Histone methyltransferase PR-Set7 and Histone Variant H2A.Z, Induced during hepatocarcinogenesis, repress the promoter activity of the tumor marker Gene and the ras-induced colony formation activity

Journal of Health Science

Volumn 57, Issue 3, 2011, Pages 264-273

  Hashizume, Hiroshi ^a   Gomita, Urara ^a   Imagawa, Masayoshi ^a   Osada, Shigehiro ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Anchorage independent growth; Epigenetics; Hepatocarcinogenesis; Histone methyltransferase; Histone variant; Tumor marker gene

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P; HISTONE H2AZ; HISTONE METHYLTRANSFERASE; PR SET7 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN 3T3; CHEMICAL CARCINOGENESIS; COLONY FORMATION; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; GST P GENE; H2AZ GENE; LIVER CARCINOGENESIS; MALIGNANT TRANSFORMATION; MARKER GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PR SET7 GENE; PROMOTER REGION; RAT; UPREGULATION;

EID: 79958040130     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.57.264     Document Type: Article

References (52)

1. Miremadi, A., Oestergaard, M. Z., Pharoah, P. D. and Caldas, C. (2007) Cancer genetics of epigenetic genes. Hum. Mol. Genet., 16, R28-R49.
2. Portela, A. and Esteller, M. (2010) Epigenetic modifications and human disease. Nat. Biotechnol., 28, 1057-1068.
3. Lopez, J., Percharde, M., Coley, H. M., Webb, A. and Crook, T. (2009) The context and potential of epigenetics in oncology. Br. J. Cancer, 100, 571-577.
4. Kelly, T. K., De Carvalho, D. D. and Jones, P. A. (2010) Epigenetic modifications as therapeutic targets. Nat. Biotechnol., 28, 1069-1078.
5. Solt, D. and Farber, E. (1976) New principle for the analysis of chemical carcinogenesis. Nature, 263, 701-703.
6. Osada, S., Naganawa, A., Misonou, M., Tsuchiya, S., Tamba, S., Okuno, Y., Nishikawa, J., Satoh, K., Imagawa, M., Tsujimoto, G., Sugimoto, Y. and Nishihara, T. (2006) Altered gene expression of transcriptional regulatory factors in tumor markerpositive cells during chemically induced hepatocarcinogenesis. Toxicol. Lett., 167, 106-113.
7. Ohta, K., Ohigashi, M., Naganawa, A., Ikeda, H., Sakai, M., Nishikawa, J., Imagawa, M., Osada, S. and Nishihara, T. (2007) Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Biochem. J., 402, 559-566.
8. Yura, T., Hashizume, H., Suzuki, E., Imagawa, M. and Osada, S. (2010) Promotion of anchorageindependent growth by cytoplasmic and nuclear histone deacetylase 9. J. Health Sci., 56, 581-588.
9. Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M. and Ito, N. (1984) The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann, 75, 199-202.
10. Iouzalen, N., Moreau, J. and Mechali, M. (1996) H2A. ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A. Nucleic Acids Res., 24, 3947-3952.
11. Jiang, W., Guo, X. and Bhavanandan, V. P. (1998) Histone H2A. F/Z subfamily: the smallest member and the signature sequence. Biochem. Biophys. Res. Commun., 245, 613-617.
12. Barski, A., Cuddapah, S., Cui, K., Roh, T. Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I. and Zhao, K. (2007) High-resolution profiling of histone methylations in the human genome. Cell, 129, 823-837.
13. Zlatanova, J. and Thakar, A. (2008) H2A. Z: view from the top. Structure, 16, 166-179.
14. Gevry, N., Chan, H. M., Laflamme, L., Livingston, D. M. and Gaudreau, L. (2007) p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev., 21, 1869-1881.
15. Svotelis, A., Gevry, N. and Gaudreau, L. (2009) Regulation of gene expression and cellular proliferation by histone H2A.Z. Biochem. Cell Biol., 87, 179-188.
16. Couture, J. F., Collazo, E., Brunzelle, J. S. and Trievel, R. C. (2005) Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev., 19, 1455-1465.
17. Xiao, B., Jing, C., Kelly, G., Walker, P. A., Muskett, F.W., Frenkiel, T. A., Martin, S. R., Sarma, K., Reinberg, D., Gamblin, S. J. and Wilson, J. R. (2005) Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev., 19, 1444-1454.
18. Nishioka, K., Rice, J. C., Sarma, K., Erdjument-Bromage, H., Werner, J., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., Lis, J. T., Allis, C. D. and Reinberg, D. (2002) PRSet7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell, 9, 1201-1213.
19. Rice, J. C., Nishioka, K., Sarma, K., Steward, R., Reinberg, D. and Allis, C. D. (2002) Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev., 16, 2225-2230.
20. Sakaguchi, A. and Steward, R. (2007) Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster. J. Cell Biol., 176, 155-162.
21. Houston, S. I., McManus, K. J., Adams, M. M., Sims, J. K., Carpenter, P. B., Hendzel, M. J. and Rice, J. C. (2008) Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J. Biol. Chem., 283, 19478-19488.
22. Huen, M. S., Sy, S. M., van Deursen, J. M. and Chen, J. (2008) Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J. Biol. Chem., 283, 11073-11077.
23. Oda, H., Okamoto, I., Murphy, N., Chu, J., Price, S. M., Shen, M. M., Torres-Padilla, M. E., Heard, E. and Reinberg, D. (2009) Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol. Cell. Biol., 29, 2278-2295.
24. Wu, S., Wang, W., Kong, X., Congdon, L. M., Yokomori, K., Kirschner, M. W. and Rice, J. C. (2010) Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev., 24, 2531-2542.
25. Fang, J., Feng, Q., Ketel, C. S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J. A. and Zhang, Y. (2002) Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr. Biol., 12, 1086-1099.
26. Kohlmaier, A., Savarese, F., Lachner, M., Martens, J., Jenuwein, T. and Wutz, A. (2004) A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol., 2, 991-1003.
27. Talasz, H., Lindner, H. H., Sarg, B. and Helliger, W. (2005) Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. J. Biol. Chem., 280, 38814-38822.
28. Fujioka, H., Kaibuchi, K., Kishi, K., Yamamoto, T., Kawamura, M., Sakoda, T., Mizuno, T. and Takai, Y. (1992) Transforming and c-fos promoter/enhancerstimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins. J. Biol. Chem., 267, 926-930.
29. Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K. and Hayashi, H. (2005) TRB3, a novel ER stressinducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J., 24, 1243-1255.
30. Osada, S., Takano, K., Nishihara, T., Suzuki, T., Muramatsu, M. and Imagawa, M. (1995) CCAAT/enhancer-binding proteins alpha and beta interact with the silencer element in the promoter of glutathione S-transferase P gene during hepatocarcinogenesis. J. Biol. Chem., 270, 31288-31293.
31. Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
32. Sakai, M. and Muramatsu, M. (2007) Regulation of glutathione transferase P: a tumor marker of hepatocarcinogenesis. Biochem. Biophys. Res. Commun., 357, 575-578.
33. Sakai, M., Okuda, A. and Muramatsu, M. (1988) Multiple regulatory elements and phorbol 12-Otetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene. Proc. Natl. Acad. Sci. U.S.A., 85, 9456-9460.
34. Morimura, S., Suzuki, T., Hochi, S., Yuki, A., Nomura, K., Kitagawa, T., Nagatsu, I., Imagawa, M. and Muramatsu, M. (1993) Trans-activation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat. Proc. Natl. Acad. Sci. U.S.A., 90, 2065-2068.
35. Imagawa, M., Osada, S., Okuda, A. and Muramatsu, M. (1991) Silencer binding proteins function on multiple cis-elements in the glutathione transferase P gene. Nucleic Acids Res., 19, 5-10.
36. Imagawa, M., Osada, S., Koyama, Y., Suzuki, T., Hirom, P. C., Diccianni, M. B., Morimura, S. and Muramatsu, M. (1991) SF-B that binds to a negative element in glutathione transferase P gene is similar or identical to trans-activator LAP/IL6-DBP. Biochem. Biophys. Res. Commun., 179, 293-300.
37. Osada, S., Daimon, S., Ikeda, T., Nishihara, T., Yano, K., Yamasaki, M. and Imagawa, M. (1997) Nuclear factor 1 family proteins bind to the silencer element in the rat glutathione transferase P gene. J. Biochem., 121, 355-363.
38. Kobor, M. S., Venkatasubrahmanyam, S., Meneghini, M. D., Gin, J. W., Jennings, J. L., Link, A. J., Madhani, H. D. and Rine, J. (2004) A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A. Z into euchromatin. PLoS. Biol., 2, 587-599.
39. Krogan, N. J., Keogh, M. C., Datta, N., Sawa, C., Ryan, O. W., Ding, H., Haw, R. A., Pootoolal, J., Tong, A., Canadien, V., Richards, D. P., Wu, X., Emili, A., Hughes, T. R., Buratowski, S. and Greenblatt, J. F. (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol. Cell, 12, 1565-1576.
40. Mizuguchi, G., Shen, X., Landry, J., Wu, W. H., Sen, S. and Wu, C. (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science, 303, 343-348.
41. Luk, E., Ranjan, A., Fitzgerald, P. C., Mizuguchi, G., Huang, Y., Wei, D. and Wu, C. (2010) Stepwise histone replacement by SWR1 requires dual activation with histone H2A. Z and canonical nucleosome. Cell, 143, 725-736.
42. Ikeda, H., Nishi, S. and Sakai, M. (2004) Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. Biochem. J., 380, 515-521.
43. Congdon, L. M., Houston, S. I., Veerappan, C. S., Spektor, T. M. and Rice, J. C. (2010) PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression. J. Cell. Biochem., 110, 609-619.
44. Karnoub, A. E. and Weinberg, R. A. (2008) Ras oncogenes: split personalities. Nat. Rev. Mol. Cell Biol., 9, 517-531.
45. Lau, K. S. and Haigis, K. M. (2009) Nonredundancy within the RAS oncogene family: insights into mutational disparities in cancer. Mol. Cells, 28, 315-320.
46. Dunican, D. S., McWilliam, P., Tighe, O., Parle-McDermott, A. and Croke, D. T. (2002) Gene expression differences between themicrosatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by highdensity cDNA array hybridization. Oncogene, 21, 3253-3257.
47. Hua, S., Kallen, C. B., Dhar, R., Baquero, M. T., Mason, C. E., Russell, B. A., Shah, P. K., Liu, J., Khramtsov, A., Tretiakova, M. S., Krausz, T. N., Olopade, O. I., Rimm, D. L. and White, K. P. (2008) Genomic analysis of estrogen cascade reveals histone variant H2A. Z associated with breast cancer progression. Mol. Syst. Biol., 4, 188.
48. Barzily-Rokni, M., Friedman, N., Ron-Bigger, S., Isaac, S., Michlin, D. and Eden, A. (2011) Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A). Nucleic Acids Res., 39, 1326-1335.
49. Kapoor, A., Goldberg, M. S., Cumberland, L. K., Ratnakumar, K., Segura, M. F., Emanuel, P. O., Menendez, S., Vardabasso, C., Leroy, G., Vidal, C. I., Polsky, D., Osman, I., Garcia, B. A., Hernando, E. and Bernstein, E. (2010) The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature, 468, 1105-1109.
50. Fraga, M. F., Ballestar, E., Villar-Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C., Ropero, S., Petrie, K., Iyer, N. G., Perez-Rosado, A., Calvo, E., Lopez, J. A., Cano, A., Calasanz, M. J., Colomer, D., Piris, M. A., Ahn, N., Imhof, A., Caldas, C., Jenuwein, T. and Esteller, M. (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet., 37, 391-400.
51. Pogribny, I. P., Ross, S. A., Tryndyak, V. P., Pogribna, M., Poirier, L. A. and Karpinets, T. V. (2006) Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis, 27, 1180-1186.
52. Tryndyak, V. P., Kovalchuk, O. and Pogribny, I. P. (2006) Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol. Ther., 5, 65-70.