Development and characterization of an in vitro alpha radiation exposure system

Physics in Medicine and Biology

Volumn 56, Issue 12, 2011, Pages 3645-3658

  Beaton, Lindsay A ^a   Burn, Trevor A ^a   Stocki, Trevor J ^b   Chauhan, Vinita ^b   Wilkins, Ruth C ^b  

^a CARLETON UNIVERSITY   (Canada)

^b HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; BIOLOGICAL EFFECTS; CELL LINES; CULTURE DISHES; DOSE RATE; EXPOSURE SYSTEM; IN-VITRO; LINEAR ENERGY TRANSFER; MICRO BEAMS; MONTE CARLO SIMULATION; OPEN-SOURCE; PARTICLE RADIATION; RELATIVE BIOLOGICAL EFFECTIVENESS; SOURCE CODES; STAINLESS STEEL DISCS; SURVIVAL CURVES;

ALPHA PARTICLES; BAR CODES; CELL CULTURE; COMPUTER SIMULATION; ENERGY TRANSFER; MONTE CARLO METHODS; STAINLESS STEEL;

BIOLOGICAL RADIATION EFFECTS;

ALPHA RADIATION; ARTICLE; CELL LINE; CELL SURVIVAL; CLONOGENIC ASSAY; ELECTROPLATING INDUSTRY; ENVIRONMENTAL EXPOSURE; HUMAN; RADIATION EXPOSURE; RADIOMETRY; REPRODUCIBILITY;

ALPHA PARTICLES; CELL LINE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; ELECTROPLATING; ENVIRONMENTAL EXPOSURE; HUMANS; RADIOMETRY; REPRODUCIBILITY OF RESULTS;

EID: 79958144047     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/12/012     Document Type: Article

References (33)

1. Agostinelli S et al 2003 G4-a simulation toolkit Nucl. Instrum. Methods Phys. Res. A 506 250-303
2. Anderson R M, Stevens D L, Sumption N D, Stuart Townsend K M, Goodhead D T and Hill M A 2007 Effect of linear energy transfer (LET) on the complexity of alpha-particle-induces chromosome aberrations in human CD34+ cells Radiat. Res. 167 541-50 (Pubitemid 351292961)
3. Baskar R, Balajee A S and Geard C R 2007 Effects of low and high LET radiations on bystander human lung fibroblast cell survival Int. J. Radiat. Biol. 83 551-9 (Pubitemid 47035913)
4. BEIR VII, National Research Council 2006 Biological Effects of Ionizing Radiation VII Report: Health Risks from Exposure to Low Levels of Ionizing Radiation (Washington, DC: National Academy Press)
5. Chen J et al 2008 A preliminary radon map for Canada according to health region Radiat. Prot. Dosim. 130 92-4
6. Claesson A K, Stenerlow B, Jacobsson L and Elmroth K 2007 Relative biological effectiveness of the alpha-particle emitter 211-At for double-strand break induction in human fibroblasts Radiat. Res. 167 312-8 (Pubitemid 351292543)
7. Dadachova E 2010 Cancer therapy with alpha-emitters labeled peptides Semin. Nucl. Med. 40 204-8
8. Emfietzoglou D et al 2007 Monte Carlo study of energy deposition by heavy charged particles in sub-cellular volumes Radiat. Prot. Dosim. 126 457-62
9. Esposito G, Antonelli F, Belli M, Campa A, Simone G, Sorrentino E and Tabocchini M A 2009 An alpha-particle irradiator for radiobiological research and its implementation for bystander effect studies Radiat. Res. 172 632-42
10. Firestone R B 1996 Table of Isotopes 8th edn (New York: Wiley)
11. Garcia-Molina R, Abril I, Denton C D, Heredia-Avalos S, Kyriakou I and Emfietzoglou D 2009 Calculated depth-dose distributions for H+ and He+ beams in liquid water Nucl. Instrum. Methods Phys. Res. B 267 2647-52
12. Goodhead D T, Bance D A, Stretch A and Wilkinson R E 1991 A versatile plutonium-238 irradiator for radiobiological studies with alpha-particles (Technical Report) Int. J. Radiat. Biol. 59 195-210
13. Hamza V Z and Mohankumar M N 2009 Cytogenetic damage in human blood lymphocytes exposed in vitro to radon Mutat. Res. 661 1-9
14. Hamza V Z, Kumar P R, Jeevanram R K, Santanam R, Danalaksmi B and Mohankumar M N 2008 A simple method to irradiate blood cells in vitro with radon gas Radiat. Prot. Dosim. 130 343-50
15. Hei T K et al 1997 Mutagenic effects of a single and an exact number of alpha particles in mammalian cells Proc. Natl Acad. Sci. USA 94 3765-70
16. Holland J P, Williamson M J and Lewis J S 2010 Unconventional nuclides for radiopharmaceuticals Mol. Imaging 9 1-20
17. ICRP 2008 Nuclear decay data for dosimetric calculations ICRP Publication Ann. ICRP 38 107
18. International Commission on Radiation Units and Measurements 1970 Linear Energy Transfer ICRU Report No 16 (Bethesda, MD: ICRU)
19. Incerti S et al 2005 A comparison of ray-tracing software for the design of quadrupole microbeam systems Nucl. Instrum. Methods Phys. Res. B 231 76-85
20. Incerti S et al 2006 A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkit Radiat. Prot. Dosim. 122 327-29 (Pubitemid 47090476)
21. Inserti S et al 2009 Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility Radiat. Prot. Dosim. 133 2-11
22. Ishigure N, Nakano T and Enomoto H 1991 A device for in vitro irradiation with alpha-particles using an alpha-emitting radioactive source J. Radiat. Res. 32 404-16
23. Krewski D et al 2006 A combined analysis of North American case-control studies of residential radon and lung cancer J. Toxicol. Environ. Health A 69 533-97
24. Metting N F, Koehler A M, Nagasawa H, Nelson J M and Little J B 1995 Design of a benchtop alpha particle irradiator Health Phys. 68 710-15
25. Nagasawa H and Little J B 1992 Induction of sister chromatid exchanges by extremely low doses of alpha-particles Cancer Res. 52 6394-96
26. Neti P V S V, de Toledo S M, Perumal V, Azzam E I and Howell R W 2004 A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies Radiat. Res. 161 732-38 (Pubitemid 39149582)
27. Nikjoo H, Ueharab S, Emfietzoglouc D and Cucinotta F A 2006 Track-structure codes in radiation research Radiat. Meas. 41 1052-74 (Pubitemid 44792451)
28. Raju R, Eisen Y, Carpenter S and Inkrett W C 1991 Radiobiology of α particles: III. Cell inactivation by α-particle traversals of the cell nucleus Radiat. Res. 128 204-9
29. Roeske J C and Hoggarth M 2007 Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheet Phys. Med. Biol. 52 1909-22 (Pubitemid 46646354)
30. Roos H and Kellerer A M 1989 Design criteria and performance parameters of an alpha irradiation device for cell studies Phys. Med. Biol. 34 1823-32 (Pubitemid 20004950)
31. Thomas P A, Tracy B L, Ping T, Wickstrom M, Sidhu N and Hiebert L 2003 Relative biological effectiveness (RBE) of 210-Po alpha-particles versus x-rays on lethality in bovine endothelial cells Int. J. Radiat. Biol. 79 107-18 (Pubitemid 36183069)
32. Wakeford R 2009 Radiation in the workplace-a review of studies of the risks of occupational exposure to ionising radiation J. Radiol. Prot. 29 A61-79
33. Wang R and Coderre J A 2005 A bystander effect in alpha-particle irradiations of human prostate tumor cells Radiat.Res. 164 711-22 (Pubitemid 41692718)