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Angewandte Chemie - International Edition

Volumn 50, Issue 25, 2011, Pages 5734-5736

Pan-src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells

(17) Staerk, Judith a Lyssiotis, Costas A b Medeiro, Lea A a Bollong, Michael b Foreman, Ruth K a Zhu, Shoutian b Garcia, Michael c Gao, Qing a Bouchez, Laure C b Lairson, Luke L b Charette, Bradley D b Supekova, Lubica b Janes, Jeffrey c Brinker, Achim c Cho, Charles Y c Jaenisch, Rudolf a Schultz, Peter G b

a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (United States)

b SCRIPPS RESEARCH INSTITUTE (United States)

c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (United States)

Author keywords

cell based screening; dasatinib; iPS cells; Sox2; Src family kinases

Indexed keywords

CELL-BASED SCREENING; DASATINIB; IPS CELLS; SOX2; SRC-FAMILY KINASE;

ENZYMES;

CELLS;

DASATINIB; DOXYCYCLINE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; SOX2 PROTEIN, MOUSE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR SOX; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOUSE; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL;

ANIMALS; DOXYCYCLINE; FIBROBLASTS; HIGH-THROUGHPUT SCREENING ASSAYS; INDUCED PLURIPOTENT STEM CELLS; MICE; NUCLEAR REPROGRAMMING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SOXB1 TRANSCRIPTION FACTORS; SRC-FAMILY KINASES; THIAZOLES; TRANSFORMING GROWTH FACTOR BETA;

EID: 79958293319 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201101042 Document Type: Article

Times cited : (45)

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