Potential transcriptional regulatory regions exist upstream of the human ezrin gene promoter in esophageal carcinoma cells

Acta Biochimica et Biophysica Sinica

Volumn 43, Issue 6, 2011, Pages 455-464

  Gao, Shuying ^a   Dai, Yanpeng ^a   Yin, Meijun ^a   Ye, Jing ^a   Li, Gang ^b   Yu, Jie ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

enhancer; esophageal carcinoma; ezrin; promoter; VIL2

Indexed keywords

CYTOSKELETON PROTEIN; EZRIN;

ARTICLE; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; PROMOTER REGION; REGULATORY SEQUENCE; TUMOR CELL LINE;

CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; PROMOTER REGIONS, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 79958264713     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmr033     Document Type: Article

References (32)

1. Hiscox S and Jiang WG. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci 1999, 112: 3081-3090. (Pubitemid 29465726)
2. Gautreau A, Poullet P, Louvard D and Arpin M. Ezrin, a plasma membrane- microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 1999, 96: 7300-7305. (Pubitemid 29299656)
3. Crepaldi T, Gautreau A, Comoglio PM, Louvard D and Arpin M. Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol 1997, 138: 423-434. (Pubitemid 27323543)
4. Louvet-Vallee S. ERM proteins: from cellular architecture to cell signaling. Biol Cell 2000, 92: 305-316.
5. Pujuguet P, Del Maestro L, Gautreau A, Louvard D and Arpin M. Ezrin regulates E-cadherin-dependent adherens junction assembly through rac1 activation. Mol Biol Cell 2003, 14: 2181-2191. (Pubitemid 36583562)
6. Hatzoglou A, Ader I, Splingard A, Flanders J, Saade E, Leroy I and Traver S, et al. Gem associates with ezrin and acts via the Rho-GAP Protein Gmip to down-regulate the Rho pathway. Mol Biol Cell 2007, 18: 1242-1252. (Pubitemid 46626619)
7. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M and Gavin M, et al. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 2005, 115: 1785-1796. (Pubitemid 40979717)
8. Chuan YC, Iglesias-Gato D, Fernandez-Perez L, Cedazo-Minguez A, Pang ST, Norstedt G and Pousette A, et al. Ezrin mediates c-Myc actions in prostate cancer cell invasion. Oncogene 2010, 29: 1531-1542.
9. Watanabe K, Tachibana M, Kim S and Watarai M. Participation of ezrin in bacterial uptake by trophoblast giant cells. Reprod Biol Endocrinol 2009, 7: 95.
10. Osawa H, Smith CA, Ra YS, Kongkham PI and Rutka JT. The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells. Neuro Oncology 2009, 11: 381-393.
11. Kang YK, Hong SW, Lee H and Kim WH. Prognostic implications of ezrin expression in human hepatocellular carcinoma. Mol Carcinog 2010, 49: 798-804
12. Deng X, Tannehill-Gregg SH, Nadella MV, He G, Levine A, Cao Y and Rosol TJ. Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases. Clin Exp Metastasis 2007, 24: 107-119. (Pubitemid 46669244)
13. Elliott BE, Meens JA, SenGupta SK, Louvard D and Arpin M. The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 2005, 7: R365-R373.
14. Akisawa N, Nishimori I, Iwamura T, Onishi S and Hollingsworth MA. High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential. Biochem Biophys Res Commun 1999, 258: 395-400. (Pubitemid 29287062)
15. Wang HJ, Zhu JS, Zhang Q, Guo H, Dai YH and Xiong XP. RNAi-mediated silencing of ezrin gene reverses malignant behavior of human gastric cancer cell line SGC-7901. J Dig Dis 2009, 10: 258-264.
16. Wang HJ, Zhu JS, Zhang Q, Sun Q and Guo H. High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy. World J Gastroenterol 2009, 15: 2016-2019.
17. Shen ZY, Xu LY, Chen MH, Li EM, Li JT, Wu XY and Zeng Y. Upregulated expression of ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells. World J Gastroenterol 2003, 9: 1182-1186. (Pubitemid 36805648)
18. Zeng H, Xu L, Xiao D, Zhang H, Wu X, Zheng R and Li Q, et al. Altered expression of ezrin in esophageal squamous cell carcinoma. J Histochem Cytochem 2006, 54: 889-896. (Pubitemid 44106866)
19. Gao SY, Li EM, Cui L, Lu XF, Meng LY, Yuan HM and Xie JJ, et al. Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells. J Biol Chem 2009, 284: 7995-8004.
20. Xie JJ, Xu LY, Xie YM, Zhang HH, Cai WJ, Zhou F and Shen ZY, et al. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer 2009, 124: 2549-2558.
21. Yeh TS, Tseng JH, Liu NJ, Chen TC, Jan YY and Chen MF. Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma. Arch Surg 2005, 140: 1184-1190.
22. Kobel M, Langhammer T, Huttelmaier S, Schmitt WD, Kriese K, Dittmer J and Strauss HG, et al. Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas. Mod Pathol 2006, 19: 581-587.
23. Park HR, Cabrini RL, Araujo ES, Paparella ML, Brandizzi D and Park YK. Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. Tumori 2009, 95: 81-86.
24. Brambilla D and Fais S. The Janus-faced role of ezrin in 'linking' cells to either normal or metastatic phenotype. Int J Cancer 2009, 125: 2239-2245.
25. Kim C, Shin E, Hong S, Chon HJ, Kim HR, Ahn JR and Hong MH, et al. Clinical value of ezrin expression in primary osteosarcoma. Cancer Res Treat 2009, 41: 138-144.
26. Jiang WG and Hiscox S. Cytokine regulation of ezrin expression in the human colon cancer cell line HT29. Anticancer Res 1996, 16: 861-865. (Pubitemid 26182023)
27. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M and Gavin M, et al. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-a-induced transcriptional repression of cyclin A. J Clin Invest 2005, 115: 1785-1796. (Pubitemid 40979717)
28. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A and Yeung C, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004, 10: 182-186. (Pubitemid 38524889)
29. Ogino W, Takeshima Y, Mori T, Yanai T, Hayakawa A, Akisue T and Kurosaka M, et al. High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. J Pediatr Hematol Oncol 2007, 29: 435-439. (Pubitemid 47026243)
30. Sambrook J and Russell D. Molecular Cloning: A Laboratory Manual. 3rd edn. New York: Cold Spring Harbor Laboratory Press, 2000.
31. Zenke M, Grundstrom T and Matthes H. Multiple sequence motifs are involved in SV40 enhancer function. EMBO J 1986, 5: 387-397.
32. Herr W and Clarke J. The SV40 enhancer is composed of multiple functional elements that can compensate for one another. Cell 1986, 45: 461-470.