Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy

International Journal of Cardiology

Volumn 149, Issue 3, 2011, Pages 372-376

  Tay, Edgar L W ^a   Papaphylactou, Maria ^a   Diller, Gerhard Paul ^a   Alonso Gonzalez, Rafael ^a   Inuzuka, Ryo ^a   Giannakoulas, Georgios ^a   Harries, Carl ^a   Wort, Stephen John ^a   Swan, Lorna ^a   Dimopoulos, Konstantinos ^a,b   Gatzoulis, Michael A ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Congenital heart disease; Eisenmenger syndrome; Phosphodiesterase inhibitor; Pulmonary arterial hypertension; Right to left shunts

Indexed keywords

PARACETAMOL; SILDENAFIL;

6 MINUTE WALK TEST; ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; EISENMENGER COMPLEX; EXERCISE; FEMALE; FLUSHING; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; HEART HEMODYNAMICS; HEART RATE; HUMAN; LUNG COMPLIANCE; MALE; MYALGIA; NOSE CONGESTION; OXYGEN SATURATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY HYPERTENSION; QUALITY OF LIFE; QUESTIONNAIRE; RHINORRHEA; SIDE EFFECT; TRANSTHORACIC ECHOCARDIOGRAPHY; WALKING;

ADMINISTRATION, ORAL; ADULT; EISENMENGER COMPLEX; EXERCISE TOLERANCE; FEMALE; HUMANS; MALE; PIPERAZINES; PROSPECTIVE STUDIES; PURINES; QUALITY OF LIFE; QUESTIONNAIRES; SULFONES; TREATMENT OUTCOME; VASODILATOR AGENTS; YOUNG ADULT;

EID: 79958157049     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.02.020     Document Type: Article

References (21)

1. Wood P. The Eisenmenger syndrome or pulmonary hypertension with reversed central shunt. Br Med J 1958;2:755-62.
2. Daliento L, Somerville J, Presbitero P, et al. Eisenmenger syndrome. Factors relating to deterioration and death. Eur Heart J 1998;19:1845-55.
3. Lane DA, Lip GY, Millane TA. Quality of life in adults with congenital heart disease. Heart 2002;88:71-5. (Pubitemid 34665008)
4. Beghetti M, Galie N. Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. J Am Coll Cardiol 2009;53:733-40.
5. Dimopoulos K, Giannakoulas G, Wort SJ, Gatzoulis MA. Pulmonary arterial hypertension in adults with congenital heart disease: distinct differences from other causes of pulmonary arterial hypertension and management implications. Curr Opin Cardiol 2008;23:545-54.
6. Galie N, Manes A, Palazzini M, et al. Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome. Drugs 2008;68:1049-66. (Pubitemid 351693675)
7. Chau EM, Fan KY, Chow WH. Effects of chronic sildenafil in patients with Eisenmenger syndrome versus idiopathic pulmonary arterial hypertension. Int J Cardiol 2007;120:301-5. (Pubitemid 47069563)
8. Garg N, Sharma MK, Sinha N. Role of oral sildenafil in severe pulmonary arterial hypertension: clinical efficacy and dose response relationship. Int J Cardiol 2007;120:306-13. (Pubitemid 47069567)
9. Singh TP, Rohit M, Grover A, Malhotra S, Vijayvergiya R. A randomized, placebo-controlled, double-blind, crossover study to evaluate the efficacy of oral sildenafil therapy in severe pulmonary artery hypertension. Am Heart J 2006;151:851:e851-5.
10. Lim ZS, Salmon AP, Vettukattil JJ, Veldtman GR. Sildenafil therapy for pulmonary arterial hypertension associated with atrial septal defects. Int J Cardiol 2007;118:178-82. (Pubitemid 46604774)
11. Mukhopadhyay S, Sharma M, Ramakrishnan S, et al. Phosphodiesterase-5 inhibitor in Eisenmenger syndrome: a preliminary observational study. Circulation 2006;114:1807-10. (Pubitemid 44673355)
12. McKenna SP, Doughty N, Meads DM, Doward LC, Pepke-Zaba J. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR): a measure of health-related quality of life and quality of life for patients with pulmonary hypertension. Qual Life Res 2006;15:103-15. (Pubitemid 43097591)
13. Diller GP, Dimopoulos K, Okonko D, et al. Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation 2005;112:828-35. (Pubitemid 41170068)
14. Dimopoulos K, Okonko DO, Diller GP, et al. Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation 2006;113:2796-802. (Pubitemid 44305291)
15. Vongpatanasin W, Brickner ME, Hillis LD, Lange RA. The Eisenmenger syndrome in adults. Ann Intern Med 1998;128:745-55. (Pubitemid 28204867)
16. Broberg C, Ujita M, Babu-Narayan S, et al. Massive pulmonary artery thrombosis with haemoptysis in adults with Eisenmenger's syndrome: a clinical dilemma. Heart 2004;90:e63.
17. Broberg CS, Ujita M, Prasad S, et al. Pulmonary arterial thrombosis in eisenmenger syndrome is associated with biventricular dysfunction and decreased pulmonary flow velocity. J Am Coll Cardiol 2007;50:634-42. (Pubitemid 47199004)
18. Silversides CK, Granton JT, Konen E, Hart MA, Webb GD, Therrien J. Pulmonary thrombosis in adults with Eisenmenger syndrome. J Am Coll Cardiol 2003;42:1982-7. (Pubitemid 37485576)
19. Dimopoulos K, Diller GP, Koltsida E, et al. Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease. Circulation 2008;117:2320-8. (Pubitemid 351681557)
20. Gomberg-Maitland M, Thenappan T, Rizvi K, Chandra S, Meads DM, McKenna SP. United States validation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR). J Heart Lung Transplant 2008;27:124-30.
21. Coats AJ. Ethical authorship and publishing. Int J Cardiol 2009;131:149-50.