New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3777-3786

  Andrzejak, Virginie ^a   Muccioli, Giulio G ^b   Body Malapel, Mathilde ^c   El Bakali, Jamal ^a   Djouina, Madjid ^c   Renault, Nicolas ^d   Chavatte, Philippe ^d   Desreumaux, Pierre ^c   Lambert, Didier M ^b   Millet, Régis ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSITÉ DE LILLE   (France)

^d UNIV LILLE   (France)

Author keywords

Cannabinoids; FAAH; FAAH modeling; IBD; Isoxazole

Indexed keywords

3 CARBOXAMIDO 5 ARYL ISOXAZOLE; 5 (4 BROMOPHENYL) N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 5 (BIPHEN 4 YL) (3 BENZYL)ISOXAZOLE 3 CARBOXAMIDE; 5 (BIPHEN 4 YL) (3 PHENETHYL)ISOXAZOLE 3 CARBOXAMIDE; 5 (BIPHENYL 4 YL) N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 5 (NAPHT 2 YL) N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 5 (PHENANTHR 2 YL) N (3 PHENYLPROPYL)ISOXAZOLE 5 CARBOXAMIDE; 5 4 TOLYL N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 5 [4 (TRIFLUOROMETHYL)PHENYL] N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 5 PHENYL N (3 PHENYLPROPYL)ISOXAZOLE 3 CARBOXAMIDE; 7 PHENYL 1 [5 (2 PYRIDINYL) 2 OXAZOLYL] 1 HEPTANONE; AMIDE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ENDOCANNABINOID; FATTY ACID AMIDASE INHIBITOR; MESALAZINE; N (BENZO[D][1,3]DIOXOL 5 YL) 5 (BIPHEN 4 YL)ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 (4 BROMOPHENYL) ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 (BIPHEN 2 YL) ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 (BIPHEN 3 YL) ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 (BIPHENYL 4 YL) ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 (NAPHT 2 YL) ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 [4 (TRIFLUOROMETHYL)PHENYL] ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 P TOLYL ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 5 PHENYL ISOXAZOLE 3 CARBOXAMIDE; N [2 (BENZO[D][1,3]DIOXOL 5 YL)METHYL] 5 (BIPHEN 4 YL) ISOXAZOLE 3 CARBOXAMIDE; PF 622; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN;

AMIDOHYDROLASES; ANIMALS; COLITIS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 79958243972     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.057     Document Type: Article

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