The effects of HIV-1 infection on endocrine organs

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 25, Issue 3, 2011, Pages 403-413

  Brown, Todd T ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

adrenal; bone; endocrinology; HIV; hypogonadism; inflammation; lipids; thyroid

Indexed keywords

ANTIRETROVIRUS AGENT;

ADRENAL DISEASE; ARTICLE; BONE DISEASE; BONE METABOLISM; DYSLIPIDEMIA; ENDOCRINE DISEASE; EPIDEMIC; GONAD DYSFUNCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PATHOGENESIS; THYROID DISEASE;

EID: 79958261682     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2011.04.005     Document Type: Review

References (102)

1. R. Detels, A. Munoz, and G. McFarlane Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators Journal of the American Medical Association 280 17 1998 Nov 4 1497 1503 (Pubitemid 28507402)
2. F.J. Palella Jr., K.M. Delaney, and A.C. Moorman Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators N.Engl.J.Med 338 13 1998 Mar 26 853 860 (Pubitemid 28135961)
3. Life expectancy of individuals on combination antiretroviral therapy in high-income countries a collaborative analysis of 14 cohort studies Lancet 372 9635 2008 Jul 26 293 299
4. A. Danoff Endocrinologic complications of HIV infection Medical Clinics of North America 80 6 1996 Nov 1453 1469 (Pubitemid 26394048)
5. L. Al-Harthi, J. Voris, and B.K. Patterson Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients HIV Medicine 5 1 2004 Jan 55 65 (Pubitemid 38219983)
6. S.G. Deeks, C.M. Kitchen, and L. Liu Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load Blood 104 4 2004 Aug 15 942 947 (Pubitemid 39038012)
7. J.M. Brenchley, D.A. Price, and T.W. Schacker Microbial translocation is a cause of systemic immune activation in chronic HIV infection Nature Medicine. 12 12 2006 Dec 1365 1371 (Pubitemid 44924494)
8. S.G. Deeks Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy Topics in HIV Medicine 17 4 2009 Sep 118 123
9. R.C. Gallo, P.S. Sarin, and E.P. Gelmann Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS) Science 220 4599 1983 May 865 867 (Pubitemid 13080156)
10. F. Barre-Sinoussi, J.C. Chermann, and F. Rey Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science 220 4599 1983 May 868 871 (Pubitemid 13080157)
11. L.A. Guarda, M.A. Luna, and J.L. Smith Jr. Acquired immune deficiency syndrome: postmortem findings American Journal of Clinical Pathology 81 5 1984 May 549 557 (Pubitemid 14139091)
12. M.L. Tapper, H.Z. Rotterdam, and C.W. Lerner Adrenal necrosis in the acquired immunodeficiency syndrome Annals of Internal Medicine 100 2 1984 Feb 239 241 (Pubitemid 14188780)
13. E.E. Guenthner, S.L. Rabinowe, and N.A. Van Primary Addison's disease in a patient with the acquired immunodeficiency syndrome Annals of Internal Medicine 100 6 1984 Jun 847 848 (Pubitemid 14121599)
14. L.W. Greene, W. Cole, and J.B. Greene Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome Annals of Internal Medicine 101 4 1984 Oct 497 498 (Pubitemid 14018047)
15. S.A. Staras, S.C. Dollard, K.W. Radford, W.D. Flanders, R.F. Pass, and M.J. Cannon Seroprevalence of cytomegalovirus infection in the United States, 1988-1994 Clinical Microbiology & Infectious Diseases 43 9 2006 Nov 1 1143 1151 (Pubitemid 44632796)
16. Y. Hoshino, Y. Nagata, and H. Gatanaga Cytomegalovirus (CMV) retinitis and CMV antigenemia as a clue to impaired adrenocortical function in patients with AIDS Journal of Acquired Immune Deficiency Syndromes 11 14 1997 Nov 15 1719 1724 (Pubitemid 27470273)
17. J.B. Marks Endocrine manifestations of human immunodeficiency virus (HIV) infection American Journal of the Medical Sciences 302 2 1991 Aug 110 117
18. R. Baker, G.A. Rook, and A. Zumla Adrenal function and the hypothalamo-pituitary adrenal axis in immunodeficiency virus-associated tuberculosis International Journal of Tuberculosis and Lung Disease 1 3 1997 Jun 289 290
19. B.J. Glasgow, K.D. Steinsapir, and K. Anders Adrenal pathology in the acquired immune deficiency syndrome American Journal of Clinical Pathology 84 5 1985 Nov 594 597 (Pubitemid 16235297)
20. Y. Arabi, M.R. Fairfax, and M.J. Szuba Adrenal insufficiency, recurrent bacteremia, and disseminated abscesses caused by Nocardia asteroides in a patient with acquired immunodeficiency syndrome Diagnostic Microbiology and Infectious Disease 24 1 1996 Jan 47 51 (Pubitemid 26114857)
21. A.J. Baraia-Etxaburu, A.B. Astigarraga, and O.R. Elorza Primary adrenal failure and AIDS: report of 11 cases and review of the literature Revista Clínica Española 198 2 1998 Feb 74 79
22. P.U. Freda, S.L. Wardlaw, and K. Brudney Primary adrenal insufficiency in patients with the acquired immunodeficiency syndrome: a report of five cases Journal of Clinical Endocrinology and Metabolism 79 6 1994 Dec 1540 1545
23. D.R. Radin, J.A. Esplin, and A.M. Levine AIDS-related non-Hodgkin's lymphoma: abdominal CT findings in 112 patients American Journal of Roentgenology 160 5 1993 May 1133 1139 (Pubitemid 23141268)
24. J.W. Tappero, M.A. Conant, and S.F. Wolfe Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy Journal of the American Academy of Dermatology 28 3 1993 Mar 371 395 (Pubitemid 23075250)
25. A.S. Dobs, M.A. Dempsey, and P.W. Ladenson Endocrine disorders in men infected with human immunodeficiency virus Americen Journal of Medicine 84 3 Pt 2 1988 Mar 611 616
26. M. Abbott, S.H. Khoo, and M.R. Hammer Prevalence of cortisol deficiency in late HIV disease Journal of Infection 31 1 1995 Jul 1 4
27. L. Membreno, I. Irony, and W. Dere Adrenocortical function in acquired immunodeficiency syndrome Journal of Clinical Endocrinology and Metabolism 65 3 1987 Sep 482 487 (Pubitemid 17131436)
28. T. Sano, K. Kovacs, and B.W. Scheithauer Pituitary pathology in acquired immunodeficiency syndrome Archives of Pathology & Laboratory Medicine 113 9 1989 Sep 1066 1070 (Pubitemid 19228105)
29. G. Norbiato, M. Galli, and V. Righini The syndrome of acquired glucocorticoid resistance in HIV infection Baillire's Clinical Endocrinology and Metabolism 8 4 1994 Oct 777 787 (Pubitemid 24314321)
30. J.A. Merenich, M.T. McDermott, and A.A. Asp Evidence of endocrine involvement early in the course of human immunodeficiency virus infection Journal of Clinical Endocrinology and Metabolism 70 3 1990 Mar 566 571
31. J.W. Findling, B.P. Buggy, and I.H. Gilson Longitudinal evaluation of adrenocortical function in patients infected with the human immunodeficiency virus Journal of Clinical Endocrinology and Metabolism 79 4 1994 Oct 1091 1096 (Pubitemid 24342253)
32. S.T. Azar, and J.C. Melby Hypothalamic-pituitary-adrenal function in non-AIDS patients with advanced HIV infection American Journal of the Medical Sciences 305 5 1993 May 321 325 (Pubitemid 23145448)
33. A. Biglino, P. Limone, and B. Forno Altered adrenocorticotropin and cortisol response to corticotropin-releasing hormone in HIV-1 infection European Journal of Endocrinology 133 2 1995 Aug 173 179
34. G. Mastorakos, M.A. Magiakou, and G.P. Chrousos Effects of the immune/inflammatory reaction on the hypothalamic-pituitary-adrenal axis Annals of the New York Academy of Sciences 771 1995 Dec 29 438 448 438-48 (Pubitemid 26077425)
35. G. Norbiato, M. Bevilacqua, and T. Vago Clerici. Glucocorticoids and the immune function in the human immunodeficiency virus infection: a study in hypercortisolemic and cortisol-resistant patients Journal of Clinical Endocrinology and Metabolism 82 10 1997 Oct 3260 3263 (Pubitemid 27419067)
36. M.S. Eledrisi, and A.C. Verghese Adrenal insufficiency in HIV infection: a review and recommendations American Journal of the Medical Sciences 321 2 2001 Feb 137 144 (Pubitemid 32128792)
37. F. Raffi, J.M. Brisseau, and B. Planchon Endocrine function in 98 HIV-infected patients: a prospective study Journal of Acquired Immune Deficiency Syndromes 5 6 1991 Jun 729 733
38. A.S. Dobs, W.L. Few III, and M.R. Blackman Serum hormones in men with human immunodeficiency virus-associated wasting Journal of Clinical Endocrinology and Metabolism 81 11 1996 Nov 4108 4112 (Pubitemid 26380425)
39. T.S. Croxson, W.E. Chapman, and L.K. Miller Changes in the hypothalamic-pituitary-gonadal axis in human immunodeficiency virus-infected homosexual men Journal of Clinical Endocrinology and Metabolism 68 2 1989 Feb 317 321 (Pubitemid 19052870)
40. K.D. Chirgwin, J. Feldman, and O. Muneyyirci-Delale Menstrual function in human immunodeficiency virus-infected women without acquired immunodeficiency syndrome Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 12 5 1996 Aug 15 489 494 (Pubitemid 26274939)
41. A.B. Chabon, R.J. Stenger, and H. Grabstald Histopathology of testis in acquired immune deficiency syndrome Urology 29 6 1987 Jun 658 663 (Pubitemid 17078215)
42. J. Pudney, and D. Anderson Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome American Journal of Pathology 139 1 1991 Jul 149 160
43. G.J. Nuovo, J. Becker, and A. Simsir HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization American Journal of Pathology 144 6 1994 Jun 1142 1148 (Pubitemid 24172075)
44. S. Grinspoon, and K. Mulligan Weight loss and wasting in patients infected with human immunodeficiency virus Journal of Clinical Microbiology & Infectious Diseases 36 Suppl 2 2003 Apr 1 S69 S78
45. T. van der Poll, J.A. Romijn, and E. Endert Effects of tumor necrosis factor on the hypothalamic-pituitary-testicular axis in healthy men Metabolism 42 3 1993 Mar 303 307 (Pubitemid 23073346)
46. R. Roubenoff, S. Grinspoon, and P.R. Skolnik Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men American Journal of Physiology - Endocrinology and Metabolism 283 1 2002 Jul E138 E145
47. A. Pont, J.R. Graybill, and P.C. Craven High-dose ketoconazole therapy and adrenal and testicular function in humans Archives of Internal Medicine 144 11 1984 Nov 2150 2153 (Pubitemid 15215501)
48. J.J. Kopicko, I. Momodu, and A. Adedokun Characteristics of HIV-infected men with low serum testosterone levels International Journal of STD & AIDS 10 12 1999 Dec 817 820
49. G. Wagner, J.G. Rabkin, and R. Rabkin Illness stage, concurrent medications, and other correlates of low testosterone in men with HIV illness Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 8 2 1995 Feb 1 204 207
50. K. Mulligan, R. Zackin, and J.H. Von Roenn Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial Journal of Clinical Endocrinology & Metabolism 92 2 2007 Feb 563 570
51. H.H. Singh, V. Purohit, and B.S. Ahluwalia Methadone blocks dopamine-mediated release of gonadotropins in rat hypothalamus Neuroendocrinology 34 5 1982 347 352 (Pubitemid 12142647)
52. M.L. Adams, B. Sewing, and J.B. Forman Opioid-induced suppression of rat testicular function Journal of Pharmacology and Experimental Therapeutics 266 1 1993 Jul 323 328 (Pubitemid 23315665)
53. F. Brambilla, E. Sacchetti, and M. Brunetta Pituitary-gonadal function in heroin addicts Neuropsychobiology 3 2-3 1977 160 166
54. J.H. Mendelson, R.E. Meyer, and J. Ellingboe Effects of heroin and methadone on plasma cortisol and testosterone Journal of Pharmacology and Experimental Therapeutics 195 2 1975 Nov 296 302
55. J.H. Mendelson, J. Ellingboe, and J.C. Kuehnle Heroin and naltrexone effects on pituitary-gonadal hormones in man: interaction of steroid feedback effects, tolerance and supersensitivity Journal of Pharmacology and Experimental Therapeutics 214 3 1980 Sep 503 506 (Pubitemid 10061392)
56. M.F. Celani, C. Carani, and V. Montanini Further studies on the effects of heroin addiction on the hypothalamic-pituitary-gonadal function in man Pharmacological Research Communications 16 12 1984 Dec 1193 1203 (Pubitemid 15087682)
57. C. Wang, V. Chan, and R.T. Yeung The effect of heroin addiction on pituitary-testicular function Clinical Endocrinology - Oxford (Oxford) 9 5 1978 Nov 455 461 (Pubitemid 9068761)
58. A. Rhodin, M. Stridsberg, and T. Gordh Opioid endocrinopathy: a clinical problem in patients with chronic pain and long-term oral opioid treatment Clinical Journal of Pain 26 5 2010 Jun 374 380
59. L. Calza, R. Manfredi, and F. Chiodo Subclinical hypothyroidism in HIV-infected patients receiving highly active antiretroviral therapy Journal of Acquired Immune Deficiency Syndromes 31 1 2002 361 363 (Pubitemid 35278639)
60. A. Olivieri, M. Sorcini, and P. Battisti Thyroid hypofunction related with the progression of human immunodeficiency virus infection Journal of Endocrinological Investigation 16 1993 407 413 (Pubitemid 23288395)
61. C. Grunfeld, M. Pang, and W. Doerrier Indices of thyroid function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome Metabolism 42 10 1993 1270 1276 (Pubitemid 23304800)
62. J.S. LoPresti, J.C. Fried, and C.A. Spencer Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS) Annals of Internal Medicine 110 12 1989 Jun 15 970 975 (Pubitemid 19156698)
63. E.N. Pearce Diagnosis and management of thyrotoxicosis British Medical Journal 332 2006 1369 1373 (Pubitemid 44365354)
64. D.E. Sellmeyer, and C. Grunfeld Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome Endocrine Reviews 17 5 2006 518 532
65. R. Ranieri, A. Veronelli, and C. Santambrogio Subclinical hypothyroidism in a patient affected by advanced AIDS and visceral leishmaniasis Scandinavian Journal of Infectious Diseases 37 2005 935 937 (Pubitemid 43078111)
66. A.E. Heufelder, and L.C. Hofbauer Human immunodeficiency virus infection and the thyroid gland European Journal of Clinical Endocrinology 134 1996 669 674 (Pubitemid 26226553)
67. E.N. Pearce, A.P. Farwell, and L.E. Braverman Thyroiditis New England Journal of Medicine 348 2003 2646 2655 (Pubitemid 36741593)
68. M.A. Lima, L.L.L. Freitas, and C. Montandon The thyroid in acquired immunodeficiency syndrome Endocrine Pathology 9 1998 217 223 (Pubitemid 28536797)
69. C. Grunfeld, D.P. Kotler, R. Hamadeh, A. Tierney, J. Wang, and R.N. Pierson Hypertriglyceridemia in the acquired immunodeficiency syndrome American Journal of Medicine 86 1 1989 Jan 27 31
70. W. Khovidhunkit, R.A. Memon, and K.R. Feingold Infection and inflammation-induced proatherogenic changes of lipoproteins Journal of Infectious Diseases 181 Suppl. 3 2000 Jun S462 S472 S462-S472
71. C. Grunfeld, M. Pang, W. Doerrler, J.K. Shigenaga, P. Jensen, and K.R. Feingold Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome Journal of Clinical Endocrinology and Metabolism 74 5 1992 May 1045 1052
72. K.R. Feingold, R.M. Krauss, and M. Pang The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B Journal of Clinical Endocrinology and Metabolism 76 6 1993 Jun 1423 1427 (Pubitemid 23164355)
73. P.Y. Hsue, P.W. Hunt, and A. Schnell Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis Journal of Acquired Immune Deficiency Syndromes 23 9 2009 Jun 1 1059 1067
74. G.S. Hotamisligil, P. Peraldi, and A. Budavari IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 5249 1996 Feb 2 665 668 (Pubitemid 26052915)
75. G.S. Hotamisligil, P. Arner, and J.F. Caro Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance Journal of Clinical Investigation 95 5 1995 May 2409 2415
76. M.J. Hommes, J.A. Romijn, and E. Endert Insulin sensitivity and insulin clearance in human immunodeficiency virus-infected men Metabolism 40 6 1991 Jun 651 656
77. T.T. Brown, X. Li, and S.R. Cole Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study Journal of Acquired Immune Deficiency Syndromes 19 13 2005 Sep 2 1375 1383 (Pubitemid 41800673)
78. W.M. El-Sadr, C.M. Mullin, and A. Carr Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral-naive cohort HIV Medicine 6 2 2005 Mar 114 121 (Pubitemid 40425975)
79. J.M. Fakruddin, and J. Laurence HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk Journal of Biological Chemistry 278 48 2003 Nov 28 48251 48258 (Pubitemid 37523280)
80. J.M. Fakruddin, and J. Laurence HIV-1 Vpr enhances production of receptor of activated NF-kappaB ligand (RANKL) via potentiation of glucocorticoid receptor activity Archives of Virology 150 1 2005 Jan 67 78 (Pubitemid 40171950)
81. T. Vikulina, X. Fan, and M. Yamaguchi Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats Proceedings of the National Academy of Sciences of the U.S.A 107 31 2010 Aug 3 13848 13853
82. P. Aukrust, C.J. Haug, and T. Ueland Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone-remodeling process during highly active antiretroviral therapy Journal of Clinical Endocrinology and Metabolism 84 1 1999 Jan 145 150 (Pubitemid 29036693)
83. E. De Crignis, L. Cimatti, and M. Borderi Bone alterations during HIV infection New Microbiology 31 2 2008 Apr 155 164 (Pubitemid 351938110)
84. E. Zapanti, K. Terzidis, and G. Chrousos Dysfunction of the hypothalamic-pituitary-adrenal axis in HIV infection and disease Hormones (Athens.) 7 3 2008 Jul 205 216
85. J.C. Yombi, D. Maiter, and L. Belkhir Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir Clinical Rheumatology 27 Suppl. 2 2008 Dec S79 S82 Epub 2008 Oct 1.:S79-S82
86. K. Dort, S. Padia, and B. Wispelwey Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report AIDS Research and Therapy 6 2009 Jun 8 10
87. Journal of Pediatrics 148 2006
88. K. Samaras, S. Pett, and A. Gowers Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in HIV-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six cases Journal of Clinical Endocrinology and Metabolism 2005 Mar 8
89. E. Sobngwi, V. Lubin, and P. Ury Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose Annales d Endocrinologie (Paris) 64 3 2003 Jun 202 204 (Pubitemid 36876639)
90. M.P. Dube, R.A. Parker, and K. Mulligan Effects of potent antiretroviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a substudy of AIDS Clinical Trials Group Study 384 Clinical Infectious Diseases 45 1 2007 Jul 1 120 126 (Pubitemid 46984627)
91. P. Rietschel, C. Corcoran, and T. Stanley Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy Clinical Infectious Diseases 31 5 2000 Nov 1240 1244 (Pubitemid 32295456)
92. G. Madeddu, A. Spanu, and F. Chessa Thyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy Clinical Endocrinology 64 2006 375 383
93. S. Beltran, F.-X. Lescure, and R. Desailloud THYVI Group. Increased prevalence of hypothyroidism among human immunodeficiency virus-infected patients: a need for screening Clinical Infectious Diseases 37 2003 579 583 (Pubitemid 37011783)
94. J. Collazos, S. Ibarra, and J. Mayo Thyroid hormones in HIV-infected patients in the highly active antiretroviral therapy era Journal of Acquired Immune Deficiency Syndromes 17 1 2003 763 765
95. M. Grappin, L. Piroth, and B. Verges Increased prevalence of subclinical hypothyroidism in HIV patients treated with highly active antiretroviral therapy Journal of Acquired Immune Deficiency Syndromes 14 8 2000 1070 1072 (Pubitemid 30336075)
96. J.G. Hollowell, N.W. Staehling, and W.D. Flanders T4, and thyroid antibodies in the United States Population (1988 to 1994) J.Clin.Endocrinol. Metab 87 2002 489 499
97. D.S. Cooper Subclinical hypothyroidism New England Journal of Medicine 345 2001 260 265 (Pubitemid 32695067)
98. T.T. Brown, S.R. Cole, and X. Li Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study Archives of Internal Medicine 165 10 2005 May 23 1179 1184 (Pubitemid 40720744)
99. T.T. Brown, K. Tassiopoulos, and R.J. Bosch Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy Diabetes Care 33 10 2010 Oct 2244 2249
100. T.T. Brown, and R.B. Qaqish Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review Acquired Immune Deficiency Syndromes 20 17 2006 Nov 14 2165 2174 (Pubitemid 44684707)
101. V.A. Triant, T.T. Brown, and H. Lee Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system Journal of Clinical Endocrinology and Metabolism 93 9 2008 Sep 3499 3504
102. T.T. Brown, G.A. McComsey, and M.S. King Loss of bone mineral density after antiretroviral therapy initiation, independent of antiretroviral regimen Journal of Acquired Immune Deficiency Syndromes 51 5 2009 Aug 554 561