Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3339-3347

  Wu, Wei Bin ^a   Ou, Jie Bin ^a   Huang, Zhi Hong ^a   Chen, Shuo Bin ^a   Ou, Tian Miao ^a   Tan, Jia Heng ^a   Li, Ding ^a   Shen, Liu Lan ^b   Huang, Shi Liang ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cytotoxic activity; Mansonone F derivatives; Synthesis; Topoisomerase I; Topoisomerase II

Indexed keywords

2 (1,2 DIHYDRO 3 METHYL 1,2 DIOXY 4 NAPHTHOXY)ACETONITRILE; 3 (4 FLUOROBENZYL) 9 CHLOROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 (4 FLUOROPHENYL) 3 HYDROXYL 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 (4 FLUOROPHENYL) 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 (4 FLUOROPHENYL)BENZO[DE]BENZOPYRAN 7,8 DIONE; 3 ALLYL 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 ALLYL 9 CHLOROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 BENZYL 3 HYDROXYL 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 BENZYL 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 BENZYL 9 CHLOROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 BENZYLBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 METHYL 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 METHYL 3 HYDROXYL 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 METHYL 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 N PROPYL 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 PHENYL 3 HYDROXYL 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 PHENYL 3 HYDROXYL 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 PHENYL 9 CHLOROBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 PHENYLBENZO[DE]BENZOPYRAN 7,8 DIONE; 3 PROPYL 9 CHLOROBENZO[DE]BENZOPYRAN 7,8 DIONE; 4 (2 OXYPROPROXY) 3 METHYL 1,2 NAPHTHOQUINONE; 4 ALLYL 3 METHYL 1,2 NAPHTHOQUINONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; MANSONONE F DERIVATIVE; METHYL 3 BENZOYLOXY 9 CHLORO 2,3 DIHYDROBENZO[DE]BENZOPYRAN 7,8 DIONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; NAPHTHOQUINONES; NASOPHARYNGEAL NEOPLASMS; PLASMIDS; PYRANS; QUINONES; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE; TOPOISOMERASE INHIBITORS;

EID: 79958290924     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.059     Document Type: Article

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