Improvement in endothelial dysfunction in patients with systemic lupus erythematosus with N-acetylcysteine and atorvastatin

Indian Journal of Pharmacology

Volumn 43, Issue 3, 2011, Pages 311-315

  Kudaravalli, Jyothsna ^a  

^a Bhaskar Medical College   (India)

Author keywords

C reactive protein; reflection index; salbutamol; stiffness index

Indexed keywords

ACETYLCYSTEINE; ALTOVAS; ATORVASTATIN; C REACTIVE PROTEIN; MALONALDEHYDE; MUCOMIX; SALBUTAMOL; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; HEMODYNAMIC PARAMETERS; HUMAN; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OXIDATIVE STRESS; REFLECTION INDEX; STIFFNESS INDEX; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 79958268926     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.81511     Document Type: Article

References (32)

1. Ingami T, Naruse M, Hoover R. Endothelium as an endocrine organ. Ann Rev Physiol 1995;57:171-89.
2. Anderson TJ, Gerhard MD, Meridith IT, Charbonneau F, Delegrange D, Creager MA, et al.. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol 1995;75:71-4.
3. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Creager MA. Impaired endothelium-dependant vasodilatation in patients with Insulin-dependent diabetes mellitus. Circulation 1993;88:2510-6. (Pubitemid 23360174)
4. Panja JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium- dependant vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-7. (Pubitemid 20209468)
5. Chauhan A, Mullins PA, Taylor G, Petch MC, Schofi eld PM. Both endotheliumdependant and endothelium-independent function is impaired in patients with angina pectoris and normal coronary angiograms. Eur Heart J 1997;18:60-8. (Pubitemid 27105772)
6. Henning B, Chow CK. Lipid peroxidation and endothelial cell injury: Implications in atherosclerosis. Free Radic Biol Med 1998;4:106-9.
7. Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelial dependant vasodilatation in forearm resistance vessels of humans. Hypertension 1996;27:849-53. (Pubitemid 26113830)
8. Cholon S, Moreno HJ, Benowitz NI, Hoffman BB, Blaschke TF. Nicotine impairs endothelial dependent vasodilatation in forearm resistance vessels of humans. Clin Pharmacol Ther 2000;67:391-7.
9. Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk CB. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveole. Circ Res 1999;85:29-37. (Pubitemid 29321039)
10. Bruce IN, Gladman DD, Urowitz MB. Detection and modifi cation of risk factors for coronary artery disease in patients with SLE. A quality improvement study. Clin Exp Rheumatol 1998:16:435-40. (Pubitemid 28370855)
11. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003;23:168-75. (Pubitemid 36231924)
12. Ceriello A, Quatraro A, Caretta F, Varano R, Guigliano D. Evidence of possible role of oxygen free radicals in the abnormal functional arterial vasomotion in insulin-dependent diabetics. Diabetes Metab 1990;16:318-22.
13. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classifi cation of Systemic Lupus Erythematosus. Arthritis Rheum 1997;40:1725.
14. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of SLEDAI. A disease activity index for lupus patients. The committee on Prognosis Studies in SLE. Arthritis Rheum 1992;35:630-40.
15. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, et al.. Nitric Oxide is responsible for fl ow-mediated dilatation of human peripheral conduit arteries in vivo. Circulation 1995;91:1314-9.
16. Dawes M, Chowienczyk PJ, Ritter JM. Effects of inhibition of the L-argnine/nitric oxide pathway on vasodilatation caused by beta-agonists in human forearm. Circulation 1997;95:2293-7. (Pubitemid 27191007)
17. El-Magadmi M, Bodill H, Ahmad Y, Durrington PN, Mackness M, Walker M, et al.. Systemic Lupus Erythematosus: An independent risk factor for endothelial dysfunction in women. Circulation 2004;110:399-404. (Pubitemid 38993848)
18. Placer ZA, Crushman LL, Johnson BC. Estimation of products of lipid peroxidation (malondialdehyde) in biochemical systems. J Biol Chem 1966;16:359.
19. Koh KK, Schenke WH, Walclawiw MA, Csako G, Cannon RO III. Statin attenuates increase in C-reactive protein during estrogen replacement therapy in postmenopausal women. Circulation 2002;105:1531-3. (Pubitemid 34297625)
20. Heibel RH, O'Toole JD, Curtiss EI, Medsger TA Jr, Reddy SP, Shaver JA. Coronary arteritis in Systemic Lupus Erythematosus. Chest 1976;69:700-3.
21. Scholze A, Rinder C, Beige J, Riezler R, Zidek W, Tepel M. Acetylcysteine Reduces Plasma Homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure. Circulation 2004;109:369-74. (Pubitemid 38133906)
22. Hernández-Perera O, Pérez-Sala D, Navarro-Antolín J, Sánchez-Pascuala R, Hernández G, Díaz C, et al.. Effect of the 3-hydroxy-3methylglutaryl- Coa reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 1998;101:2711-9. (Pubitemid 28294580)
23. Chowienczyk PJ, Kelly RP, MacCallum H, Millasseau SC, Andersson TL, Gosling RG, et al.. Photoplethysmographic assessment of pulse wave refl ection: Blunted response to endothelial dependent beta-2-adrenergic vasodilation in type II diabetes mellitus. J Am Coll Cardiol 1999;34:2007-14. (Pubitemid 30002658)
24. Chan TM, Yu PM, Tsang KL, Cheng IK. Endothelial cell binding by human polyclonal anti-DNA antibodies: Relationship to disease activity and endothelial functional alterations. Clin Exp Immunol 1995:100:506-13.
25. Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002:106:1439-41.
26. Heinloth A, Heermeier K, Raff U, Wanner C, Galle J. Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells. J Am Soc Nephrol 2000;11:1819-25.
27. Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, et al.. Mechanisms of increased vascular superoxide production in humans: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002;105:1656-62. (Pubitemid 34298608)
28. Vasa M, Fichtlscherer S, Adler K, Aicher A, Martin H, Zeiher AM, et al.. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 2001;103:2885-90. (Pubitemid 32578123)
29. Munro R, Morrison E, McDonald AG, Hunter JA, Madhok R, Capell HA. Effect of disease modifying agents on the lipid profi les of patients with rheumatoid arthritis. Ann Rheum Dis 1997:56:374-7. (Pubitemid 27305426)
30. Signorelli SS, Neri S, Di Pino L, Costa MP, Pennisi G, Digrandi D, et al.. Oxidative stress and endothelial damage in patients with asymptomatic carotid atherosclerosis. Clin Exp Med 2001;1:9-12. (Pubitemid 32972404)
31. Halliwell B, Zaho K, Whiteman M. Nitric oxide and peroxyl nitrite. The ugly, the uglier and not the so good: A personal review of recent controversies. Free Radic Res 1999;31:651-69.
32. Tepel M, van der Giet M, Statz M, Jankowski J, Zidek W. The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: A randomized, controlled trial. Circulation 2003;107:992-5. (Pubitemid 36258722)