Misunderstandings of the genetics and neurobiology of ADHD: Moving beyond anachronisms

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 5, 2011, Pages 513-516

  Cortese, Samuele ^a   Faraone, Stephen V ^b   Sergeant, Joseph ^c  

^a NEW YORK UNIVERSITY CHILD STUDY CENTER   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5HTT PROTEIN; DRD4 PROTEIN; DRD5 PROTEIN; HTR1B PROTEIN; PROTEIN; SLC6A3 PROTEIN; SNAP25 PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT PREGNANCY; ATTENTION DEFICIT DISORDER; CHILD ABUSE; DIZYGOTIC TWINS; EDITORIAL; ENVIRONMENTAL FACTOR; EPILEPSY; GENETIC ASSOCIATION; HUMAN; MATERNAL SMOKING; MOLECULAR GENETICS; MONOZYGOTIC TWINS; NEUROBIOLOGY; PHENOTYPE; PHENYLKETONURIA; PREMATURITY; PRIORITY JOURNAL; SOCIAL STATUS;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; ENVIRONMENT; GENOME-WIDE ASSOCIATION STUDY; HUMANS; NERVOUS SYSTEM DISEASES; ODDS RATIO; RISK FACTORS; TWIN STUDIES AS TOPIC;

EID: 79958715462     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31207     Document Type: Editorial

References (23)

1. Arns M, de Ridder S, Strehl U, Breteler M, Coenen A. 2009. Efficacy of neurofeedback treatment in ADHD: The effects on inattention, impulsivity and hyperactivity: A meta-analysis. Clin EEG Neurosci 40: 180-189.
2. Bellgrove MA, Hawi Z, Kirley A, Fitzgerald M, Gill M, Robertson IH. 2005a. Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder. Neuropsychopharmacology 30: 2290-2297.
3. Bellgrove MA, Hawi Z, Lowe N, Kirley A, Robertson IH, Gill M. 2005b. DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): Effects of associated alleles at the VNTR and -521 SNP. Am J Med Genet Part B 136B: 81-86.
4. Burt SA. 2009. Rethinking environmental contributions to child and adolescent psychopathology: A meta-analysis of shared environmental influences. Psychol Bull 135: 608-637.
5. Cronk NJ, Slutske WS, Madden PA, Bucholz KK, Reich W, Heath AC. 2002. Emotional and behavioral problems among female twins: An evaluation of the equal environments assumption. J Am Acad Child Adolesc Psychiatry 41: 829-837.
6. Durston S, Belle JV, Zeeuw PD. 2010. Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biol Psychiatry Oct 19. [Epub ahead of print].
7. Faraone SV, Biederman J. 2000. Nature, nurture, and attention-deficit/hyperactivity disorder. Dev Rev 20: 568-581.
8. Franke B, Neale BM, Faraone SV. 2009. Genome-wide association studies in ADHD. Hum Genet 126: 13-50.
9. Gizer IR, Ficks C, Waldman ID. 2009. Candidate gene studies of ADHD: A meta-analytic review. Hum Genet 126: 51-90.
10. Gonon F, Cohen D. 2011. Le trouble déficitaire de l'attention avec hyperactivité. La génétique est-elle impliquée? Med Sci (Paris) 27: 315-317.
11. Gonon F, Bezard E, Boraud T. 2011. Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: The case of attention deficit hyperactivity disorder. PLoS ONE 6: e14618.
12. Hoekzema E, Carmona S, Ramos-Quiroga JA, Barba E, Bielsa A, Tremols V, Rovira M, Soliva JC, Casas M, Bulbena A, Tobena A, Vilarroya O. 2011. Training-induced neuroanatomical plasticity in ADHD: A tensor-based morphometric study. Hum Brain Mapp [Epub ahead of print]. DOI: 10.1002/hbm.21143.
13. Hudziak JJ, Faraone SV. 2010. The new genetics in child psychiatry. J Am Acad Child Adolesc Psychiatry 49: 729-735.
14. Joseph JJ. 2000. Not in their genes: A critical view of the genetics of attention-deficit/hyperactivity disorder. Dev Rev 20: 539-567.
15. Meehl PE. 1977. Specific genetic etiology, psychodynamics, and therapeutic nihilism. In: Meehl PE, editor. Psychodiagnosis: Selected papers. New York: Norton.
16. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV. 2008. Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet Part B 147B: 1337-1344.
17. Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch KP, Faraone SV, Nguyen TT, Schafer H, Holmans P, Daly M, Steinhausen HC, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJ, Langely K, O'Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschewski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49: 884-897.
18. Nigg J, Nikolas M, Burt SA. 2010. Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49: 863-873.
19. Poelmans G, Pauls DL, Buitelaar JK, Franke B. 2011. Integrated genome-wide association study findings: Identification of a neurodevelopmental network for attention deficit hyperactivity disorder. Am J Psychiatry 168: 365-377.
20. Thapar A, Hervas A, McGuffin P. 1995. Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twin study evidence. Behav Genet 25: 537-544.
21. Timimi S, Moncrieff J, Jureidini J, Leo J, Cohen D, Whitfield C, Double D, Bindman J, Andrews H, Asen E, Bracken P, Duncan B, Dunlap M, Albert G, Green M, Greening T, Hill J, Huws R, Karon B, Kean B, McCubbin M, Miatra B, Mosher L, Parry S, DuBose RS, Riccio D, Shulman R, Stolzer J, Thomas P, Vimpani G, Wadsworth A, Walker D, Wetzel N, White R. 2004. A critique of the international consensus statement on ADHD. Clin Child Fam Psychol Rev 7: 59-63.
22. Visscher PM, Hill WG, Wray NR. 2008. Heritability in the genomics era-Concepts and misconceptions. Nat Rev Genet 9: 255-266.
23. Wood AC, Buitelaar J, Rijsdijk F, Asherson P, Kuntsi J. 2010. Rethinking shared environment as a source of variance underlying attention-deficit/hyperactivity disorder symptoms: Comment on Burt (2009). Psychol Bull 136: 331-340.