The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: Influence of dose escalation/reduction over time

Neurotoxicity Research

Volumn 20, Issue 1, 2011, Pages 97-101

  Terre'Blanche, Gisella ^a   Heyer, Nicolette ^a   Bergh, Jacobus J ^a   Mienie, Lodewyk J ^a   Van Der Schyf, Cornelius J ^b   Harvey, Brian H ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Dose variation; Haloperidol; Striatum; Styrene Phenylglyoxylic acid; Vacuous chewing movements

Indexed keywords

PHENYLGLYOXYLIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; LONG TERM EXPOSURE; MOTOR PERFORMANCE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRIATAL MOTOR TOXICITY; TOXICITY TESTING;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLYOXYLATES; HAZARDOUS SUBSTANCES; MALE; MANDELIC ACIDS; MASTICATION; MOVEMENT DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; STYRENE;

ANIMALIA; PARKINSONIA; RATTUS;

EID: 79958102964     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-010-9222-y     Document Type: Article

References (14)

1. Anand VS, Dewan MJ (1996) Withdrawal-emergent dyskinesia in a patient on risperidone undergoping dosage reduction. Ann Clin Psychiatry 8:179-182 (Pubitemid 26372318)
2. Andreassen OA, Jørgensen HA (2000) Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? Prog Neurobiol 61:525-541
3. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306
4. Chakrabarti SK (2000) Altered regulation of dopaminergic activity and impairment in motor function in rats after subchronic exposure to styrene. Pharmacol Biochem Behav 66:523-532
5. Cherry N, Rodgers B, Venables H, Waldron HA, Wells GG (1981) Acute behavioral effects of styrene exposure: a further analysis. Br J Ind Med 38:346-350 (Pubitemid 12198010)
6. Glenthøj B, Hemmingsen R (1991) Development of vacuous chewing movements in rats: role of housing environment. Life Sci 48:2137-2140
7. Harvey BH, Bester A (2000) Withdrawal-associated changes in peripheral nitrogen oxides and striatal cyclic GMP after chronic haloperidol treatment. Behav Brain Res 111:203-211 (Pubitemid 30326715)
8. Ladefoged O, Lam HR, Ostergaard G, Hansen EV, Hass U, Lund SP, Simonsen L (1998) Toxicity of the styrene metabolite, phenylglyoxylic acid, in rats after three months' oral dosing. Neurotoxicology 19:721-737
9. Manini P, Andreoli R, Poli D, De Palma G, Mutti A, Niessen WM (2002) Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and rat. Rapid Commun Mass Spectrom 16:2230-2248
10. Mienie LJ, Bergh JJ, Bloomquist JR, Castagnoli N, Steyn SJ, Van der Schyf CJ (1999) p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sci 65:535-542 (Pubitemid 29342435)
11. Romanelli A, Falzoi A, Mutti A, Bergamaschi E, Franchini I (1986) Effects of some monocyclic aromatic aromatic solvent and their metabolites on brain dopamine in rabbits. J Appl Toxicol 6:431-436
12. Seeber A, Bruckner T, Triebig G (2009) Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurements. Int Arch Occup Environ Health 82:969-984
13. Steinpreis RE, Parret F, Summ RM, Panos JJ (1997) Effects of clozapine and haloperidol on baseline levels of vacuous jaw movements in aged rats. Behav Brain Res 86:165-169 (Pubitemid 27154260)
14. Sumner SJ, Fennel TR (1994) Review of the metabolic fate of styrene. Crit Rev Toxicol 24:11-13