Culture and use of mesenchymal stromal cells in phase i and II clinical trials

Stem Cells International

Volumn , Issue , 2010, Pages

  Philippe, Bourin ^a   Luc, Sensebé ^b   Valérie, Planat Bénard ^c   Jérôme, Roncalli ^d   Alessandra, Bura Rivière ^d   Louis, Casteilla ^c  

^a ETABLISSEMENT FRANÇAIS DU SANG   (France)

^b Service Recherche   (France)

^c Institut National de la Sant é et de la Recherche Medicale   (France)

^d CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; PLACEBO;

ACUTE GRAFT VERSUS HOST DISEASE; ADIPOSE DERIVED STEM CELL; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CELL ADHESION; CELL FUNCTION; CELL STRUCTURE; CULTURE MEDIUM; CULTURE TECHNIQUE; EPITHELIAL MESENCHYMAL TRANSITION; GOOD MANUFACTURING PRACTICE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIMB ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; STROMA CELL; TISSUE ENGINEERING;

EID: 79958244496     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2010/503593     Document Type: Review

References (67)

1. Owen M., Friedenstein A. J., Stromal stem cells: marrow-derived osteogenic precursors Ciba Foundation Symposium 1988 136 42 60
2. Caplan A. I., Mesenchymal stem cells Journal of Orthopaedic Research 1991 9 5 641 650
3. Horwitz E. M., Le Blanc K., Dominici M., Mueller I., Slaper-Cortenbach I., Marini F. C., Deans R. J., Krause D. S., Keating A., Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement Cytotherapy 2005 7 5 393 395 (Pubitemid 41671625)
4. Sensebé L., Krampera M., Schrezenmeier H., Bourin P., Giordano R., Mesenchymal stem cells for clinical application Vox Sang 2010 98 93 107
5. Caplan A. I., Dennis J. E., Mesenchymal stem cells as trophic mediators Journal of Cellular Biochemistry 2006 98 5 1076 1084 (Pubitemid 44128350)
6. Lazarus H. M., Haynesworth S. E., Gerson S. L., Rosenthal N. S., Caplan A. I., Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use Bone Marrow Transplantation 1995 16 4 557 564
7. Horwitz E. M., Gordon P. L., Koo W. K. K., Marx J. C., Neel M. D., McNall R. Y., Muul L., Hofmann T., Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone Proceedings of the National Academy of Sciences of the United States of America 2002 99 13 8932 8937 (Pubitemid 34693661)
8. Ko O. N., Day J., Nieder M., Gerson S. L., Lazarus H. M., Krivit W., Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) Bone Marrow Transplantation 2002 30 4 215 222 (Pubitemid 35023593)
9. Chen S.-L., Fang W.-W., Ye F., Liu Y.-H., Qian J., Shan S.-J., Zhang J.-J., Chunhua R. Z., Liao L.-M., Lin S., Sun J.-P., Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction American Journal of Cardiology 2004 94 1 92 95 (Pubitemid 38813459)
10. Le Blanc K., Frassoni F., Ball L., Locatelli F., Roelofs H., Lewis I., Lanino E., Sundberg B., Bernardo M. E., Remberger M., Dini G., Egeler R. M., Bacigalupo A., Fibbe W., Ringdén O., Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study The Lancet 2008 371 9624 1579 1586 (Pubitemid 351626841)
11. Quarto R., Mastrogiacomo M., Cancedda R., Kutepov S. M., Mukhachev V., Lavroukov A., Kon E., Marcacci M., Repair of large bone defects with the use of autologous bone marrow stromal cells New England Journal of Medicine 2001 344 5 385 386 (Pubitemid 32107654)
12. Vacanti C. A., Bonassar L. J., Vacanti M. P., Shufflebarger J., Replacement of an avulsed phalanx with tissue-engineered bone New England Journal of Medicine 2001 344 20 1511 1514. Erratum in: New England Journal of Medicine. vol. 345, no. 9, p. 704, 2001 (Pubitemid 32429210)
13. Crisan M., Yap S., Casteilla L., Chen C.-W., Corselli M., Park T. S., Andriolo G., Sun B., Zheng B., Zhang L., Norotte C., Teng P.-N., Traas J., Schugar R., Deasy B. M., Badylak S., Buhring H.-J., Giacobino J.-P., Lazzari L., Huard J., Péault B., A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 2008 3 3 301 313
14. da Silva Meirelles L., Chagastelles P. C., Nardi N. B., Mesenchymal stem cells reside in virtually all post-natal organs and tissues Journal of Cell Science 2006 119 11 2204 2213 (Pubitemid 43960310)
15. Zuk P. A., Zhu M., Mizuno H., Huang J., Futrell J. W., Katz A. J., Benhaim P., Lorenz H. P., Hedrick M. H., Multilineage cells from human adipose tissue: implications for cell-based therapies Tissue Engineering 2001 7 2 211 228 (Pubitemid 32295155)
16. Nol D., Caton D., Roche S., Bony C., Lehmann S., Casteilla L., Jorgensen C., Cousin B., Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials Experimental Cell Research 2008 314 7 1575 1584
17. Planat-Benard V., Silvestre J.-S., Cousin B., André M., Nibbelink M., Tamarat R., Clergue M., Manneville C., Saillan-Barreau C., Duriez M., Tedgui A., Levy B., Pénicaud L., Casteilla L., Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives Circulation 2004 109 5 656 663 (Pubitemid 38198874)
18. Garca-Olmo D., Garca-Arranz M., Herreros D., Pascual I., Peiro C., Rodrguez-Montes J. A., A phase I clinical trial of the treatment of crohn's fistula by adipose mesenchymal stem cell transplantation Diseases of the Colon and Rectum 2005 48 7 1416 1423 (Pubitemid 40933870)
19. Garcia-Olmo D., Herreros D., Pascual I., Pascual J. A., Del-Valle E., Zorrilla J., De-La-Quintana P., Garcia-Arranz M., Pascual M., Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase ii clinical trial Diseases of the Colon and Rectum 2009 52 1 79 86
20. Spees J. L., Gregory C. A., Singh H., Tucker H. A., Peister A., Lynch P. J., Hsu S.-H., Smith J., Prockop D. J., Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy Molecular Therapy 2004 9 5 747 756 (Pubitemid 38660428)
21. Yamaguchi M., Hirayama F., Wakamoto S., Fujihara M., Murahashi H., Sato N., Ikebuchi K., Sawada K., Koike T., Kuwabara M., Azuma H., Ikeda H., Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cells expansion Transfusion 2002 42 7 921 927
22. Schwartz K. A., Lu G., Trosko J. E., Chang C. C., Serum from outdated human platelet concentrates: an alternative supplement for tissue (fibroblast) culture media American Journal of Hematology 1984 17 1 23 27 (Pubitemid 14081097)
23. Kocaoemer A., Kern S., Klter H., Bieback K., Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue Stem Cells 2007 25 5 1270 1278 (Pubitemid 46684887)
24. Lucarelli E., Beccheroni A., Donati D., Sangiorgi L., Cenacchi A., Del Vento A. M., Meotti C., Bertoja A. Z., Giardino R., Fornasari P. M., Mercuri M., Picci P., Platelet-derived growth factors enhance proliferation of human stromal stem cells Biomaterials 2003 24 18 3095 3100 (Pubitemid 36944940)
25. Bieback K., Hecker A., Kocamer A., Lannert H., Schallmoser K., Strunk D., Klter H., Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow Stem Cells 2009 27 9 2331 2341
26. Lennon D. P., Haynesworth S. E., Young R. G., Dennis J. E., Caplan A. I., A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells Experimental Cell Research 1995 219 1 211 222
27. Gronthos S., Simmons P. J., The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro Blood 1995 85 4 929 940
28. Rubio D., Garcia-Castro J., Martn M. C., De La Fuente R., Cigudosa J. C., Lloyd A. C., Bernad A., Spontaneous human adult stem cell transformation Cancer Research 2005 65 8 3035 3039 (Pubitemid 40524580)
29. Rsland G. V., Svendsen A., Torsvik A., Sobala E., McCormack E., Immervoll H., Mysliwietz J., Tonn J.-C., Goldbrunner R., Lnning P. E., Bjerkvig R., Schichor C., Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation Cancer Research 2009 69 13 5331 5339
30. Rubio D., Garcia S., De la Cueva T., Paz M. F., Lloyd A. C., Bernad A., Garcia-Castro J., Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition Experimental Cell Research 2008 314 4 691 698
31. Garcia S., Martn M. C., de la Fuente R., Cigudosa J. C., Garcia-Castro J., Bernad A., Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells Experimental Cell Research 2010 316 9 1648 1650
32. Torsvik A., Rsland G. V., Svendsen A., Molven A., Immervoll H., McCormack E., Lnning P. E., Primon M., Sobala E., Tonn J. -C., Goldbrunner R., Schichor C., Mysliwietz J., Lah T. T., Motaln H., Knappskog S., Bjerkvig R., Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on trackletter Cancer Research 2010 70 15 6393 6396
33. Bernardo M. E., Zaffaroni N., Novara F., Cometa A. M., Avanzini M. A., Moretta A., Montagna D., Maccario R., Villa R., Daidone M. G., Zuffardi O., Locatelli F., Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms Cancer Research 2007 67 19 9142 9149 (Pubitemid 47535900)
34. Kim J., Kang J. W., Park J. H., Choi Y., Choi K. S., Park K. D., Baek D. H., Seong S. K., Min H.-K., Kim H. S., Biological characterization of long-term cultured human mesenchymal stem cells Archives of Pharmacal Research 2009 32 1 117 126
35. Tarte K., Gaillard J., Lataillade J. -J., Fouillard L., Becker M., Mossafa H., Tchirkov A., Rouard H., Henry C., Splingard M., Dulong J., Monnier D., Gourmelon P., Gorin N. -C., Sensebé L., Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation Blood 2010 115 8 1549 1553
36. Le Blanc K., Rasmusson I., Sundberg B., Gtherstrm C., Hassan M., Uzunel M., Ringdén O., Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 2004 363 9419 1439 1441 (Pubitemid 38586721)
37. Martin J., Uberti J., Soiffer R., Prochymal improves response rates in patients with steroid-refractory acute graft-versus-host disease involving the liver and gut: results of a randomized, placebo-controlled, multicentre phase III trial in GvHDP. Communication Vienna, EBMT, 2010
38. Lazarus H. M., Koc O. N., Devine S. M., Curtin P., Maziarz R. T., Holland H. K., Shpall E. J., McCarthy P., Atkinson K., Cooper B. W., Gerson S. L., Laughlin M. J., Loberiza F. R. Jr., Moseley A. B., Bacigalupo A., Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients Biology of Blood and Marrow Transplantation 2005 11 5 389 398 (Pubitemid 40542932)
39. Taupin P., OTI-010 Osiris Therapeutics/JCR Pharmaceuticals Current Opinion in Investigational Drugs 2006 7 5 473 481 (Pubitemid 43772988)
40. Ning H., Yang F., Jiang M., Hu L., Feng K., Zhang J., Yu Z., Li B., Xu C., Li Y., Wang J., Hu J., Lou X., Chen H., The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study Leukemia 2008 22 3 593 599 (Pubitemid 351386730)
41. Shake J. G., Gruber P. J., Baumgartner W. A., Senechal G., Meyers J., Redmond J. M., Pittenger M. F., Martin B. J., Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects Annals of Thoracic Surgery 2002 73 6 1919 1926 (Pubitemid 34596742)
42. Léobon B., Roncalli J., Joffre C., Mazo M., Boisson M., Barreau C., Calise D., Arnaud E., André M., Pucéat M., Pénicaud L., Prosper F., Planat-Bénard V., Casteilla L., Adipose-derived cardiomyogenic cells: in vitro expansion and functional improvement in a mouse model of myocardial infarction Cardiovascular Research 2009 83 4 757 767
43. Chen S.-L., Fang W.-W., Ye F., Liu Y.-H., Qian J., Shan S.-J., Zhang J.-J., Chunhua R. Z., Liao L.-M., Lin S., Sun J.-P., Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction American Journal of Cardiology 2004 94 1 92 95 (Pubitemid 38813459)
44. Hare J. M., Traverse J. H., Henry T. D., Dib N., Strumpf R. K., Schulman S. P., Gerstenblith G., DeMaria A. N., Denktas A. E., Gammon R. S., Hermiller J. B. Jr., Reisman M. A., Schaer G. L., Sherman W., A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Journal of the American College of Cardiology 2009 54 24 2277 2286
45. TransAtlantic inter-Society Consensus (TASC), Definition and nomenclature for chronic critical limb ischemia Journal of Vascular Surgery 2000 31 S168 S173
46. Tateishi-Yuyama E., Matsubara H., Murohara T., Ikeda U., Shintani S., Masaki H., Amano K., Kishimoto Y., Yoshimoto K., Akashi H., Shimada K., Iwasaka T., Imaizumi T., Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial Lancet 2002 360 9331 427 435
47. Matoba S., Tatsumi T., Murohara T., Imaizumi T., Katsuda Y., Ito M., Saito Y., Uemura S., Suzuki H., Fukumoto S., Yamamoto Y., Onodera R., Teramukai S., Fukushima M., Matsubara H., TACT Follow-up Study Investigators. Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia American Heart Journal 2008 156 5 1010 1018
48. Jones B. J., McTaggart S. J., Immunosuppression by mesenchymal stromal cells: from culture to clinic Experimental Hematology 2008 36 6 733 741 (Pubitemid 351636190)
49. Uccelli A., Moretta L., Pistoia V., Mesenchymal stem cells in health and disease Nature Reviews Immunology 2008 8 9 726 736
50. Dai W., Hale S. L., Martin B. J., Kuang J.-Q., Dow J. S., Wold L. E., Kloner R. A., Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short-and long-term effects Circulation 2005 112 2 214 223 (Pubitemid 40982304)
51. Wolf D., Reinhard A., Krause U., Seckinger A., Katus H. A., Kuecherer H., Hansen A., Stem cell therapy improves myocardial perfusion and cardiac synchronicity: new application for echocardiography Journal of the American Society of Echocardiography 2007 20 5 512 520 (Pubitemid 46678691)
52. Amado L. C., Schuleri K. H., Saliaris A. P., Boyle A. J., Helm R., Oskouei B., Centola M., Eneboe V., Young R., Lima J. A. C., Lardo A. C., Heldman A. W., Hare J. M., Multimodality Noninvasive Imaging Demonstrates In Vivo Cardiac Regeneration After Mesenchymal Stem Cell Therapy Journal of the American College of Cardiology 2006 48 10 2116 2124 (Pubitemid 44738440)
53. Imanishi Y., Saito A., Komoda H., Kitagawa-Sakakida S., Miyagawa S., Kondoh H., Ichikawa H., Sawa Y., Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats Journal of Molecular and Cellular Cardiology 2008 44 4 662 671
54. Du Y.-Y., Zhou S.-H., Zhou T., Su H., Pan H.-W., Du W.-H., Liu B., Liu Q.-M., Immuno-inflammatory regulation effect of mesenchymal stem cell transplantation in a rat model of myocardial infarction Cytotherapy 2008 10 5 469 478
55. Alvarez-Dolado M., Pardal R., Garcia-Verdugo J. M., Fike J. R., Lee H. O., Pfeffer K., Lois C., Morrison S. J., Alvarez-Bullia A., Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes Nature 2003 425 6961 968 973 (Pubitemid 37376928)
56. Inoue S., Popp F. C., Koehl G. E., Piso P., Schlitt H. J., Geissler E. K., Dahlke M. H., Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model Transplantation 2006 81 11 1589 1595 (Pubitemid 43890897)
57. Zhou H. P., Yi D. H., Yu S. Q., Sun G. C., Cui Q., Zhu H. L., Liu J. C., Zhang J. Z., Wu T. J., Administration of donor-derived mesenchymal stem cells can prolong the survival of rat cardiac allograft Transplantation Proceedings 2006 38 9 3046 3051 (Pubitemid 44737988)
58. Puissant B., Barreau C., Bourin P., Clavel C., Corre J., Bousquet C., Taureau C., Cousin B., Abbal M., Laharrague P., Penicaud L., Casteilla L., Blancher A., Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells British Journal of Haematology 2005 129 1 118 129 (Pubitemid 40524060)
59. Yaez R., Lamana M. L., Garca-Castro J., Colmenero I., Ramrez M., Bueren J. A., Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease Stem Cells 2006 24 11 2582 2591 (Pubitemid 44674320)
60. Hoogduijn M. J., Crop M. J., Peeters A. M. A., Van Osch G. J. V. M., Balk A. H. M. M., Ijzermans J. N. M., Weimar W., Baan C. C., Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities Stem Cells and Development 2007 16 4 597 604 (Pubitemid 47378732)
61. Wolbank S., Peterbauer A., Fahrner M., Hennerbichler S., Van Griensven M., Stadler G., Redl H., Gabriel C., Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue Tissue Engineering 2007 13 6 1173 1183 (Pubitemid 46986718)
62. Cho K.-S., Park H.-K., Park H.-Y., Jin S. J., Jeon S.-G., Kim Y.-K., Hwan J. R., IFATS collection: immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model Stem Cells 2009 27 1 259 265
63. Bochev I., Elmadjian G., Kyurkchiev D., Tzvetanov L., Altankova I., Tivchev P., Kyurkchiev S., Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro Cell Biology International 2008 32 4 384 393
64. Mias C., Trouche E., Seguelas M.-H., Calcagno F., Dignat-George F., Sabatier F., Piercecchi-Marti M.-D., Daniel L., Bianchi P., Calise D., Bourin P., Parini A., Cussac D., Ex vivo pretreatment with melatonin improves survival, proangiogenic/ mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidney Stem Cells 2008 26 7 1749 1757
65. Miyahara Y., Nagaya N., Kataoka M., Yanagawa B., Tanaka K., Hao H., Ishino K., Ishida H., Shimizu T., Kangawa K., Sano S., Okano T., Kitamura S., Mori H., Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction Nature Medicine 2006 12 4 459 465
66. Meyerrose T. E., De Ugarte D. A., Hofling A. A., Herrbrich P. E., Cordonnier T. D., Shultz L. D., Eagon J. C., Wirthlin L., Sands M. S., Hedrick M. A., Nolta J. A., In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models Stem Cells 2007 25 1 220 227 (Pubitemid 46052993)
67. Madonna R., Rinaldi L., Rossi C., Geng Y.-J., De Caterina R., Prostacyclin improves transcoronary myocardial delivery of adipose tissue-derived stromal cells European Heart Journal 2006 27 17 2054 2061 (Pubitemid 44412810)