Design and development of nasal mucoadhesive microspheres containing tramadol HCl for CNS targeting

Drug Delivery

Volumn 18, Issue 5, 2011, Pages 353-360

  Belgamwar, Veena S ^a   Patel, Hitesh S ^a   Joshi, Ashwini S ^a   Agrawal, Anshuman ^b   Surana, Sanjay J ^a   Tekade, Avinash R ^a  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^b Shri Siddhivinayak Ganapati Cancer Hospital   (India)

Author keywords

CNS targeting; gamma scintigraphy; HPMC E15; nasal drug delivery; spray drying; Tramadol HCl

Indexed keywords

MICROSPHERE; POLYMER; TRAMADOL;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG TARGETING; HISTOPATHOLOGY; IN VITRO STUDY; MUCOADHESION; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, INTRANASAL; ANALGESICS, OPIOID; ANIMALS; BRAIN; DRUG DELIVERY SYSTEMS; EXCIPIENTS; METHYLCELLULOSE; MICROSCOPY, ACOUSTIC; MICROSPHERES; NASAL MUCOSA; PARTICLE SIZE; RABBITS; TISSUE DISTRIBUTION; TRAMADOL;

EID: 79958230035     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2011.557787     Document Type: Article

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