Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain

FEBS Letters

Volumn 585, Issue 12, 2011, Pages 1979-1984

  Wang, Huajin ^a   Zhang, Jing ^a   Qiu, Wei ^a   Han, Gil Soo ^b   Carman, George M ^b   Adeli, Khosrow ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Brain; Lipid droplet; Lipin; Phosphatidic acid phosphatase

Indexed keywords

DIACYLGLYCEROL; FAT DROPLET; ISOPROTEIN; LIPID LINKED PROTEIN; LIPIN 1 GAMMA PROTEIN; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; CATALYSIS; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; INTRACELLULAR SPACE; LIPID BRAIN LEVEL; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING;

BRAIN; HUMANS; LIPID METABOLISM; LIPIDS; NUCLEAR PROTEINS; PHOSPHATIDATE PHOSPHATASE; PROTEIN ISOFORMS; TRIGLYCERIDES;

EID: 79958087283     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.05.035     Document Type: Article

References (15)

1. J. Donkor, M. Sariahmetoglu, J. Dewald, D.N. Brindley, and K. Reue Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns J. Biol. Chem. 282 2007 3450 3457 (Pubitemid 47084457)
2. 2+-dependent phosphatidate phosphatase enzyme J. Biol. Chem. 281 2006 9210 9218 (Pubitemid 43864636)
3. C.A. Langner, E.H. Birkenmeier, O. Ben-Zeev, M.C. Schotz, H.O. Sweet, M.T. Davisson, and J.I. Gordon The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities J. Biol. Chem. 264 1989 7994 8003 (Pubitemid 19137280)
4. M. Peterfy, J. Phan, P. Xu, and K. Reue Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin Nat. Genet. 27 2001 121 124 (Pubitemid 32044532)
5. J. Phan, and K. Reue Lipin, a lipodystrophy and obesity gene Cell Metab. 1 2005 73 83 (Pubitemid 43960586)
6. M. Bou Khalil The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL J. Lipid Res. 50 2009 47 58
7. Z. Chen, M.C. Gropler, J. Norris, J.C. Lawrence Jr., T.E. Harris, and B.N. Finck Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion Arterioscler. Thromb. Vasc. Biol. 28 2008 1738 1744
8. G.S. Han, and G.M. Carman Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms J. Biol. Chem. 285 2010 14628 14638
9. M. Peterfy, J. Phan, and K. Reue Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis J. Biol. Chem. 280 2005 32883 32889 (Pubitemid 41368337)
10. M. Peterfy, T.E. Harris, N. Fujita, and K. Reue Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes J. Biol. Chem. 285 2010 3857 3864
11. T.E. Harris, T.A. Huffman, A. Chi, J. Shabanowitz, D.F. Hunt, A. Kumar, and J.C. Lawrence Jr. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1 J. Biol. Chem. 282 2007 277 286 (Pubitemid 47076630)
12. T.A. Huffman, I. Mothe-Satney, and J.C. Lawrence Jr. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin Proc. Natl. Acad. Sci. USA 99 2002 1047 1052 (Pubitemid 34106633)
13. M. Ingelmo-Torres Hydrophobic and basic domains target proteins to lipid droplets Traffic 10 2009 1785 1801
14. O. Adeyo, P.J. Horn, S. Lee, D.D. Binns, A. Chandrahas, K.D. Chapman, and J.M. Goodman The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets J. Cell Biol. 192 2011 1043 1055
15. K. Takeuchi, and K. Reue Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Am. J. Physiol. Endocrinol. Metab. 296 2009 E1195 E1209