Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma

Clinical Immunology

Volumn 140, Issue 1, 2011, Pages 18-25

  Babu, Suresh K ^a   Puddicombe, Sarah M ^a   Arshad, Hasan H ^a   Wilson, Susan J ^a   Ward, John ^a   Gozzard, Neil ^b   Higgs, Gerry ^c   Holgate, Stephen T ^a   Davies, Donna E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c PharmaconEurope   (United Kingdom)

Author keywords

Adhesion molecule; Airway inflammation; Allergen; Asthma; Tumor necrosis factor

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CELL ADHESION MOLECULE; CERTOLIZUMAB PEGOL; DER P ALLERGEN; HOUSE DUST ALLERGEN; STEROID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; LUNG FUNCTION TEST; MALE; MAST CELL; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION;

ADULT; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CELL ADHESION MOLECULES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HOMEOSTASIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 79958710251     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2011.03.005     Document Type: Article

References (40)

1. Feldmann M., Maini R.N. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat. Med. 2003, 9:1245-1250.
2. Thomas P.S. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol. Cell Biol. 2001, 79:132-140.
3. Keatings V.M., O'Connor B.J., Wright L.G., Huston D.P., Corrigan C.J., Barnes P.J. Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum. J. Allergy Clin. Immunol. 1997, 99:693-698.
4. Thomas P.S., Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax 2002, 57:774-778.
5. Thomas P.S., Yates D.H., Barnes P.J. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am. J. Respir. Crit. Care Med. 1995, 152:76-80.
6. Howarth P.H., Babu K.S., Arshad H.S., Lau L.C., Buckley M.G., McConnell W., Beckett P., Ali M.A., Chauhan A., Wilson S.J., Reynolds A., Davies D.E., Holgate S.T. Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma. Thorax 2005.
7. Berry M.A., Hargadon B., Shelley M., Parker D., Shaw D.E., Green R.H., Bradding P., Brightling C.E., Wardlaw A.J., Pavord I.D. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N. Engl. J. Med. 2006, 354:697-708.
8. Juniper E.F., Buist A.S., Cox F.M., Ferrie P.J., King D.R. Validation of a standardized version of the Asthma Quality of Life Questionnaire. Chest 1999, 115:1265-1270.
9. Erin E.M., Leaker B.R., Nicholson G.C., Tan A.J., Green L.M., Neighbour H., Zacharasiewicz A.S., Turner J., Barnathan E.S., Kon O.M., Barnes P.J., Hansel T.T. The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am. J. Respir. Crit. Care Med. 2006, 174:753-762.
10. Morjaria J.B., Chauhan A.J., Babu K.S., Polosa R., Davies D.E., Holgate S.T. The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax 2008, 63:584-591.
11. Wenzel S.E., Barnes P.J., Bleecker E.R., Bousquet J., Busse W., Dahlen S.E., Holgate S.T., Meyers D.A., Rabe K.F., Antczak A., Baker J., Horvath I., Mark Z., Bernstein D., Kerwin E., Schlenker-Herceg R., Lo K.H., Watt R., Barnathan E.S., Chanez P. A randomized, double-blind, placebo-controlled study of TNF-{alpha} blockade in severe persistent asthma. Am. J. Respir. Crit. Care Med. 2009.
12. Investigative use of bronchoscopy, lavage and bronchial biopsies in asthma and other airways diseases. Clin Exp Allergy 1991, 21:533-539.
13. Choy E.H., Hazleman B., Smith M., Moss K., Lisi L., Scott D.G., Patel J., Sopwith M., Isenberg D.A. Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatol. (Oxford) 2002, 41:1133-1137.
14. Winter T.A., Wright J., Ghosh S., Jahnsen J., Innes A., Round P. Intravenous CDP870, a PEGylated Fab' fragment of a humanized antitumour necrosis factor antibody, in patients with moderate-to-severe Crohn's disease: an exploratory study. Aliment. Pharmacol. Ther. 2004, 20:1337-1346.
15. Brightling C., Berry M., Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol. 2008, 121:5-10. quiz 11-12.
16. Jaffar Z., Roberts K., Pandit A., Linsley P., Djukanovic R., Holgate S. B7 costimulation is required for IL-5 and IL-13 secretion by bronchial biopsy tissue of atopic asthmatic subjects in response to allergen stimulation. Am. J. Respir. Cell Mol. Biol. 1999, 20:153-162.
17. Lordan J.L., Davies D.E., Wilson S.J., Dent G., Corkhill A., Jaffar Z., Roberts K., Djukanovi R., Holgate S.T. The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma. The Journal of Allergy and Clinical Immunology 2001, 108:976-981.
18. Cockcroft D.W., Hargreave F.E., O'Byrne P.M., Boulet L.P. Understanding allergic asthma from allergen inhalation tests. Can. Respir. J. 2007, 14:414-418.
19. Gauvreau G.M., Evans M.Y. Allergen inhalation challenge: a human model of asthma exacerbation. Contrib. Microbiol. 2007, 14:21-32.
20. Ihre E., Zetterstrom O. Increase in non-specific bronchial responsiveness after repeated inhalation of low doses of allergen. Clin. Exp. Allergy 1993, 23:298-305.
21. Liu L.Y., Swenson C.A., Kelly E.A., Kita H., Jarjour N.N., Busse W.W. Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation. J. Allergy Clin. Immunol. 2003, 111:818-825.
22. de Blay F., Krieger P., Spirlet F., Moreau L., Duvernelle C., Kassel O., Kopferschmitt M.C., Gasser B., Demangeat C., Pauli G., Frossard N. Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationic protein levels. Int. Arch. Allergy Immunol. 1999, 120:158-165.
23. Roquet A., Lagging E., Ihre E., van Hage-Hamsten M., Hallden G., Harfast B., Zetterstrom O. No signs of activity markers in peripheral blood despite increased bronchial reactivity after repeated low-dose allergen exposure. APMIS 1998, 106:293-299.
24. Bradding P., Roberts J.A., Britten K.M., Montefort S., Djukanovic R., Mueller R., Heusser C.H., Howarth P.H., Holgate S.T. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell Mol. Biol. 1994, 10:471-480.
25. Laitinen L.A., Laitinen A., Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am. Rev. Respir. Dis. 1993, 147:697-704.
26. Lozewicz S., Gomez E., Ferguson H., Davies R.J. Inflammatory cells in the airways in mild asthma. BMJ 1988, 297:1515-1516.
27. Gamble J.R., Harlan J.M., Klebanoff S.J., Vadas M.A. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc. Natl Acad. Sci. U.S.A. 1985, 82:8667-8671.
28. Pober J.S., Gimbrone M.A., Lapierre L.A., Mendrick D.L., Fiers W., Rothlein R., Springer T.A. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 1986, 137:1893-1896.
29. Palmqvist M., Pettersson K., Sjostrand M., Andersson B., Lowhagen O., Lotvall J. Mild experimental exacerbation of asthma induced by individualised low-dose repeated allergen exposure. A double-blind evaluation. Respir. Med. 1998, 92:1223-1230.
30. Jaffar Z.H., Stanciu L., Pandit A., Lordan J., Holgate S.T., Roberts K. Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta T cells. J Immunol 1999, 163:6283-6291.
31. Coward W.R., Okayama Y., Sagara H., Wilson S.J., Holgate S.T., Church M.K. NF-kappaB and TNF-alpha: a positive autocrine loop in human lung mast cells?. J. Immunol. 2002, 169:5287-5293.
32. Van Assche G., Vermeire S., Rutgeerts P. Focus on mechanisms of inflammation in inflammatory bowel disease sites of inhibition: current and future therapies. Gastroenterol. Clin. North Am. 2006, 35:743-756.
33. Van den Brande J.M., Koehler T.C., Zelinkova Z., Bennink R.J., te Velde A.A., ten Cate F.J., van Deventer S.J., Peppelenbosch M.P., Hommes D.W. Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease. Gut 2007, 56:509-517.
34. Amrani Y., Chen H., Panettieri R.A. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?. Respir. Res. 2000, 1:49-53.
35. Begueret H., Berger P., Vernejoux J.M., Dubuisson L., Marthan R., Tunon-de-Lara J.M. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007, 62:8-15.
36. Brightling C.E., Bradding P., Symon F.A., Holgate S.T., Wardlaw A.J., Pavord I.D. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 2002, 346:1699-1705.
37. Gibson P.G., Saltos N., Borgas T. Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma. J. Allergy Clin. Immunol. 2000, 105:752-759.
38. Silvestri M., Bontempelli M., Giacomelli M., Malerba M., Rossi G.A., Di Stefano A., Rossi A., Ricciardolo F.L. High serum levels of tumour necrosis factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation?. Clin. Exp. Allergy 2006, 36:1373-1381.
39. Wenzel S.E. The significance of neutrophils in asthma. Clin. Exp. Allergy Rev. 2001, 1:89-92.
40. Babu K.S., Morjaria J.B., Puddicombe S., Arshad H.S., Chauhan A., Davies D.E., Holgate S. Etanercept treatment of refractory asthma reduces neutrophils along with TNF-α and IL-8 levels in induced sputum. Am. J. Respir. Crit. Care Med. 2006, 3:A214.