A single amino acid limits the substrate specificity of thermus thermophilus uridine-cytidine kinase to cytidine

Biochemistry

Volumn 50, Issue 21, 2011, Pages 4597-4607

  Tomoike, Fumiaki ^a   Nakagawa, Noriko ^a,b   Kuramitsu, Seiki ^a,b   Masui, Ryoji ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN Harima Institute Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; CYTIDINE; DE NOVO PATHWAY; HISTIDINE RESIDUES; PHOSPHORYLATION ACTIVITIES; RATE-LIMITING ENZYMES; SALVAGE PATHWAY; SUBSTRATE SPECIFICITY; THERMOPHILUS; THERMUS THERMOPHILUS; THERMUS THERMOPHILUS HB8; THYMIDINE PHOSPHORYLASE;

AMINO ACIDS; BIOCHEMISTRY; ENZYMES; FUNCTIONAL GROUPS; NUCLEOTIDES; PHOSPHORYLATION; STRUCTURAL ANALYSIS;

SUBSTRATES;

CYTIDINE; GLUTAMINE; HISTIDINE; PYRIMIDINE; TYROSINE; URIDINE KINASE;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMUS THERMOPHILUS;

AMINO ACIDS; CHROMATOGRAPHY, ION EXCHANGE; CIRCULAR DICHROISM; CYTIDINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; THERMUS THERMOPHILUS; URIDINE KINASE;

THERMUS THERMOPHILUS;

EID: 79958122774     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102054n     Document Type: Article

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