Radiotherapy and wound healing: Principles, management and prospects (review)

Oncology Reports

Volumn 26, Issue 2, 2011, Pages 299-307

  Gieringer, Matthias ^a   Gosepath, Jan ^a   Naim, Ramin ^a  

^a DR HORST SCHMIDT KLINIKEN   (Germany)

Author keywords

Fibroblasts; Keloid; Radiotherapy; Scaring; Wound healing

Indexed keywords

AMIFOSTINE; BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SUCRALFATE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANGIOGENESIS; BRACHYTHERAPY; CANCER RADIOTHERAPY; CHRONIC WOUND; GENE DELIVERY SYSTEM; GENE THERAPY; HUMAN; INFLAMMATION; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION DERMATITIS; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION PROTECTION; REVIEW; RISK FACTOR; SKIN FIBROSIS; SKIN FLAP; SKIN GRAFT; SKIN MANIFESTATION; SKIN SURGERY; SKIN ULCER; TISSUE REGENERATION; TISSUE REPAIR; WOUND CARE; WOUND HEALING;

HUMANS; RADIATION ONCOLOGY; RADIOTHERAPY; SKIN; WOUND HEALING;

EID: 79958200243     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1319     Document Type: Review

References (106)

1. Nuyts S: Defining the target for radiotherapy of head and neck cancer. Cancer Imaging 7 Spec No A: S50-S55, 2007.
2. Sitton E: Early and late radiation-induced skin alterations. Part I: Mechanisms of skin changes. Oncol Nurs Forum 19: 801-807, 1992.
3. Dorr W and Hendry JH: Consequential late effects in normal tissues. Radiother Oncol 61: 223-231, 2001. (Pubitemid 33127227)
4. Bernstein EF, Sullivan FJ, Mitchell JB, Salomon GD and Glatstein E: Biology of chronic radiation effect on tissues and wound healing. Clin Plast Surg 20: 435-453, 1993. (Pubitemid 23173096)
5. Collen EB and Mayer MN: Acute effects of radiation treatment: skin reactions. Can Vet J 47: 931-935, 2006. (Pubitemid 44540858)
6. Habel DW: Surgical complications in irradiated patients. Arch Otolaryngol 82: 382-386, 1965.
7. Neta R: Modulation of radiation damage by cytokines. Stem Cells 15 (Suppl 2): S87-S94, 1997.
8. Hom DB, Unger GM, Pernell KJ and Manivel JC: Improving surgical wound healing with basic fibroblast growth factor after radiation. Laryngoscope 115: 412-422, 2005. (Pubitemid 40327985)
9. Adamietz IA: Radiotherapy. Front Radiat Ther Oncol 42: 164-172, 2010.
10. Gerber DE and Chan TA: Recent advances in radiation therapy. Am Fam Physician 78: 1254-1262, 2008.
11. Minniti G, Amichetti M and Enrici RM: Radiotherapy and radiosurgery for benign skull base meningiomas. Radiat Oncol 4: 42, 2009.
12. Thomas MR: Brachytherapy: here today, gone tomorrow? Heart 91 (Suppl 3): iii32-iii34, 2005.
13. Kassis AI: Therapeutic radionuclides: biophysical and radiobiologic principles. Semin Nucl Med 38: 358-366, 2008.
14. Ward JF: DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog Nucleic Acid Res Mol Biol 35: 95-125, 1988.
15. Alsner J, Andreassen CN and Overgaard J: Genetic markers for prediction of normal tissue toxicity after radiotherapy. Semin Radiat Oncol 18: 126-135, 2008. (Pubitemid 351296451)
16. Bentzen SM and Overgaard M: Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol 20: 159-165, 1991.
17. Perona R and Sanchez-Perez I: Control of oncogenesis and cancer therapy resistance. Br J Cancer 90: 573-577, 2004. (Pubitemid 38297192)
18. Holscher T, Bentzen SM and Baumann M: Influence of connective tissue diseases on the expression of radiation side effects: a systematic review. Radiother Oncol 78: 123-130, 2006. (Pubitemid 43344170)
19. Brizel DM, Sibley GS, Prosnitz LR, Scher RL and Dewhirst MW: Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38: 285-289, 1997. (Pubitemid 27318643)
20. Harrison LB, Chadha M, Hill RJ, Hu K and Shasha D: Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 7: 492-508, 2002. (Pubitemid 36008998)
21. Hansen AE, Kristensen AT, Law I, Jorgensen JT and Engelholm SA: Hypoxia inducible factors-regulation and comparative aspects in tumourigenesis. Vet Comp Oncol 9: 16-37, 2011.
22. Smets EM, Garssen B, Schuster-Uitterhoeve AL and De Haes JC: Fatigue in cancer patients. Br J Cancer 68: 220-224, 1993. (Pubitemid 23229416)
23. Robinson DW: Surgical problems in the excision and repair of radiated tissue. Plast Reconstr Surg 55: 41-49, 1975.
24. Chabchoub I, Gharbi O, Remadi S, et al: Postirradiation osteosarcoma of the maxilla: a case report and current review of literature. J Oncol 2009: 876138, 2009.
25. Tahir M, Hendry P, Baird L, Qureshi NA, Ritchie D and Whitford P: Radiation induced angiosarcoma a sequela of radiotherapy for breast cancer following conservative surgery. Int Semin Surg Oncol 3: 26, 2006.
26. Frieben A: Demonstration eines Cancroids des rechten Handrückens, das sich nach langandauernder Einwirkung von Röntgenstrahlen entwickelt hatte. Fortschr Röntenstr 6: 106-111, 1902.
27. Knighton DR, Hunt TK, Thakral KK and Goodson WH III: Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis. Ann Surg 196: 379-388, 1982. (Pubitemid 12030715)
28. Mazzucco L, Borzini P and Gope R: Platelet-derived factors involved in tissue repair-from signal to function. Transfus Med Rev 24: 218-234, 2010.
29. Nurden AT, Nurden P, Sanchez M, Andia I and Anitua E: Platelets and wound healing. Front Biosci 13: 3532-3548, 2008. (Pubitemid 351594702)
30. Oncul O, Yildiz S, Gurer US, et al: Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections. J Infect 54: 250-256, 2007. (Pubitemid 46238168)
31. Ghosh K, Ren XD, Shu XZ, Prestwich GD and Clark RA: Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Eng 12: 601-613, 2006. (Pubitemid 43673465)
32. Eming SA, Krieg T and Davidson JM: Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 127: 514-525, 2007.
33. Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 320: 365-376, 1989.
34. Gieringer M, Elliott K, Gosepath J and Naim R: Keloids: fundamental principles and prospects (Review). Mol Med Rep 3: 13-20, 2010.
35. Stadelmann WK, Digenis AG and Tobin GR: Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176: S26-S38, 1998.
36. Im AR, Park Y and Kim YS: Isolation and characterization of chondroitin sulfates from sturgeon (Acipenser sinensis) and their effects on growth of fibroblasts. Biol Pharm Bull 33: 1268-1273, 2010.
37. Campbell NE, Kellenberger L, Greenaway J, Moorehead RA, Linnerth-Petrik NM and Petrik J: Extracellular matrix proteins and tumor angiogenesis. J Oncol 2010: 586905, 2010.
38. Sevilla C, Dalecki D and Hocking D: Extracellular matrix fibronectin stimulates the self-assembly of microtissues on native collagen gels. Tissue Eng Part A 16: 3805-3819, 2010.
39. Dereure O: Hyaluronic acid and immunity. Ann Dermatol Venereol 137 (Suppl 1): S26-S29, 2010 (In French).
40. Muller K and Meineke V: Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 35: 96-104, 2007. (Pubitemid 46427987)
41. Levenson SM, Geever EF, Crowley LV, Oates JF III, Berard CW and Rosen H: The healing of rat skin wounds. Ann Surg 161: 293-308, 1965.
42. Hayden DM, Forsyth C and Keshavarzian A: The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states. J Surg Pes: Mar 26, 2010 (Epub ahead of print).
43. Grazul-Bilska AT, Johnson ML, Bilski JJ, Redmer DA, Reynolds LP, Abdullah A and Abdullah KM: Wound healing: the role of growth factors. Drugs Today (Barc) 39: 787-800, 2003. (Pubitemid 37500405)
44. Rumalla VK and Borah GL: Cytokines, growth factors, and plastic surgery. Plast Reconstr Surg 108: 719-733, 2001. (Pubitemid 32781226)
45. Naim R, Chang RC, Alfano SS, et al: Targeting TGF-beta1 increases hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cell culture. Regul Pept 130: 75-80, 2005. (Pubitemid 40966025)
46. Matsuu-Matsuyama M, Nakashima M, Shichijo K, Okaichi K, Nakayama T and Sekine I: Basic fibroblast growth factor suppresses radiation-induced apoptosis and TP53 pathway in rat small intestine. Radiat Res 174: 52-61, 2010.
47. Shweiki D, Itin A, Soffer D and Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
48. Han YF, Han YQ, Pan YG, Chen YL and Chai JK: Transplantation of microencapsulated cells expressing VEGF improves angiogenesis in implanted xenogeneic acellular dermis on wound. Transplant Proc 42: 1935-1943, 2010.
49. Bock O, Yu H, Zitron S, Bayat A, Ferguson MW and Mrowietz U: Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars. Acta Derm Venereol 85: 216-220, 2005. (Pubitemid 40695163)
50. Schultz G, Rotatori DS and Clark W: EGF and TGF-alpha in wound healing and repair. J Cell Biochem 45: 346-352, 1991.
51. Buckmire MA, Parquet G, Greenway S and Rolandelli RH: Temporal expression of TGF-beta1, EGF, and PDGF-BB in a model of colonic wound healing. J Surg Res 80: 52-57, 1998. (Pubitemid 28507638)
52. Roberts AB, Sporn MB, Assoian RK, et al: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83: 4167-4171, 1986. (Pubitemid 16057012)
53. Kaklamani VG and Pasche B: Role of TGF-beta in cancer and the potential for therapy and prevention. Expert Rev Anticancer Ther 4: 649-661, 2004. (Pubitemid 39161996)
54. Colwell AS, Yun R, Krummel TM, Longaker MT and Lorenz HP: Keratinocytes modulate fetal and postnatal fibroblast transforming growth factor-beta and Smad expression in co-culture. Plast Reconstr Surg 119: 1440-1445, 2007. (Pubitemid 46559112)
55. Shack RB: Management of radiation ulcers. South Med J 75: 1462-1466, 1982.
56. Wang L, Kwak JH, Kim SI, He Y and Choi ME: Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent path-way in murine mesangial cells. J Biol Chem 279: 33213-33219, 2004. (Pubitemid 39062967)
57. Ishikawa T, Terai H and Kitajima T: Production of a biologically active epidermal growth factor fusion protein with high collagen affinity. J Biochem 129: 627-633, 2001. (Pubitemid 32299286)
58. Haisa M, Okochi H and Grotendorst GR: Elevated levels of PDGF alpha receptors in keloid fibroblasts contribute to an enhanced response to PDGF. J Invest Dermatol 103: 560-563, 1994. (Pubitemid 24314846)
59. Ross R, Raines EW and Bowen-Pope DF: The biology of platelet-derived growth factor. Cell 46: 155-169, 1986. (Pubitemid 16031684)
60. Bernstein EF, Harisiadis L, Salomon GD, et al: Healing impairment of open wounds by skin irradiation. J Dermatol Surg Oncol 20: 757-760, 1994. (Pubitemid 24357087)
61. Soo C, Hu FY, Zhang X, et al: Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol 157: 423-433, 2000. (Pubitemid 30626906)
62. Hsu M, Peled ZM, Chin GS, Liu Wand Longaker MT Ontogeny of expression of transforming growth factor-beta 1 (TGF-beta 1), TGF-beta 3, and TGF-beta receptors I and II in fetal rat fibroblasts and skin. Hast Eeconstr Surg 107: 1787-1794, 2001. (Pubitemid 32577789)
63. Furlong RA, Takehara T, Taylor WG, Nakamura T and Rubin JS: Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable. J Cell Sci 100: 173-177, 1991. (Pubitemid 21925047)
64. Conway K, Ruge F, Price P, Harding KG and Jiang WG: Hepatocyte growth factor regulation: an integral part of why wounds become chronic. Wound Repair Regen 15: 683-692, 2007. (Pubitemid 47493897)
65. Zhu G, Huang L, Song M, et al: Overexpression of hepatocyte growth factor in smooth muscle cells regulates endothelial progenitor cells differentiation, migration and proliferation. Int J Cardiol 138: 70-80, 2010.
66. Schonfelder U, Abel M, Wiegand C, Klemm D, Eisner P and Hipler UC: Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro. Biomaterials 26: 6664-6673, 2005. (Pubitemid 41021759)
67. Palolahti M, Lauharanta J, Stephens RW, Kuusela P and Vaheri A: Proteolytic activity in leg ulcer exudate. Exp Dermatol 2: 29-37, 1993. (Pubitemid 23244485)
68. Olascoaga A, Vilar-Compte D, Poitevin-Chacon A and Contreras-Ruiz J: Wound healing in radiated skin: pathophysiology and treatment options. Int Wound J 5: 246-257, 2008. (Pubitemid 351731667)
69. McLean AS: Early adverse effects of radiation. Br Med Bull 29: 69-73, 1973.
70. Behrends U, Peter RU, Hintermeier-Knabe R, et al: Ionizing radiation induces human intercellular adhesion molecule-1 in vitro. J Invest Dermatol 103: 726-730, 1994. (Pubitemid 24350144)
71. Hallahan DE, Spriggs DR, Beckett MA, Kufe DW and Weichselbaum RR: Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA 86: 10104-10107, 1989. (Pubitemid 20030785)
72. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR and Kufe DW: Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. J Clin Invest 87: 1794-1797, 1991.
73. Goessler UR, Bugert P, Kassner S, et al: In vitro analysis of radiation-induced dermal wounds. Otolaryngol Head Neck Surg 142: 845-850, 2010.
74. West CM, Elliott RM and Burnet NG: The genomics revolution and radiotherapy. Clin Oncol (R Coll Radiol) 19: 470-480, 2007.
75. Fernet M and Hall J: Genetic biomarkers of therapeutic radiation sensitivity. DNA Repair (Amst) 3: 1237-1243, 2004. (Pubitemid 38997967)
76. Riekki R, Jukkola A, Sassi ML, Hoyhtya M, Kallioinen M, Risteli J and Oikarinen A: Modulation of skin collagen metabolism by irradiation: collagen synthesis is increased in irradiated human skin. Br J Dermatol 142: 874-880, 2000. (Pubitemid 30304595)
77. Riekki R, Harvima IT, Jukkola A, Risteli J and Oikarinen A: The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy. Exp Dermatol 13: 364-371, 2004. (Pubitemid 38868209)
78. Autio P, Saarto T, Tenhunen M, Elomaa I, Risteli J and Lahtinen T: Demonstration of increased collagen synthesis in irradiated human skin in vivo. Br J Cancer 77: 2331-2335, 1998. (Pubitemid 28263962)
79. Popanda O, Marquardt JU, Chang-Claude J and Schmezer P: Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res 667: 58-69, 2009.
80. Kishore U, Bernal AL, Kamran MF, Saxena S, Singh M, Sarma PU, Madan T and Chakraborty T: Surfactant proteins SP-A and SP-D in human health and disease. Arch Immunol Ther Exp (Warza) 53: 399-417.
81. Barendsen GW: Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8: 1981-1997, 1982.
82. Yu CX, Amies CJ and Svatos M: Hanning and delivery of intensity-modulated radiation therapy. Med Phys 35: 5233-5241, 2008.
83. Nath SK, Simpson DR, Rose BS and Sandhu AP: Recent advances in image-guided radiotherapy for head and neck carcinoma. J Oncol 2009: 752135, 2009.
84. Bolderston A, Lloyd NS, Wong RK, Holden L and Robb-Blenderman L: The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer 14: 802-817, 2006. (Pubitemid 44060993)
85. Bostrom A, Lindman H, Swartling C, Berne B and Bergh J: Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 59: 257-265, 2001. (Pubitemid 32429573)
86. Rashid MA, Akita S, Razzaque MS, et al: Coadministration of basic fibroblast growth factor and sucrose octasulfate (sucralfate) facilitates the rat dorsal flap survival and viability. Plast Reconstr Surg 103: 941-948, 1999. (Pubitemid 29109083)
87. Yeh BK, Eliseenkova AV, Hotnikov AN, et al: Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate. Mol Cell Biol 22: 7184-7192, 2002.
88. Kouvaris J, Kouloulias V, Kokakis J, Matsopoulos G, Myrsini B and Vlahos L: The cytoprotective effect of amifostine in acute radiation dermatitis: a retrospective analysis. Eur J Dermatol 12: 458-462, 2002. (Pubitemid 35205135)
89. Adams DC and Ramsey ML: Grafts in dermatologic surgery: review and update on full- and split-thickness skin grafts, free cartilage grafts, and composite grafts. Dermatol Surg 31: 1055-1067, 2005. (Pubitemid 44796345)
90. McGregor IA and Morgan G: Axial and random pattern flaps. Br J Hast Surg 26: 202-213, 1973.
91. Weum S, De Weerd L, Klein S and Hage JJ: Soft tissue defects treated with perforator flaps. Tidsskr Nor Laegeforen 128: 313-315, 2008 (In Norwegian).
92. Chu EA and Byrne PJ: Local flaps I: bilobed, rhombic, and cervicofacial. Facial Hast Surg Clin North Am 17: 349-360, 2009.
93. Issing PR, Kempf HG, Heppt W, Schonermark M and Lenarz T: Reconstructive surgery in the head-neck area with regional and free tissue transfer. Laryngorhinootologie 75: 476-482, 1996 (In German). (Pubitemid 26294810)
94. El Marakby HH: The reliability of pectoralis major myscutaneous flap in head and neck reconstruction. J Egypt Natl Canc Inst 18: 41-50, 2006.
95. Krag C, De Rose G, Lyczakowski T, Freeman CR and Shapiro SH: Free flaps and irradiated recipient vessels: an experimental study in rabbits. Br J Hast Surg 35: 328-336, 1982. (Pubitemid 13245871)
96. Mulholland S, Boyd JB, McCabe S, Gullane P, Rotstein L, Brown D and Yoo J: Recipient vessels in head and neck microsurgery: radiation effect and vessel access. Plast Reconstr Surg 92: 628-632, 1993. (Pubitemid 23260923)
97. Tattini C, Manchio J, Zaporojan V, Carderelli G, Bonassar L, Spangenberger A and Weinzweig J: Role of TGF-beta and FGF in the treatment of radiation-impaired wounds using a novel drug delivery system. Hast Reconstr Surg 122: 1036-1045, 2008.
98. Fuks Z, Persaud RS, Alfieri A, et al: Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res 54: 2582-2590, 1994. (Pubitemid 24173742)
99. Payne WG, Ochs DE, Meltzer DD, Hill DP, Mannari RJ, Robson LE and Robson MC: Long-term outcome study of growth factor-treated pressure ulcers. Am J Surg 181: 81-86, 2001. (Pubitemid 32209128)
100. Levy RJ, Goldstein SA and Bonadio J: Gene therapy for tissue repair and regeneration. Adv Drug Deliv Rev 33: 53-69, 1998. (Pubitemid 28403536)
101. Matrai J, Chuah MK and van den Driessche T: Preclinical and clinical progress in hemophilia gene therapy. Curr Opin Hematol 17: 387-392, 2010.
102. Teschendorf C, Emons B, Muzyczka N, Graeven U and Schmiegel W: Efficacy of recombinant adeno-associated viral vectors serotypes 1, 2, and 5 for the transduction of pancreatic and colon carcinoma cells. Anticancer Res 30: 1931-1935, 2010.
103. Erlwein O and McClure MO: Progress and prospects: Foamy virus vectors enter a new age. Gene Ther 17: 1423-1429, 2010.
104. Jeschke MG, Herndon DN, Baer W, Barrow RE and Jauch KW: Possibilities of non-viral gene transfer to improve cutaneous wound healing. Curr Gene Ther 1: 267-278, 2001.
105. Dickens S, van den BS, Hendrickx B, Verdonck K, Luttun A and Vranckx J: Non-viral gene therapy strategies for keratinocytes, fibroblasts and endothelial progenitor cells for ex vivo gene transfer to skin wounds. Tssue Eng Part C Methods 16: 1601-1608, 2010.
106. Branski LK, Pereira CT, Herndon DN and Jeschke MG: Gene therapy in wound healing: present status and future directions. Gene Ther 14: 1-10, 2007. (Pubitemid 44942860)