Simulations to study spatial extent of stimulation and effect of electrode-tissue gap in subretinal implants

Medical Engineering and Physics

Volumn 33, Issue 6, 2011, Pages 755-763

  Kasi, Harsha ^a   Bertsch, Arnaud ^a   Guyomard, Jean Laurent ^b,c   Kolomiets, Bogdan ^b,c,d   Picaud, Serge ^b,c,d,e   Pelizzone, Marco ^f   Renaud, Philippe ^a  

^a EPFL   (Switzerland)

^b INSTITUT DE LA VISION   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^f GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Biomedical microdevices; Electrical subretinal stimulation; Electrode tissue gap; Finite element method; In vivo impedance measurement; Retinal implant; Visual prosthesis

Indexed keywords

BIOMEDICAL MICRODEVICES; ELECTRICAL SUBRETINAL STIMULATION; ELECTRODE-TISSUE GAP; FINITE ELEMENT; IN VIVO IMPEDANCE MEASUREMENT; RETINAL IMPLANTS; VISUAL PROSTHESIS;

COMPUTER SIMULATION; ELECTRIC FIELDS; ELECTROPHYSIOLOGY; FINITE ELEMENT METHOD; MICROELECTRODES; OPHTHALMOLOGY; PROSTHETICS;

TISSUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ELECTRIC FIELD; ELECTRODE; ELECTROSTIMULATION; ENDOPROSTHESIS; EVOKED RESPONSE; FINITE ELEMENT ANALYSIS; HYPOTHESIS; IMPEDANCE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; PROCESS MODEL; RAT; RETINA GANGLION CELL; RETINA PROSTHESIS; TISSUE INTERACTION;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; DIELECTRIC SPECTROSCOPY; ELECTRIC STIMULATION; FINITE ELEMENT ANALYSIS; MICROELECTRODES; PROSTHESES AND IMPLANTS; RATS; RETINA; RETINAL GANGLION CELLS; SENSORY THRESHOLDS; VISUAL PATHWAYS; VISUAL PERCEPTION; VISUAL PROSTHESIS;

EID: 79958109651     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2011.01.015     Document Type: Article

References (38)

1. Ameri H., Ratanapakorn T., Ufer S., Eckhardt H., Humayun M.S., Weiland J.D. Toward a wide-field retinal prosthesis. Journal of Neural Engineering 2009, 6:035002.
2. Marc R.E., Jones B.W., Watt C.B., Strettoi E. Neural remodeling in retinal degeneration. Progress in Retinal and Eye Research 2003, 22(5):607-655.
3. Santos A., Humayun M.S., de Juan E., Greenburg R.J., Marsh M.J., Klock I.B., et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Archives of Ophthalmology 1997, 115:511-515.
4. Kim S.Y., Sadda S., Pearlman J., Humayun M.S., de Juan E., Melia B.M., et al. Morphometric analysis of the macula in eyes with disciform age-related macular degeneration. Retina (Philadelphia, PA) 2002, 22:471-477.
5. Sekirnjak C., Hulse C., Jepson L.H., Hottowy P., Sher A., Dabrowski W., et al. Loss of responses to visual but not electrical stimulation in ganglion cells of rats with severe photoreceptor degeneration. Journal of Neurophysiology 2009, 102:3260-3269.
6. Kolomiets B., Dubus E., Simonutti M., Rosolen S., Sahel J.A., Picaud S. Late histological and functional changes in the P23H rat retina after photoreceptor loss. Neurobiology of Disease 2010, 38:47-58.
7. Humayun M.S. Intraocular retinal prosthesis. Transactions of the American Ophthalmological Society 2001, 99:271-300.
8. Wyatt J., Rizzo J. Ocular implants for the blind. IEEE Spectrum 1996, 33:47-53.
9. Margalit E., Weiland J.D., Clatterbuck R.E., Fujii G.Y., Maia M., Tameesh M., et al. Visual and electrical evoked response recorded from subdural electrodes implanted above the visual cortex in normal dogs under two methods of anesthesia. Journal of Neuroscience Methods 2003, 123:129-137.
10. Chow A.Y., Peachey N.S. The subretinal microphotodiode array retinal prosthesis. Ophthalmic Research 1998, 30:195-198.
11. Stett A., Barth W., Weiss S., Haemmerle H., Zrenner E. Electrical multisite stimulation of the isolated chicken retina. Vision Research 2000, 40:1785-1795.
12. Fried S., Kubow T., Werblin F. Complex synaptic activation of bipolar, amacrine and ganglion cells is elicited with biphasic electrical stimulation. Proceedings of the IEEE International Joint Conference on Neural Networks 2004, 1.
13. Gerhardt M., Alderman J., Stett A. Electric field stimulation of bipolar cells in a degenerated retina-a theoretical study. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2010, 18:1-10.
14. Tsai D., Morley J.W., Suaning G.J., Lovell N.H. Direct activation and temporal response properties of rabbit retinal ganglion cells following subretinal stimulation. Journal of Neurophysiology 2009, 102:2982-2993.
15. Coburn B. Neural modeling in electrical stimulation. Critical Reviews in Biomedical Engineering 1989, 17:133-178.
16. Palanker D., Vankov A., Huie P., Baccus S. Design of a high-resolution optoelectronic retinal prosthesis. Journal of Neural Engineering 2005, 2:S105-S120.
17. Jensen R.J., Rizzo J.F. Responses of ganglion cells to repetitive electrical stimulation of the retina. Journal of Neural Engineering 2007, 4:S1-6.
18. Jensen R.J., Ziv O.R., Rizzo J.F. Responses of rabbit retinal ganglion cells to electrical stimulation with an epiretinal electrode. Journal of Neural Engineering 2005, 2:S16-S21.
19. Sekirnjak C., Hottowy P., Sher A., Dabrowski W., Litke A.M., Chichilnisky E.J. Electrical stimulation of mammalian retinal ganglion cells with multielectrode arrays. Journal of Neurophysiology 2006, 95:3311-3327.
20. Wilke R., Greppmaier U., Harscher A., Benav H., Zrenner E. Factors affecting perceptual thersholds of subretinal electric stimulation in blind volunteers. Investigative Ophthalmology & Visual Science 2010, 51(April (5)):2026.
21. de Balthasar C., Patel S., Roy A., Freda R., Greenwald S., Horsager A., et al. Factors affecting perceptual thresholds in epiretinal prostheses. Investigative Ophthalmology & Visual Science 2008, 49:2303-2314.
22. van Kuyck K., Welkenhuysen M., Arckens L., Sciot R., Nuttin B. Histological alterations induced by electrode implantation and electrical stimulation in the human brain: a review. Neuromodulation 2007, 10:244-261.
23. Heynen H., van Norren D. Origin of the electroretinogram in the intact macaque eye-II. Current source-density analysis. Vision Research 1985, 25:709-715.
24. Jensen R., Rizzo J. Activation of retinal ganglion cells in wild-type and rd1 mice through electrical stimulation of the retinal neural network. Vision Research 2008, 48:1562-1568.
25. Resatz S., Rattay F. Excitability of bipolar and ganglion cells with retinal prosthesis: a modeling study. Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: IEEE 2003, 2039-2042.
26. Cottaris N.P., Elfar S.D. How the retinal network reacts to epiretinal stimulation to form the prosthetic visual input to the cortex. Journal of Neural Engineering 2005, 2:S74-S90.
27. Loudin J.D., Simanovskii D.M., Vijayraghavan K., Sramek C.K., Butterwick A.F., Huie P., et al. Optoelectronic retinal prosthesis: system design and performance. Journal of Neural Engineering 2007, 4(1):S72-S84.
28. Ahuja A.K., Behrend M.R., Kuroda M., Humayun M.S., Weiland J.D. An in vitro model of a retinal prosthesis. IEEE Transactions on Bio-medical Engineering 2008, 55(6):1744-1753.
29. Chow A.Y., Pardue M.T., Chow V.Y., Peyman G.A., Liang C., Perlman J.I., et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2001, 9:86-95.
30. Bonanomi M.T.B.C., Nicoletti A.G.B., Carricondo P.C., Buzalaf F., Kara-José N., Gomes A.M.V., et al. Retinal thickness assessed by optical coherence tomography (OCT) in pseudophakic macular edema. Arquivos Brasileiros de Oftalmologia 2006, 69:539-544.
31. Mercanzini A., Colin P., Bensadoun J.-C., Bertsch A., Renaud P. In vivo electrical impedance spectroscopy of tissue reaction to microelectrode arrays. IEEE Transactions on Bio-medical Engineering 2009, 56:1909-1918.
32. Salzmann J., Linderholm O.P., Guyomard J.-L., Paques M., Simonutti M., Lecchi M., et al. Subretinal electrode implantation in the P23H rat for chronic stimulations. The British Journal of Ophthalmology 2006, 90:1183-1187.
33. Plonsey R., Heppner D.B. Considerations of quasi-stationarity in electrophysiological systems. The Bulletin of Mathematical Biophysics 1967, 29:657-664.
34. Cantrell D.R., Inayat S., Taflove A., Ruoff R.S., Troy J.B. Incorporation of the electrode-electrolyte interface into finite-element models of metal microelectrodes. Journal of Neural Engineering 2008, 5:54-67.
35. Brummer S.B., Turner M.J. Electrochemical considerations for safe electrical stimulation of the nervous system with platinum electrodes. IEEE Transactions on Bio-medical Engineering 1977, 24(1):59-63.
36. Johnson L., Scribner D., Skeath P., Klein R., Ilg D., Perkins K., et al. Impedance-based retinal contact imaging as an aid for the placement of high resolution epiretinal prostheses. Journal of Neural Engineering 2007, 4:S17-S23.
37. Mcmahon MJ, Fine I, Greenwald SH, Horsager A, Palmer G, Mech BV, et al., editors. Electrode impedance as a predictor of electrode-retina proximity and perceptual threshold in a retinal prosthesis. ARVO 2006 Annual Meeting, Fort Lauderdale, FL; 2006.
38. Eckhorn R., Wilms M., Schanze T., Eger M., Hesse L., Eysel U.T., et al. Visual resolution with retinal implants estimated from recordings in cat visual cortex. Vision Research 2006, 46:2675-2690.