Insulin resistance: A potential marker and risk factor for active tuberculosis?

Medical Hypotheses

Volumn 77, Issue 1, 2011, Pages 66-68

  Mao, Fengfeng ^a   Chen, Tao ^b   Zhao, Yong ^a   Zhang, Caiqin ^a   Bai, Bing ^a   Zhao, Shanmin ^a   Xu, Zhikai ^a   Shi, Changhong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ARTICLE; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE PREDISPOSITION; HUMAN; INFECTION RISK; INSULIN RESISTANCE; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PHAGOCYTOSIS; RISK FACTOR; SIGNAL TRANSDUCTION; TUBERCULOSIS;

HUMANS; INSULIN; INSULIN RESISTANCE; SIGNAL TRANSDUCTION; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79958035835     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.03.025     Document Type: Article

References (35)

1. WHO, Global tuberculosis control: epidemiology, strategy, financing: WHO report 2009. WHO/HTM/TB/2009.411 Geneva: WHO. Available from: (2009). http://www.who.int/tb/publications/global_report/2009/update/tbu_9.pdf.
2. Jeon C.Y., Murray M.B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med 2008, 5:e152.
3. De Cock K.M., Soro B., Coulibaly I.M., SB L. HIV tuberculosis and HIV infection in Sub-Saharan Africa. JAMA 1992, 268:1581-1587.
4. Venkata R.K., Kumar S., Krishna R.P., Kumar S.B., Padmanabhan S., Kumar S. Tuberculosis in chronic kidney disease. Clin Nephrol 2007, 67:217-220.
5. Feld R., Bodey G.P., Groschel D. Mycobacteriosis in patients with malignant disease. Arch Intern Med 1976, 136:67-70.
6. Tiruviluamala P., Reichman L.B. Tuberculosis. Annu Rev Public Health 2002, 23:403-426.
7. Ghezzo F., Garbarino G., Ioverno L. Insulin modulates human mononuclear adherent cell fibrinolytic and phagocytic activities. Scand J Haematol 1983, 30:379-383.
8. Bar R.S., Kahn C.R., Koren H.S. Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages. Nature 1977, 265:632-635.
9. Plotkin B.J., Paulson D., Chelich A., et al. Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): susceptibility to Candida albicans infection and leucocyte function. J Med Microbiol 1996, 44:277-283.
10. Fan W., Morinaga H., Kim J.J., et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. The EMBO J 2010, 29:4223-4236.
11. Ginsberg H.N. Insulin resistance and cardiovascular disease. J Clin Invest 2000, 106:453-458.
12. Natali A., Ferrannini E. Hypertension, insulin resistance, and the metabolic syndrome. Endocrinol Metab Clin North Am 2004, 33:417-429.
13. Park K.H., Kim J.Y., Ahn C.W., Song Y.D., Lim S.K., Lee H.C. Polycystic ovarian syndrome (PCOS) and insulin resistance. Int J Gynaecol Obstet 2001, 74:261-267.
14. Reaven G.M. Banting lecture role of insulin resistance in human disease. Diabetes 1988, 37(1988):1595-1607.
15. Kahn B.B., Flier J.S. Obesity and insulin resistance. J Clin Invest 2000, 106:473-481.
16. Erol A. Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation. Med Hypotheses 2010, 74:1038-1043.
17. Erol A. Systemic DNA damage response and metabolic syndrome as a premalignant state. Curr Mol Med 2010, 10:321-334.
18. Erol A. Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair apoptosis or senescence in response to damaging signals. Cell Signal 2010, Epub ahead of print.
19. Broxmeyer L. Diabetes mellitus tuberculosis and the mycobacteria: Two millenia of enigma. Med Hypotheses 2005, 65:433-439.
20. Erol A. Visceral adipose tissue specific persistence of Mycobacterium tuberculosis may be reason for the metabolic syndrome. Med Hypotheses 2008, 71:222-228.
21. Korbel D.S., Schneider B.E., Schaible U.E. Innate immunity in tuberculosis: myths and truth. Microbes Infect 2008, 10:995-1004.
22. Pfaffenberg R. The significance of phagocytosis of Mycobacteria tuberculosis during the course of tuberculosis. Z Tuberk 1955, 105:275-285.
23. Gutierrez M.G., Master S.S., Singh S.B., Taylor G.A., Colombo M.I., Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119:753-766.
24. Keane J., Balcewicz-Sablinska M.K., Remold H.G., et al. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun 1997, 65:298-304.
25. Reid A., Scano F., Getahun H., et al. Towards universal access to HIV prevention, treatment, care, and support: the role of tuberculosis/HIV collaboration. Lancet Infect Dis 2006, 6:483-495.
26. Pieters J. Mycobacterium tuberculosis and the macrophage: maintaining a balance. Cell Host Microbe 2008, 3:399-407.
27. Berrington W.R., Hawn T.R. Mycobacterium tuberculosis macrophages and the innate immune response: does common variation matter?. Immunol Rev 2007, 219:167-186.
28. Iida K.T., Suzuki H., Sone H., et al. via phosphatidylinositol-3-kinase-dependent pathway. Arterioscler Thromb Vasc Biol 2002, 22:380-386.
29. Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006, 7:85-96.
30. Liang C.P., Han S., Okamoto H., et al. Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest 2004, 113:764-773.
31. Rosa L.F., Cury Y., Curi R., et al. Effects of insulin glucocorticoids thyroid hormones on the activities of key enzymes of glycolysis the pentose-phosphate pathway and the Krebs cycle in rat macrophages. J Endocrinol 1992, 135:213-219.
32. Fortuno A., San J.G., Moreno M.U., Beloqui O., Diez J., Zalba G. Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Diabetes 2006, 55:209-215.
33. Lima A.O., Queiroz M.Bräscher H.M. Effect of insulin on immunological phagocytosis by macrophages. Experientia 1979, 35:119-120.
34. Hartman M.E., O'Connor J.C., Godbout J.P., Minor K.D., Mazzocco V.R., Freund G.G. Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus. J Biol Chem 2004, 279:28045-28050.
35. Han S., Liang C.P., DeVries-Seimon T., et al. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 2006, 3:257-266.