The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine

Veterinary Research Communications

Volumn 31, Issue 7, 2007, Pages 863-872

  Trailović, Sasa M ^a   Varagic V M ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Convulsions; GABA; Glycine; Ivermectin

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; CHLORIDE CHANNEL; FLUMAZENIL; IVERMECTIN; LIDOCAINE; STRYCHNINE;

ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MEGADOSE; LD 50; MALE; NONHUMAN; PROTEIN FUNCTION; RAT;

ANESTHETICS, LOCAL; ANIMALS; ANTICONVULSANTS; ANTIPARASITIC AGENTS; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA MODULATORS; IVERMECTIN; LETHAL DOSE 50; LIDOCAINE; MALE; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; SEIZURES; STRYCHNINE;

ANIMALIA; ARTHROPODA; MAMMALIA; NEMATODA; RATTUS; STRYCHNOS TOXIFERA;

EID: 34447258393     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-007-0050-3     Document Type: Article

References (28)

1. Adams, R.H., 2001. Veterinary Pharmacology and Therapeutics, 8th edition (Iowa State University Press, Ames, IA), 916-920
2. Arena, J.P., Liu, K.K., Paress, P.S., Frazier, E.G., Cully, D.F., Mrozik, H. and Schaeffer, M., 1995. The mechanism of action of avermectins in Caenorhabditis elegans: Correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. The Journal of Parasitology, 81 (2), 286-294
3. Barat, S.A. and Abdel-Rahman, M.S., 1997. Decreased cocaine and lidocaine induced seizures response by dextromethorphan and DNQX in rats. Brain Research, 756 (1-2), 179-183
4. Bourke, C.A., 1995. The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia. Australian Veterinary Journal, 62 (6), 228-234
5. Brander, G.C., Pugh, D.M., Bywater, R.J. and Jenkins, W.L., 1991. Veterinary Applied Pharmacology and Therapeutics, 5th edition (Baillière Tindall, London)
6. Campbell, W.C., Fisher, M.H., Stapley, E.O., Albers Schonbreg, G. and Jacob, T.A., 1983. Ivermectin: A potent new antiparasitic agent. Science, 221, 823-828
7. Costa, E. and Guidotti, A., 1979. Molecular mechanisms in the receptor action of benzodiazepines. Annual Review of Pharmacology and Toxicology, 19, 531-545
8. Cully, D.F., Vassilatis, D.K., Lin, K.K., Paress, P.S., Van der Ploeg, L.H., Schaeffer, J.M. and Arena, J.P., 1994. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature, 20 (371;6499), 707-711
9. A receptor. The Journal of Pharmacology and Experimental Therapeutics, 250, 1051-1060
10. Duce, I.R. and Scott, R.H., 1985. Action of dihydroavermectin B on insect muscle. British Journal of Pharmacology, 85, 395-401
11. Etter, A., Cully, D.F., Liu, K.K., Reiss, B., Vassilatis, D.K., Schaeffer, J.M. and Arena, J.P., 1999. Picrotoxin blockade of invertebrate glutamate-gated chloride channels: Subunit depedence and evidence for binding within the pore. Journal of Neurochemistry, 72 (1), 318-326
12. Forshaw, P.J., Lister, T. and Ray, E.D., 2000. The role of voltage-gated chloride channels in type II pyrethroid insecticide poisoning. Toxicology and Applied Pharmacology, 163 (1), 1-8
13. Hardman, J.G., Limbird, L.E. and Gilman, A.G., 2001. Goodman-Gilman's The Pharmacological Basis of Therapeutics, 9th edn, (The Macmillan Company, London and Toronto)
14. Home Office Code of Practice, 1997. The Humane Killing of Animals under Schedule 1 to the Animals (Scientific Procedures) Act 1986, (HMSO, London; ISBN 0-10-265397-6)
15. Ikeda, M., Dohi, T.and Tsujimoto, A., 1982. Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics. Anesthesiology, 58 (6), 495-499
16. Kamijima, M. and Casida, J.E., 2000. Regional modification of [(3)H]ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil and avermectin B (1a). Toxicology and Applied Pharmacology, 163 (2), 188-194
17. Karns, P.A. and Luther, D.G., 1984. A survey of adverse effects associated with ivermectin use in Louisiana horses. Journal of the American Veterinary Medical Association, 185 (7), 782-783
18. Kubova, H. and Mares, P., 1994. Effects of MK-801 (dizocilpine) and ketamine on strychnine-induced convulsions in rats: Comparison with benzodiazepines and standard anticonvulsants. Physiological Research, 43 (5), 313-320
19. Lovell, R.A., 1991. Ivermectin and piperazine toxicoses in dogs and cats. The veterinary clinics of North America. Small Animal Practice, 20 (2), 453-468
20. Ruiz-Gomez, A., Garcia-Calvo, M., Vazquez, J., Marvizon, J.C., Valdivieso, F. and Mayor, F, Jr., 1989. Thermodynamics of agonist and antagonist interaction with the strychnine-sensitive glycine receptor. Journal of Neurochemistry, 52 (6), 1775-1780
21. Saneford, E.S., Rehmtulla, A.J. and Gaylou, K.A., 1998. Ivermectin overdose and toxicosis in neonatal pigs. Parasitology, (Proc. I.P.V.S., Ch.IV), 217
22. Sawaki, K., Ohno, K., Mijamoto, K., Hirai, S., Yazaki, K. and Kawaguchi, M., 2000. Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats. Pharmacology and Toxicology, 86, 59-62
23. Schonrock, B. and Borman, J., 1993. Activation of Cl channels by avermectin in rat cultured hippocampal neurons. Naunyn-Schmiedeberg's Archives of Pharmacology, 348 (6), 628-632
24. Shan, Q., Haddrill, J. and Lynch, J. 2001. Ivermectin, an unconventional agonist of the glycine receptor chloride channel. The Journal of Biological Chemistry, 276 (16), 12556-12564 12556-12564
25. Shenoy, A.K., Miyahara, J.T., Swinyard, E.A. and Kupferberg, H.J., 1982. Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats. Epilepsia, 23 (4), 399-408
26. Tallarida, R.J. and Murray, R.B., 1987. Manual of Pharmacologic Calculations, with Computer Programs, 2nd ed. (Springer-Verlag, New York)
27. Vassilatis, D.K., Elliston, K.O., Paress, P.S., Hamelin, M., Arena, J.P., Schalffer, J.M., Van der Ploeg, L.H. and Cully, D.F., 1997. Evolutionary relationship at the ligand-gated ion channels and the avermectin sensitive glutamate gated chloride channels. Journal of Molecular Evolution, 44 (5), 501-508
28. Yokoyama, M., Benson, K.T., Arakawa, K. and Goto, H., 1992. Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. Anesthesia and Analgesia, 75 (1): 87-90