Thiothymidine combined with UVA as a potential novel therapy for bladder cancer

British Journal of Cancer

Volumn 104, Issue 12, 2011, Pages 1869-1876

  Pridgeon, S W ^a,e   Heer, R ^a,d   Taylor, G A ^a   Newell, D R ^a   O'Toole, K ^a   Robinson, M ^b   Xu, Y Z ^c   Karran, P ^c   Boddy, A V ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Royal Victoria Inf Irmary ^*  (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d FREEMAN HOSPITAL   (United Kingdom)

^e ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

bladder cancer; DNA damage; raltitrexed; Thiothymidine; UVA

Indexed keywords

4 THIOTHYMIDINE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RALTITREXED; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CHEMORADIOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA SYNTHESIS; DRUG UPTAKE; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRAVIOLET A RADIATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DNA DAMAGE; FEMALE; HUMANS; QUINAZOLINES; RADIATION-SENSITIZING AGENTS; RATS; RATS, INBRED F344; THIOPHENES; THYMIDINE; ULTRAVIOLET THERAPY; URINARY BLADDER NEOPLASMS;

EID: 79958146238     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.180     Document Type: Article

References (22)

1. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A, Palou-Redorta J, European Association of Urology (EAU) (2008) EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol 54(2): 303-314
2. CRUK Cancer Statistics (2010) http://info.cancerresearchuk.org/ cancerstats/incidence
3. Hartley JM, Spanswick VJ, Gander M, Giacomini G, Whelan J, Souhami RL, Hartley JA (1999) Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay. Clin Cancer Res 5(3): 507-512 (Pubitemid 29131958)
4. Jackson RC, Jackman AL, Calvert AH (1983) Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6- quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells. Biochem Pharmacol 32(24): 3783-3790 (Pubitemid 14212206)
5. Kameyama S, Kawamata H, Kawai K, Oyasu R (1993) A new in vivo model for studying invasion and metastasis of rat and human bladder carcinomas. Carcinogenesis 14(8): 1531-1535 (Pubitemid 23249354)
6. Kawamata H, Kameyama S, Nan L, Kawai K, Oyasu R (1993) Effect of epidermal growth factor and transforming growth factor beta 1 on growth and invasive potentials of newly established rat bladder carcinoma cell lines. Int J Cancer 55(6): 968-973 (Pubitemid 24005343)
7. Knowles MA (2008) Molecular pathogenesis of bladder cancer. Int J Clin Onc 13(4): 287-297
8. Liu J, Taylor JS (1998) Template-directed photoligation of oligodeoxyr-ibonucleotides via 4-thiothymidine. Nucleic Acids Res 26(13): 3300-3304 (Pubitemid 28288933)
9. Massey A, Xu YZ, Karran P (2001) Photoactivation of DNA thiobases as a potential novel therapeutic option. Curr Biol 11(14): 1142-1146 (Pubitemid 32675769)
10. Mitrovski B, Pressacco J, Mandelbaum S, Erlichman C (1994) Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells. Cancer Chemother Pharmacol 35(2): 109-114 (Pubitemid 24359730)
11. Nikiforov TT, Connolly BA (1992) Oligodeoxynucleotides containing 4-thiothymidine and 6-thiodeoxyguanosine as affinity labels for the Eco RV restriction endonuclease and modification methylase. Nucleic Acids Res 20(6): 1209-1214
12. Parker SL, Tong T, Bolden S, Wingo PA (1996) Cancer statistics, 1996. CA Cancer J Clin 46(1): 5-27 (Pubitemid 26043582)
13. Pressacco J, Mitrovski B, Erlichman C, Hedley DW (1995) Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression. Cancer Res 55(7): 1505-1508
14. Reelfs O, Xu YZ, Massey A, Karran P, Storey A (2007) Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status. Mol Cancer Ther 6(9): 2487-2495 (Pubitemid 47480414)
15. Rigby CC, Franks LM (1970) A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure. Br J Cancer 24(4): 746-754
16. Shariat SF, Karakiewicz PI, Palapattu GS, Lotan Y, Rogers CG, Amiel GE, Vazina A, Gupta A, Bastian PJ, Sagalowsky AI, Schoenberg MP, Lerner SP (2003) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the bladder cancer research forum. J Urol 176(6): 2414-2422
17. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82(13): 1107-1112 (Pubitemid 20213250)
18. Soloway MS, deKernion JB, Rose D, Persky L (1973) Effect of chemotherapeutic agents on bladder cancer: a new animal model. Surg Forum 24: 542-544
19. Sylvester RJ, van der Meijden AP, Lamm DL (2002) Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials. J Urol 168(5): 1964-1970
20. Walther MM (2000) The role of photodynamic therapy in the treatment of recurrent superficial bladder cancer. Urol Clin North Am 27(1): 163-170 (Pubitemid 30086008)
21. Warren MA, Murray JB, Connolly BA (1998) Synthesis and characterisation of oligodeoxynucleotides containing thio analogues of (6-4) pyrimidine- pyrimidinone photo-dimers. J Mol Biol 279(1): 89-100 (Pubitemid 28252131)
22. Xiao Z, Brown K, Tulip J, Moore RB (2003) Whole bladder photodynamic therapy for orthotopic superficial bladder cancer in rats: a study of intravenous and intravesical administration of photosensitizers. J Urol 169(1): 352-356 (Pubitemid 35461644)