Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons

International Journal of Clinical and Experimental Pathology

Volumn 4, Issue 2, 2011, Pages 162-168

  Zheng, Jing ^a   Xu, Da Feng ^a   Li, Kui ^a   Wang, Hong Tao ^a   Shen, Peng Cheng ^a   Lin, Min ^a   Cao, Xiao Hua ^b   Wang, Rui ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Dendritic spine density; Fluoxetine; Fluvoxamine; Neuronal development; Ssri

Indexed keywords

FLUOXETINE; FLUVOXAMINE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN; DENDRITE; DRUG EFFECT; EXPLORATORY BEHAVIOR; MALE; MOTOR ACTIVITY; MOUSE; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PYRAMIDAL NERVE CELL; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BRAIN; DENDRITES; EXPLORATORY BEHAVIOR; FLUOXETINE; FLUVOXAMINE; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; PYRAMIDAL CELLS; SEROTONIN UPTAKE INHIBITORS;

EID: 79958716541     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Kessler RC, McGonagle KA, Swartz M, Blazer DG and Nelson CB. Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. J Affect Disord 1993; 29: 85-96.
2. Potter WZ, Rudorfer MV and Manji H. The pharmacologic treatment of depression. N Engl J Med 1991; 325: 633-642.
3. Wisner KL, Gelenberg AJ, Leonard H, Zarin D and Frank E. Pharmacologic treatment of depression during pregnancy. Jama 1999; 282: 1264-1269.
4. Nordeng H, Lindemann R, Perminov KV and Reikvam A. Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors. Acta Paediatr 2001; 90: 288-291.
5. Zeskind PS and Stephens LE. Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior. Pediatrics 2004; 113: 368-375.
6. Chambers CD, Hernandez-Diaz S, Van Marter LJ, Werler MM, Louik C, Jones KL and Mitchell AA. Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 2006; 354: 579-587.
7. Mirmiran M, van de Poll NE, Corner MA, van Oyen HG and Bour HL. Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat. Brain Res 1981; 204: 129-146.
8. Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RC and Paul IA. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 2006; 31: 47-57.
9. Hansen HH, Sanchez C and Meier E. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? J Pharmacol Exp Ther 1997; 283: 1333-1341.
10. Johnston MV and Coyle JT. Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate. J Neurochem 1980; 34: 1429-1441.
11. Vitalis T, Cases O, Callebert J, Launay JM, Price DJ, Seif I and Gaspar P. Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: determination of a sensitive developmental period. J Comp Neurol 1998; 393: 169-184.
12. Ansorge MS, Zhou M, Lira A, Hen R and Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004; 306: 879-881.
13. Engert F and Bonhoeffer T. Dendritic spine changes associated with hippocampal longterm synaptic plasticity. Nature 1999; 399: 66-70.
14. Maletic-Savatic M, Malinow R and Svoboda K. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 1999; 283: 1923-1927.
15. Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH and Bloom FE. Earlyonset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2006; 103: 5161-5166.
16. Purpura DP. Dendritic spine "dysgenesis" and mental retardation. Science 1974; 186: 1126-1128.
17. Calizo LH and Flanagan-Cato LM. Estrogen selectively regulates spine density within the dendritic arbor of rat ventromedial hypothalamic neurons. J Neurosci 2000; 20: 1589-1596.
18. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW and Sanes JR. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000; 28: 41-51.
19. Kasai H, Matsuzaki M, Noguchi J, Yasumatsu N and Nakahara H. Structure-stability-function relationships of dendritic spines. Trends Neurosci 2003; 26: 360-368.