol Chem 281:16361-16369
23. Singh-Jasuja H, Scherer HU, Hilf N, Arnold-Schild D, Rammensee HG, Toes RE, Schild H (2000) The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol 30:2211-2215 (Pubitemid 30655760)
24. Srivastava PK, DeLeo AB, Old LJ (1986) Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci USA 83:3407-3411 (Pubitemid 16043046)
25. Stephanou A, Amin V, Isenberg DA, Akira S, Kishimoto T, Latchman DS (1997) Interleukin 6 activates heat-shock protein 90 beta gene expression. Biochem J 321(Pt 1):103-106 (Pubitemid 27032575)
26. Suto R, Srivastava PK (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269:1585-1588
27. Tamura Y, Peng P, Liu K, Daou M, Srivastava PK (1997) Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 278:117-120 (Pubitemid 27446289)
28. Tramentozzi E, Montopoli M, Orso G, Pagetta A, Caparrotta L, Frasson M, Brunati AM, Finotti P (2008) Stable complexes formed by Grp94 with human IgG promoting angiogenic differentiation of HUVECs by a cytokine-like mechanism. Mol Immunol 45:3639-3648
29. Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H (2002) The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2/4 pathway. J Biol Chem 277:20847-20853 (Pubitemid 34967392)