Effects of inhibition of the L-arginine/nitric oxide pathway on vasodilation caused by β-adrenergic agonists in human forearm

Circulation

Volumn 95, Issue 9, 1997, Pages 2293-2297

  Dawes, Matthew ^a   Chowienczyk, Philip J ^a   Ritter, James M ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

adrenergic, beta; blood flow; endothelium derived factors; receptors; vasodilation

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DOBUTAMINE; ISOPRENALINE; N(G) METHYLARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROSTACYCLIN; SALBUTAMOL; SODIUM CHLORIDE; VERAPAMIL;

ADULT; ARTICLE; BRACHIAL ARTERY; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TACHYPHYLAXIS; VASODILATATION;

EID: 0030888528     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.9.2293     Document Type: Article

References (35)

1. Sutherland EW, Rall TW. Adrenergic Mechanisms, London, UK: Churchill; 1960:295-304.
2. Chowienczyk PJ, Watts GF, Cockcroft JR, Ritter JM. Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia. Lancet. 1992;340:1430-1432.
3. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation. 1993;88:2541-2547.
4. Hashimoto H, Negishi M, Ichikawa A. Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells, Prostaglandins. 1990;40:491-505.
5. Whitney RJ. The measurement of volume changes in human limbs. J Physiol (Lond). 1953;121:l-27.
6. Hokanson DE, Sumner DS, Strandness DE Jr. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng. 1975;22:25-29.
7. Kerslake DM. The effect of the application of an arterial occlusion cuff to the wrist on the blood flow in the human forearm. J Physiol (Lond). 1949;108:451-457.
8. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ. 1990;300:230-235.
9. Graves J, Poston L. β-Adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric Br J Pharmacol. 1993;108:631-637.
10. G-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N-ethylcarboxamidoadenostne or salbutamol in conscious rats. Br J Pharmacol. 1991;103:1725-1732.
11. Gray DW, Marshall I. Novel signal transduction pathway mediating endothelium-dependent β-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol. 1992;107:684-690.
12. Ghaleh B, Bea M-L, Dubois-Rande J-L, Giudicelli J-F, Hittinger L, Bordeaux A. Endothelial modulation of β-adrenergic dilation of large coronary arteries in conscious dogs. Circulation. 1995;92: 2627-2635.
13. Barnes PJ, Brown MJ, Silverman M, Dollery CT. Circulating catecholamines in exercise and hyperventilation induced asthma, Thorax. 1981;36:435-440.
14. Kaye DM, Lefkovits J, Cox H, Lambert G, Jennings G, Turner A, Esler MD. Regional epinephrine kinetics in human heart failure: evidence for extra-adrenal, nonneural release. Am J Physiol. 1995; 269:H182-H188.
15. Karlsberg RP, Cryer PE, Roberts R. Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am Heart J. 1981;102: 24-29.
16. Bravo EL, Tarazi RC, Gifford RW, Stewart BH. Circulating and urinary catecholamincs in phaeochromocytoma: diagnostic and pathophysiological implications, N Engl J Med. 1979;301:682-686.
17. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2: 997-1000.
18. G-monomethyl-L-arginine of vasodilator effects of acetylcholine and methacholine in human forearm vasculature. Br J Pharmacol. 1993;110:736-738.
19. Kanai AJ, Strauss HC, Truskey GA, Crews AL, Grunfield S, Malinski T. Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res. 1995;77:284-293.
20. Koller A, Sun D, Kaley G. Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioies. Am J Physiol. 1994;267:H326-H332.
21. Maurice DH, Hasiam RJ. Nitroprusside enhances isoprenalineinduced increases in cAMP in rat aortic smooth muscle. Eur J Phamacol. 1990;191:471-475.
22. ++-dependent intracellular signalling mechanisms in brain capillary endothelial cells. J Neurochem. 1994;62:2269-2274.
23. Grace GC, Macdonald PS, Dusting GJ. Cyclic nucleotide interactions involved in endothelium-dependent dilation in rat aortic rings. Eur J Pharmacol. 1988;148:17-24.
24. Rebich S, Devine JO, Armstead WM. Role of nitric oxide and cAMP in β-adrenoceptor induced pial artery vasodilation. Am J Physiol. 1995;268:H1071-H1076.
25. Molenaar P, Malta E, Jones CR, Buxton BR, Summers RJ. Autoradiographic localisation and function of β-adrenorecepters on the human internal mammary artery and saphenous vein. Br J Pharmacol. 1988;95:225-233.
26. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373-376.
27. 2+ entry into endothelial cells by activation of potassium channels and membrane hyperpolarization. Biochem J. 1993;291:263-267.
28. Lang CC, Stein CM, Brown RM, Attenuation of isoproterenolmediated vasodilatation in blacks, N Engl J Med. 1995;333:155-160.
29. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27.
30. Cockcroft JR, Chowienczyk PJ, Benjamin N, Ritter JM. Preserved endothelium-dependent vasodilation in patients with essential hypertension. N Engl J Med. 1994;330:1036-1040.
31. Luscher TF. The endothelium and cardiovascular disease: a complex relation. N Engl J Med. 1994;330:1081-1083.
32. Calver A, Collier J, Vallanee P. Inhibition and stimulation of nitric oxide in the human forearm bed of patients with insulin-dependent diabetes. J Clin Invest. 1992;90:2448-2554.
33. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Dcanflcld JE. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 1993;88: 2149-2155.
34. Cockcroft JR, Chowienczyk PJ, Brett SE, Chen CPl-H, Dupont AG, Van Nueten L, Wooding SJ, Ritter JM. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharm Exp Ther. 1995;274:1067-1071.
35. Dhein S, Titzer S, Wallstein M, Muller A, Gerwin R, Panzner B, Klaus W, Celiprolol exerts microvascular dilatation by activation of beta-2-adrenoceptors, Naunvn Schmiedebergs Arch Pharmacol. 1992;346:27-31.