Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator

Computer Methods in Biomechanics and Biomedical Engineering

Volumn 14, Issue 6, 2011, Pages 549-560

  Xue, Xiangdong ^a   Patel, Mayur K ^a   Kersaudy Kerhoas, Maïwenn ^b   Bailey, Chris ^a   Desmulliez, Marc P Y ^b  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Blood fluid separation; Cross flow filtration; Microchannel device; Microfluidic device; Modelling and simulation

Indexed keywords

CROSS FLOW FILTRATION; FLUID SEPARATION; MICROCHANNEL DEVICE; MICROFLUIDIC DEVICE; MODELLING AND SIMULATIONS;

BIFURCATION (MATHEMATICS); BIOASSAY; BIOCHIPS; BLOOD; DESIGN; DRAG; FLOW FIELDS; FLOW RATE; FLUIDIC DEVICES; FLUIDS; MICROCHANNELS; MICROFLUIDICS; NEWTONIAN FLOW; NON NEWTONIAN FLOW; PRESSURE EFFECTS; SHEAR FLOW; SHEAR STRAIN; STRAIN RATE; VISCOSITY;

MATHEMATICAL MODELS;

ARTICLE; CHEMISTRY; COMPUTER AIDED DESIGN; COMPUTER SIMULATION; EQUIPMENT; EQUIPMENT DESIGN; HUMAN; INSTRUMENTATION; LAB ON A CHIP; MICROFLUIDIC ANALYSIS; PLASMA; PLASMAPHERESIS; THEORETICAL MODEL;

COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; LAB-ON-A-CHIP DEVICES; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, THEORETICAL; PLASMA; PLASMAPHERESIS;

EID: 79958712692     PISSN: 10255842     EISSN: 14768259     Source Type: Journal    
DOI: 10.1080/10255842.2010.485570     Document Type: Article

References (36)

1. Abraham F, Behr M, Heinkenschloss M. 2005. Shape optimization in steady blood flow: a numerical study of non-Newtonian effects. Comput Methods Biomech Biomed Eng. (2):127-137.
2. Aoki R, Yamada M, Yasuda M, Seki M. 2009. In-channel focusing of flowing microparticles utilizing hydrodynamic filtration. Microfluid Nanofluid. 6:571-576.
3. Brown BH, Smallwood RH, Darber DC, Lawford PV, Hose DR. 1999. Medical physics and biomedical engineering. Bristol: Institute of Physics Publishing.
4. Carlson R, Gabel C, Chan S, Austin R. 1997. Self-sorting of white blood cells in a lattice. Phys Rev Lett. 79:2149-2152.
5. Chen R, Tsai SH. 2004. Microfluidic flow switching design using volume of fluid model. Biomed Microdevices. 6(1):81-90.
6. Dandy DS, Dwyer HA. 1990. A sphere in shear flow at finite Reynolds number: effect of shear on particle lift, drag, and heat transfer. J Fluid Mech. 216:381-410.
7. Di Carlo DD, Edd JF, Irlmla D, Tompkins RG, Toner M. 2008. Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem. 80:2204-2211.
8. Dzwinel W, Boryczko K, Yuen DA. 2003. Discrete-particle model of blood dynamics in capillary vessels. J Colloid and Interface Sci. 258:163-173.
9. El-Kareh AW, Secom TW. 2000. A model for red blood cell motion in bifurcating microvessels. Int J Multiphase Flow. 26:1545-1564.
10. Fahraeus R. 1929. The suspension stability of the blood. Physiol Rev. 9:241-274.
11. Fahraeus R, Lindqvist T. 1931. The viscosity of the blood in narrow capillary tubes. Am J Physiol. 96:562-568.
12. Faivre M, Abkarian M, Bickraj K, Stone H. 2006. A geometrical focusing of cells in a microfluidic device: a route to separate blood plasma. BioRheology. 43:147-159.
13. Ferziger JH, Peric M. 1999. Computational methods for fluid dynamics. 2nd rev. ed. London: Springer.
14. Fung YC. 1973. Stochastic flow in capillary blood vessels. Microvasc Res. 5:34-48.
15. Heng CK, Lim TM, Yobas L, Ji HM, Samper V, Chen Y. 2008. Silicon-based microfilters for whole blood cell separation. Biomed Microdevices. 10:251-257.
16. Hester JP, Kellogg RM, Mulzet AP, Kruger VR, McCredie KB, Freireich EJ. 1979. Principles of blood separation and component extraction in a disposable continuous-flow ingle-stage channel. Blood. 54:254-268.
17. Huh D, Bahng JH, Ling Y, Wei H, Kripfgans OD, Fowlkes JB, Grotberg JB, Takayama S. 2007. A gravity-driven microfluidic particle sorting device with hydrodynamic eparation amplification. Anal Chem. 79:1369-1376.
18. Jaggi RD, Sandoz R, Effenhauser CS. 2007. Microfluidic depletion of red blood cells from whole blood in high-aspectratio microchannels. Microfluid Nanofluid. 3:47-53.
19. Kersaudy-Kerhoas M, Dhariwal R, Desmulliez MPY, Jouvet L. 2010. Hydrodynamic blood plasma separation in microfluidic channels. Microfluid Nanofluid. 8:105-114.
20. Kersaudy-Kerhoas M, Kavanagh D, Xue X, Patel MK, Dhariwal R, Bailey C, Desmulliez MPY. 2008. Integrated biomedical device for flood preparation. Proceedings of 2nd Electronic System-Integration Technology Conference (ESTC), pp. 447-452, London, UK.
21. Korin N, Bransky A, Dinnar U. 2007. Theoretical model and experimental study of red blood cell (RBC) deformation in microchannels. J Biomech. 40:2088-2095.
22. Layek GC, Midya C. 2007. Effect of constriction height on flow separation in a two-dimensional channel. Commun Nonlinear Sci Numer Simul. 12:745-759.
23. Leuprecht A, Perktold K. 2001. Computer simulation of non-Newtonian effects on blood flow in large arteries. Comput Methods Biomech Biomed Eng. 4:149-163.
24. Liu WK, Liu Y, Farrell D, Zhang L, Wang XS, Fukui Y, Patankar N, Zhang Y, Bajaj C, Lee J et al., 2006. Immersed finite element method and its applications to biological ystems. Comput Methods Appl Mech Engrg. 195: 1722-1749.
25. Mackerle J. 2005. Finite element modelling and simulations in cardiovascular mechanics and cardiology: a bibliography 1993-2004. Comput Methods Biomech Biomed Eng. 8(2): 9-81.
26. Mohamed H, Turner JN, Caggana M. 2007. Biochip for separating fetal cells from maternal circulation. J Chromatogr A. 1162:187-192.
27. Peskin CS. 1977. Numerical analysis of blood flow in the heart. J Comput Phys. 25:220-252.
28. Prosperetti A, Tryggvason G. 2007. Computational methods for multiphase flow. Cambridge: Cambridge University Press. p. 9-14.
29. Ramadan Q, Samper V, Poenar D, Yu C. 2006. Magnetic-based microfluidic platform for biomolecular separation. Biomed Microdevices. 8:151-158.
30. Saffman PG. 1965. The lift on a small sphere in a slow shear flow. J Fluid Mech. 22:385-400.
31. Sollier E, Rostainga H, Pouteaua P, Fouillet Y, Luc J. 2009. Achard, passive microfluidic devices for plasma extraction from whole human blood. Sens Actuators B: Chem. 141: 17-624.
32. Wilding P, Kricka LJ, Cheng J, Hvichia G, Shoffner MA, Fortina P. 1998. Integrated cell isolation and polymerase chain reaction analysis using silicon microfilter chambers. Anal iochem. 257:95-100.
33. Woodcock JP. 1976. Physical properties of blood and their influence on blood-flow measurement. Rep Prog Phys. 39: 65-127.
34. Yan ZY, Acrivos A, Weinbaum S. 1991. A three-dimensional analysis of plasma skimming at microvascular bifurcations. Microvasc Res. 42:17-38.
35. Yang S, Undar A, Zahn JD. 2006. A microfluidic device for continuous, real time blood plasma separation. Lab Chip. 6: 871-880.
36. Zhang J, Johnson PC, Popel AS. 2009. Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows. Microvasc es. 77:265-272.