메뉴 건너뛰기




Volumn 5, Issue , 2011, Pages 45-53

The emerging role of ofatumumab in the treatment of chronic lymphocytic leukemia

Author keywords

Anti CD20; CLL; Monoclonal antibodies; Ofatumumab; Targeted therapy

Indexed keywords

ALEMTUZUMAB; CD20 ANTIBODY; CYCLOPHOSPHAMIDE; FLUDARABINE; OBINUTUZUMAB; OCRELIZUMAB; OFATUMUMAB; PENTOSTATIN; RITUXIMAB; VELTUZUMAB;

EID: 79958057037     PISSN: 11795549     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S4087     Document Type: Review
Times cited : (10)

References (73)
  • 2
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446-56.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 3
    • 31544443535 scopus 로고    scopus 로고
    • Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia
    • Binet JL, Caligaris-Cappio F, Catovsky D, et al. Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood. 2006;107:859-61.
    • (2006) Blood , vol.107 , pp. 859-861
    • Binet, J.L.1    Caligaris-Cappio, F.2    Catovsky, D.3
  • 4
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-54.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 5
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348:1764-75.
    • (2003) N Engl J Med , vol.348 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 6
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-7.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 7
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-6.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 8
    • 33644847307 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for riskadapted therapy
    • Byrd JC, Gribben JG, Peterson BL, et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for riskadapted therapy. J Clin Oncol. 2006;24:437-43.
    • (2006) J Clin Oncol , vol.24 , pp. 437-443
    • Byrd, J.C.1    Gribben, J.G.2    Peterson, B.L.3
  • 9
    • 33947544426 scopus 로고    scopus 로고
    • Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: Results from the US Intergroup Phase III Trial E2997
    • Grever MR, Lucas DM, Dewald GW, et al. Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997. J Clin Oncol. 2007;25:799-804.
    • (2007) J Clin Oncol , vol.25 , pp. 799-804
    • Grever, M.R.1    Lucas, D.M.2    Dewald, G.W.3
  • 10
    • 70449497016 scopus 로고    scopus 로고
    • Genomic Aberrations, VH Mutation Status and Outcome after Fludarabine and Cyclophosphamide (FC) or FC Plus Rituximab (FCR) in the CLL8 Trial
    • Stilgenbauer S, Zenz T, Winkler D, et al. Genomic Aberrations, VH Mutation Status and Outcome after Fludarabine and Cyclophosphamide (FC) or FC Plus Rituximab (FCR) in the CLL8 Trial. Blood. 2008:112.
    • (2008) Blood , pp. 112
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3
  • 11
    • 76949091824 scopus 로고    scopus 로고
    • First-Line Treatment with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Improves Overall Survival (OS) in Previously Untreated Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL): Results of a randomized phase III Trial On Behalf of An International Group of Investigators and the German CLL Study Group
    • Hallek M, Fingerle-Rowson G, Fink A, et al. First-Line Treatment with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Improves Overall Survival (OS) in Previously Untreated Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL): results of a randomized phase III Trial On Behalf of An International Group of Investigators and the German CLL Study Group. Blood. 114.
    • Blood , pp. 114
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.3
  • 12
    • 33645969604 scopus 로고    scopus 로고
    • Treatment of relapsed chronic lymphocytic leukemia: Old and new therapies
    • Byrd JC, Lin TS, Grever MR. Treatment of relapsed chronic lymphocytic leukemia: old and new therapies. Semin Oncol. 2006;33:210-9.
    • (2006) Semin Oncol , vol.33 , pp. 210-219
    • Byrd, J.C.1    Lin, T.S.2    Grever, M.R.3
  • 13
    • 77954998779 scopus 로고    scopus 로고
    • Long-Term Survival Analysis of the North American Intergroup Study C9011 Comparing Fludarabine (F) and Chlorambucil (C) in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL)
    • Rai K, Peterson B, Appelbaum F, et al. Long-Term Survival Analysis of the North American Intergroup Study C9011 Comparing Fludarabine (F) and Chlorambucil (C) in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL). Blood. 2009:114.
    • (2009) Blood , pp. 114
    • Rai, K.1    Peterson, B.2    Appelbaum, F.3
  • 14
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000;343:1750-7.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 15
    • 70349490598 scopus 로고    scopus 로고
    • Pentostatin treatment combinations in chronic lymphocytic leukemia
    • Lamanna N, Kay NE. Pentostatin treatment combinations in chronic lymphocytic leukemia. Clin Adv Hematol Oncol. 2009;7:386-92.
    • (2009) Clin Adv Hematol Oncol , vol.7 , pp. 386-392
    • Lamanna, N.1    Kay, N.E.2
  • 16
    • 0344867044 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine (Cladribine) in the treatment of patients with chronic lymphocytic leukemia 55 years old and younger
    • Robak T, Blonski JZ, Urbanska-Rys H, et al. 2-Chlorodeoxyadenosine (Cladribine) in the treatment of patients with chronic lymphocytic leukemia 55 years old and younger. Leukemia. 1999;13:518-23.
    • (1999) Leukemia , vol.13 , pp. 518-523
    • Robak, T.1    Blonski, J.Z.2    Urbanska-Rys, H.3
  • 17
    • 0035282055 scopus 로고    scopus 로고
    • Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian HM, Cortes J, et al. Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol. 2001;19:1414-20.
    • (2001) J Clin Oncol , vol.19 , pp. 1414-1420
    • O'Brien, S.M.1    Kantarjian, H.M.2    Cortes, J.3
  • 18
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet. 2007;370:230-9.
    • (2007) Lancet , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 19
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 2006;107:885-91.
    • (2006) Blood , vol.107 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3
  • 20
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • Flinn IW, Neuberg DS, Grever MR, et al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol. 2007;25:793-8.
    • (2007) J Clin Oncol , vol.25 , pp. 793-798
    • Flinn, I.W.1    Neuberg, D.S.2    Grever, M.R.3
  • 21
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood. 2003;101:6-14.
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 22
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood. 2005; 105:49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 23
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23:4079-88.
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 24
    • 59149090791 scopus 로고    scopus 로고
    • Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia
    • Foon KA, Boyiadzis M, Land SR, et al. Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27: 498-503.
    • (2009) J Clin Oncol , vol.27 , pp. 498-503
    • Foon, K.A.1    Boyiadzis, M.2    Land, S.R.3
  • 25
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood. 2007;109:405-11.
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 26
    • 34249042684 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia
    • Shanafelt TD, Lin T, Geyer SM, et al. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer. 2007;109:2291-8.
    • (2007) Cancer , vol.109 , pp. 2291-2298
    • Shanafelt, T.D.1    Lin, T.2    Geyer, S.M.3
  • 27
    • 75649140955 scopus 로고    scopus 로고
    • How I treat CLL up front
    • Gribben JG. How I treat CLL up front. Blood. 2010;115:187-97.
    • (2010) Blood , vol.115 , pp. 187-197
    • Gribben, J.G.1
  • 28
    • 70350475037 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: Ready for prime time?
    • Delgado J, Milligan DW, Dreger P. Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time? Blood. 2009;114:2581-8.
    • (2009) Blood , vol.114 , pp. 2581-2588
    • Delgado, J.1    Milligan, D.W.2    Dreger, P.3
  • 29
    • 67649600370 scopus 로고    scopus 로고
    • Treatment of fludarabine-refractory chronic lymphocytic leukemia
    • Tsimberidou AM, Keating MJ. Treatment of fludarabine-refractory chronic lymphocytic leukemia. Cancer. 2009;115:2824-36.
    • (2009) Cancer , vol.115 , pp. 2824-2836
    • Tsimberidou, A.M.1    Keating, M.J.2
  • 30
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 2002;99:3554-61.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 31
    • 0036534380 scopus 로고    scopus 로고
    • Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: Implications for clinical trials in this patient population
    • Perkins JG, Flynn JM, Howard RS, et al. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Cancer. 2002;94:2033-9.
    • (2002) Cancer , vol.94 , pp. 2033-2039
    • Perkins, J.G.1    Flynn, J.M.2    Howard, R.S.3
  • 32
    • 0038473993 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of chronic lymphocytic leukemia
    • Mavromatis B, Cheson BD. Monoclonal antibody therapy of chronic lymphocytic leukemia. J Clin Oncol. 2003;21:1874-81.
    • (2003) J Clin Oncol , vol.21 , pp. 1874-1881
    • Mavromatis, B.1    Cheson, B.D.2
  • 33
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S, et al. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood. 2003;101:3413-5.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 34
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma. 2004;45:2269-73.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.I.3
  • 35
    • 71649094833 scopus 로고    scopus 로고
    • Alemtuzumab and Rituximab Combination Therapy for Patients with Untreated CLL-a Phase II Trial
    • Frankfurt O, Hamilton E, Duffey S, et al. Alemtuzumab and Rituximab Combination Therapy for Patients with Untreated CLL-a Phase II Trial. Blood. 2008:112.
    • (2008) Blood , pp. 112
    • Frankfurt, O.1    Hamilton, E.2    Duffey, S.3
  • 36
    • 55749093568 scopus 로고    scopus 로고
    • Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab
    • Zent CS, Call TG, Shanafelt TD, et al. Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab. Cancer. 2008;113: 2110-8.
    • (2008) Cancer , vol.113 , pp. 2110-2118
    • Zent, C.S.1    Call, T.G.2    Shanafelt, T.D.3
  • 37
    • 35148849255 scopus 로고    scopus 로고
    • The natural history of fludarabinerefractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy
    • Tam CS, O'Brien S, Lerner S, et al. The natural history of fludarabinerefractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy. Leuk Lymphoma. 2007;48:1931-9.
    • (2007) Leuk Lymphoma , vol.48 , pp. 1931-1939
    • Tam, C.S.1    O'Brien, S.2    Lerner, S.3
  • 38
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol. 2005;23:4070-8.
    • (2005) J Clin Oncol , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 39
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol. 2010;28:1756-65.
    • (2010) J Clin Oncol , vol.28 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 40
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial
    • Elter T, Borchmann P, Schulz H, et al. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: results of a phase II trial. J Clin Oncol. 2005;23:7024-31.
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3
  • 41
    • 77956267856 scopus 로고    scopus 로고
    • Chemoimmunotherapy with Cyclophosphomide, Fludarabine, Alemtuzumab and Rituximab (CFAR) Is Effective in Relapsed Patients with Chronic Lymphocytic Leukemia (CLL)
    • Badoux X, Keating M, O'Brien S, et al. Chemoimmunotherapy with Cyclophosphomide, Fludarabine, Alemtuzumab and Rituximab (CFAR) Is Effective in Relapsed Patients with Chronic Lymphocytic Leukemia (CLL). Blood. 2009:114.
    • (2009) Blood , pp. 114
    • Badoux, X.1    Keating, M.2    O'Brien, S.3
  • 42
    • 78650017999 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous alemtuzumab after fludarabine and rituximab induction therapy for previously untreated chronic lymphocytic leukemia: Final analysis of CALGB 10101
    • Lin TS, Donohue KA, Byrd JC, et al. Consolidation therapy with subcutaneous alemtuzumab after fludarabine and rituximab induction therapy for previously untreated chronic lymphocytic leukemia: final analysis of CALGB 10101. J Clin Oncol. 2010;28:4500-6.
    • (2010) J Clin Oncol , vol.28 , pp. 4500-4506
    • Lin, T.S.1    Donohue, K.A.2    Byrd, J.C.3
  • 43
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, White CA, et al. IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood. 1997;90:2188-95.
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 44
    • 0034468618 scopus 로고    scopus 로고
    • CD20: A gene in search of a function
    • Riley JK, Sliwkowski MX. CD20: a gene in search of a function. Semin Oncol. 2000;27:17-24.
    • (2000) Semin Oncol , vol.27 , pp. 17-24
    • Riley, J.K.1    Sliwkowski, M.X.2
  • 45
    • 0642312825 scopus 로고    scopus 로고
    • Rituximab (monoclonal anti-CD20 antibody): Mechanisms of action and resistance
    • Smith MR. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene. 2003;22:7359-68.
    • (2003) Oncogene , vol.22 , pp. 7359-7368
    • Smith, M.R.1
  • 46
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol. 2001;19:2153-64.
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 47
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab dose-escalation trial in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol. 2001;19:2165-70.
    • (2001) J Clin Oncol , vol.19 , pp. 2165-2170
    • O'Brien, S.M.1    Kantarjian, H.2    Thomas, D.A.3
  • 48
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti- CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P, Grillo-Lopez AJ, Link BK, et al. Rituximab chimeric anti- CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 1998; 16:2825-33.
    • (1998) J Clin Oncol , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3
  • 49
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood. 2001;98:1326-31.
    • (2001) Blood , vol.98 , pp. 1326-3131
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3
  • 50
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)
    • Winkler U, Jensen M, Manzke O, et al. Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood. 1999;94:2217-24.
    • (1999) Blood , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3
  • 51
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Barton JH, et al. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol. 2003;21: 1746-51.
    • (2003) J Clin Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 52
    • 0036757311 scopus 로고    scopus 로고
    • Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: Results from a Nordic multicentre study
    • Itala M, Geisler CH, Kimby E, et al. Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: results from a Nordic multicentre study. Eur J Haematol. 2002;69:129-34.
    • (2002) Eur J Haematol , vol.69 , pp. 129-134
    • Itala, M.1    Geisler, C.H.2    Kimby, E.3
  • 53
    • 66549130454 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: A report of 57 cases from the Research on Adverse Drug Events and Reports project
    • Carson KR, Evens AM, Richey EA, et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood. 2009;113:4834-40.
    • (2009) Blood , vol.113 , pp. 4834-4840
    • Carson, K.R.1    Evens, A.M.2    Richey, E.A.3
  • 54
    • 59149085061 scopus 로고    scopus 로고
    • Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
    • Yeo W, Chan TC, Leung NW, et al. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab. J Clin Oncol. 2009;27:605-11.
    • (2009) J Clin Oncol , vol.27 , pp. 605-611
    • Yeo, W.1    Chan, T.C.2    Leung, N.W.3
  • 55
    • 70449603373 scopus 로고    scopus 로고
    • GA101, a Novel Humanized Type II CD20 Antibody with Glycoengineered Fc and Enhanced Cell Death Induction, Exhibits Superior Anti-Tumor Efficacy and Superior Tissue B Cell Depletion In Vivo
    • Umana P, Ekkehard M, Bruenker P, et al. GA101, a Novel Humanized Type II CD20 Antibody with Glycoengineered Fc and Enhanced Cell Death Induction, Exhibits Superior Anti-Tumor Efficacy and Superior Tissue B Cell Depletion In Vivo. Blood. 2007;110.
    • (2007) Blood , pp. 110
    • Umana, P.1    Ekkehard, M.2    Bruenker, P.3
  • 56
    • 77951561987 scopus 로고    scopus 로고
    • Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct- and immune effector cell-mediated B-cell cytotoxicity
    • Mossner E, Brunker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct- and immune effector cell-mediated B-cell cytotoxicity. Blood. 2010.
    • (2010) Blood
    • Mossner, E.1    Brunker, P.2    Moser, S.3
  • 57
    • 67649575638 scopus 로고    scopus 로고
    • A Phase I/II Study of RO5072759 (GA101) in Patients with Relapsed/Refractory CD20+ Malignant Disease
    • Salles G, Morschhauser F, Cartron G, et al. A Phase I/II Study of RO5072759 (GA101) in Patients with Relapsed/Refractory CD20+ Malignant Disease. Blood. 2008:112.
    • (2008) Blood , pp. 112
    • Salles, G.1    Morschhauser, F.2    Cartron, G.3
  • 58
    • 76949107685 scopus 로고    scopus 로고
    • Phase I Study of RO5072759 (GA101) in Relapsed/Refractory Chronic Lymphocytic Leukemia
    • Morschhauser F, Cartron G, Lamy T, et al. Phase I Study of RO5072759 (GA101) in Relapsed/Refractory Chronic Lymphocytic Leukemia. Blood. 2009:114.
    • (2009) Blood , pp. 114
    • Morschhauser, F.1    Cartron, G.2    Lamy, T.3
  • 59
    • 63849169216 scopus 로고    scopus 로고
    • Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
    • Milani C, Castillo J. Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Curr Opin Mol Ther. 2009;11:200-7.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 200-207
    • Milani, C.1    Castillo, J.2
  • 60
    • 60849089338 scopus 로고    scopus 로고
    • Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
    • Goldenberg DM, Rossi EA, Stein R, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood. 2009;113:1062-70.
    • (2009) Blood , vol.113 , pp. 1062-1070
    • Goldenberg, D.M.1    Rossi, E.A.2    Stein, R.3
  • 61
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non- Hodgkin lymphomas
    • Teeling JL, French RR, Cragg MS, et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non- Hodgkin lymphomas. Blood. 2004;104:1793-800.
    • (2004) Blood , vol.104 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3
  • 62
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling JL, Mackus WJ, Wiegman LJ, et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol. 2006;177:362-71.
    • (2006) J Immunol , vol.177 , pp. 362-371
    • Teeling, J.L.1    Mackus, W.J.2    Wiegman, L.J.3
  • 63
    • 38349138517 scopus 로고    scopus 로고
    • Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
    • Bleeker WK, Munk ME, Mackus WJ, et al. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br J Haematol. 2008;140:303-12.
    • (2008) Br J Haematol , vol.140 , pp. 303-312
    • Bleeker, W.K.1    Munk, M.E.2    Mackus, W.J.3
  • 64
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood. 2008;111:1094-100.
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 65
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol. 2010;28:1749-55.
    • (2010) J Clin Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 66
    • 77953400882 scopus 로고    scopus 로고
    • Correlation Between Serum Ofatumumab Concentrations, Baseline Patient Characteristics and Clinical Outcomes in Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Single-Agent Ofatumumab
    • Österborg A, Ronn B, Jewell R, et al. Correlation Between Serum Ofatumumab Concentrations, Baseline Patient Characteristics and Clinical Outcomes in Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Single-Agent Ofatumumab. Blood. 2009:114.
    • (2009) Blood , pp. 114
    • Österborg, A.1    Ronn, B.2    Jewell, R.3
  • 67
    • 76149128849 scopus 로고    scopus 로고
    • Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results from a randomized, multicenter, international, two-dose, parallel group, phase II trial
    • Wierda W, Kipps T, Dürig J, et al. Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): results from a randomized, multicenter, international, two-dose, parallel group, phase II trial. Blood. 2009:114.
    • (2009) Blood , pp. 114
    • Wierda, W.1    Kipps, T.2    Dürig, J.3
  • 68
    • 77957375154 scopus 로고    scopus 로고
    • Role of CD20 monoclonal antibodies in previously untreated chronic lymphocytic leukemia
    • Parikh SA, Wierda WG. Role of CD20 monoclonal antibodies in previously untreated chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2010;10 Suppl 1:S27-33.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , Issue.SUPPL. 1
    • Parikh, S.A.1    Wierda, W.G.2
  • 69
    • 47049124865 scopus 로고    scopus 로고
    • First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a phase 1/2 trial
    • Hagenbeek A, Gadeberg O, Johnson P, et al. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial. Blood. 2008;111: 5486-95.
    • (2008) Blood , vol.111 , pp. 5486-5495
    • Hagenbeek, A.1    Gadeberg, O.2    Johnson, P.3
  • 70
    • 77955300283 scopus 로고    scopus 로고
    • Ofatumumab, a Novel Anti-CD20 Monoclonal Antibody for the Treatment of B-Cell Malignancies
    • Cheson BD. Ofatumumab, a Novel Anti-CD20 Monoclonal Antibody for the Treatment of B-Cell Malignancies. J Clin Oncol. 2010;28(21):3525-30
    • (2010) J Clin Oncol , vol.28 , Issue.21 , pp. 3525-3530
    • Cheson, B.D.1
  • 71
    • 33645732715 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia
    • Lamanna N, Kalaycio M, Maslak P, et al. Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia. J Clin Oncol. 2006;24: 1575-81.
    • (2006) J Clin Oncol , vol.24 , pp. 1575-1581
    • Lamanna, N.1    Kalaycio, M.2    Maslak, P.3
  • 72
    • 65749110753 scopus 로고    scopus 로고
    • Bendamustine in Combination with Rituximab (BR) for Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase II Trial of the German CLL Study Group (GCLLSG)
    • Fischer K, Stilgenbauer S, Schweighofer C, et al. Bendamustine in Combination with Rituximab (BR) for Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase II Trial of the German CLL Study Group (GCLLSG). Blood. 2008:112.
    • (2008) Blood , pp. 112
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.3
  • 73
    • 77449133613 scopus 로고    scopus 로고
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd JC, Kipps TJ, Flinn IW, et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood. 2010;115: 489-95.
    • (2010) Blood , vol.115 , pp. 489-495
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.