Prevention and treatment of Clostridium difficile infection

Clinical Medicine, Journal of the Royal College of Physicians of London

Volumn 11, Issue 1, 2011, Pages 75-79

  Gouliouris, Theodore ^a   Brown, Nicholas M ^a   Aliyu, Sani H ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Clostridium difficile; Diarrhoea; Nosocomial infection; Prevention; Treatment

Indexed keywords

CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; METRONIDAZOLE; QUINOLONE DERIVATIVE; VANCOMYCIN; ANTIINFECTIVE AGENT; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL TRANSMISSION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; ENVIRONMENTAL SANITATION; HUMAN; HYGIENE; IMMUNOTHERAPY; INFECTION CONTROL; NONHUMAN; PATHOGENESIS; PROTECTIVE CLOTHING; PSEUDOMEMBRANOUS COLITIS; REVIEW;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; HYGIENE;

EID: 79958058721     PISSN: 14702118     EISSN: 14734893     Source Type: Journal    
DOI: 10.7861/clinmedicine.11-1-75     Document Type: Article

References (20)

1. Shannon-Lowe J, Matheson NJ, Cooke FJ, Aliyu SH. Prevention and medical management of Clostridium difficile infection. BMJ 2010;340:641-6.
2. Kelly CP, LaMont JT. Clostridium difficile - more difficult than ever. N Engl J Med 2008;359:1932-40.
3. Department of Health and Health Protection Agency. Clostridium difficile infection: how to deal with the problem. 2008. www.hpa.org.uk/web/HPAwebFile/ HPAweb-C/1232006607827
4. Saving Lives: reducing infection, delivering clean and safe care. High impact intervention No 7: Care bundle to reduce the risk from Clostridium difficile. 2007. www. clean-safe-care.nhs.uk/toolfiles/79-SL-HII-7-v2.pdf
5. Health Protection Agency. Voluntary surveillance of Clostridium difficile in England, Wales and Northern Ireland, 2009. www.hpa.org.uk/web/HPAwebFile/ HPAweb-C/1266228040791
6. Muto CA, Blank MK, Marsh JW et al. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive 'bundle' approach. Clin Infect Dis 2007;45:1266-73.
7. Cohen SH, Gerding DN, Johnson S et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431-55.
8. Vonberg RP, Kuijper EJ, Wilcox MH et al. Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect 2008;14(Suppl 5):2-20. (Pubitemid 351560386)
9. Owens RC Jr, Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial- associated risk factors for Clostridium difficile infection. Clin Infect Dis 2008;46(Suppl 1):S19-31.
10. Oughton MT, Loo VG, Dendukuri N, Fenn S, Libman MD. Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect Control Hosp Epidemiol 2009;30:939-44.
11. Cooper BS, Stone SP, Kibbler CC et al. Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systematic review of the literature. BMJ 2004;329:533.
12. Planche T, Aghaizu A, Holliman R et al. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis 2008;8:777-84.
13. Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007;45:302-7. (Pubitemid 47101025)
14. Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. Clin Infect Dis 2008;46(Suppl 1):S32-42.
15. Apisarnthanarak A, Razavi B, Mundy LM. Adjunctive intracolonic vancomycin for severe Clostridium difficile colitis: case series and review of the literature. Clin Infect Dis 2002;35:690-6. (Pubitemid 35024729)
16. Lamontagne F, Labbé AC, Haeck O et al. Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain. Ann Surg 2007;245:267-72. (Pubitemid 46148486)
17. van Nood E, Speelman P, Kuijper EJ, Keller JJ. Struggling with recurrent Clostridium difficile infections: is donor faeces the solution? Euro Surveill 2009;14.pii:19316. www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19316
18. Howell MD, Novack V, Grgurich P et al. Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med 2010;170:784-90.
19. Lowy I, Molrine DC, Leav BA et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N Engl J Med 2010;362:197-205.
20. Pillai A, Nelson RL. Probiotics for the treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev 2008;(1):CD004611.