Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway

Biochemical and Biophysical Research Communications

Volumn 409, Issue 3, 2011, Pages 465-469

  D'Ambrosio, Steven M ^a,c   Han, Chunhua ^a   Pan, Li ^b   Douglas Kinghorn, A ^b   Ding, Haiming ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Aliphatic acetogenins (alkanols); Avocado fruit; CHCl3 soluble extract; EGFR; ERK1 2; Oral cancer

Indexed keywords

2,4 DIHYDROXYHEPTADEC 16 ENYL ACETATE; 2,4 DIHYDROXYHEPTADEC 16 YNYL ACETATE; ACETOGENIN; ANTINEOPLASTIC AGENT; AVOCADO EXTRACT; CHLOROFORM; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AVOCADO; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; FRACTIONATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

ACETOGENINS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; FATTY ACIDS, UNSATURATED; FRUIT; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOUTH NEOPLASMS; PERSEA; PLANT EXTRACTS; RAF KINASES; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

PERSEA AMERICANA;

EID: 79958183334     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.027     Document Type: Article

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