Effects of aerobic exercise on premenopausal sex hormone levels: Results of the WISER study, a randomized clinical trial in healthy, sedentary, eumenorrheic women

Cancer Epidemiology Biomarkers and Prevention

Volumn 20, Issue 6, 2011, Pages 1098-1106

  Smith, Alma J ^a   Phipps, William R ^b   Arikawa, Andrea Y ^a   O'Dougherty, Maureen ^a   Kaufman, Beth ^a   Thomas, William ^b   Schmitz, Kathryn H ^c   Kurzer, Mindy S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRONE SULFATE; PROGESTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AEROBIC EXERCISE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DIET RESTRICTION; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLICULAR PHASE; HUMAN; LEAN BODY WEIGHT; LUTEAL PHASE; NORMAL HUMAN; PREMENOPAUSE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEDENTARY LIFESTYLE; TESTOSTERONE BLOOD LEVEL; WEIGHT REDUCTION;

ADULT; BODY COMPOSITION; CASE-CONTROL STUDIES; EXERCISE; FEMALE; GONADAL STEROID HORMONES; HUMANS; OLIGOMENORRHEA; PREMENOPAUSE; SEDENTARY LIFESTYLE; SEX HORMONE-BINDING GLOBULIN; WOMEN'S HEALTH;

EID: 79958032944     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-10-1219     Document Type: Article

References (43)

1. American Cancer Society. Cancer facts & figures 2009. Atlanta, GA: American Cancer Society; 2009.
2. Armstrong K, Eisen A, Weber B. Assessing the risk of breast cancer. N Engl J Med 2000;342:564-71. (Pubitemid 30117898)
3. Monninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW, et al. Physical activity and breast cancer: a systematic review. Epidemiology 2007;18:137-57. (Pubitemid 46005918)
4. Gupta M, McDougal A, Safe S. Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. J Steroid Biochem Mol Biol 1998;67:413-9. (Pubitemid 29049414)
5. Suto A, Bradlow HL, Wong GY, Osborne MP, Telang NT. Experimental down-regulation of intermediate biomarkers of carcinogenesis inmouse mammary epithelial cells. Breast Cancer Res Treat 1993;27:193-202. (Pubitemid 23355306)
6. Lange CA, Yee D. Progesterone and breast cancer. Womens Health (Lond Engl) 2008;4:151-62. (Pubitemid 351513635)
7. Knochenhauer ES, Boots LR, Potter HD, Azziz R. Differential binding of estradiol and testosterone to SHBG. Relation to circulating estradiol levels. J Reprod Med 1998;43:665-70. (Pubitemid 28402353)
8. Fortunati N, Catalano MG. Sex hormone-binding globulin (SHBG) and estradiol cross-talk in breast cancer cells. Horm Metab Res 2006;38:236-40. (Pubitemid 43845215)
9. Key T, Appleby P, Barnes I, Reeves G, Endogenous H, Breast Cancer Collaborative G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-16. (Pubitemid 34498648)
10. Wang B, Mi M, Wang J, Wei N, Zhang Q, Zhu J, et al. Does the increase of endogenous steroid hormone levels also affect breast cancer risk in Chinese women? A case-control study in Chongqing, China. Int J Cancer 2009;124:1892-9.
11. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, et al. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 2006;98:1406-15. (Pubitemid 44530717)
12. Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2005;97:755-65. (Pubitemid 40879595)
13. Sturgeon SR, Potischman N, Malone KE, Dorgan JF, Daling J, Schairer C, et al. Serum levels of sex hormones and breast cancer risk in premenopausal women: a case-control study (USA). Cancer Causes Control 2004;15:45-53. (Pubitemid 38339971)
14. Micheli A, Muti P, Secreto G, Krogh V, Meneghini E, Venturelli E, et al. Endogenous sex hormones and subsequent breast cancer in premenopausal women. Int J Cancer 2004;112:312-8. (Pubitemid 39244371)
15. Yu H, Shu XO, Shi R, Dai Q, Jin F, Gao YT, et al. Plasma sex steroid hormones and breast cancer risk in Chinese women. Int J Cancer 2003;105:92-7. (Pubitemid 36418491)
16. Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE. A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiol Biomarkers Prev 2000;9:575-9. (Pubitemid 30396179)
17. Thomas HV, Key TJ, Allen DS, Moore JW, Dowsett M, Fentiman IS, et al. A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey. Br J Cancer 1997;75:1075-9. (Pubitemid 27122629)
18. Rosenberg CR, Pasternack BS, Shore RE, Koenig KL, Toniolo PG. Premenopausal estradiol levels and the risk of breast cancer: a new method of controlling for day of the menstrual cycle. Am J Epidemiol 1994;140:518-25. (Pubitemid 24285934)
19. Helzlsouer KJ, Alberg AJ, Bush TL, Longcope C, Gordon GB, Comstock GW. A prospective study of endogenous hormones and breast cancer. Cancer Detect Prev 1994;18:79-85. (Pubitemid 2077549)
20. Secreto G, Toniolo P, Pisani P, Recchione C, Cavalleri A, Fariselli G, et al. Androgens and breast cancer in premenopausal women. Cancer Res 1989;49:471-6. (Pubitemid 19049545)
21. Wysowski DK, Comstock GW, Helsing KJ, Lau HL. Sex hormone levels in serum in relation to the development of breast cancer. Am J Epidemiol 1987;125:791-9. (Pubitemid 17066478)
22. Friedenreich CM, Cust AE. Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 2008;42:636-47.
23. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002;132S uppl:3456S-64S.
24. Williams NI, Reed JL, Leidy HJ, Legro RS, De Souza MJ. Estrogen and progesterone exposure is reduced in response to energy deficiency in women aged 25-40 years. Hum Reprod 2010;25:2328-39.
25. Arikawa AY, O'Dougherty M, Kaufman B, Smith AJ, Thomas W, Warren M, et al. Women In Steady Exercise Research (WISER): study design and methods. Contemp Clin Trials 2010;31:457-65.
26. Medicine ACoS. Guidelines for exercise testing and prescription. 6th ed. Philadelphia, PA: LippincottWilliams & Wilkins; 2000.
27. Kriska AM, Knowler WC, LaPorte RE, Drash AL, Wing RR, Blair SN, et al. Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians. Diabetes Care 1990;13:401-11. (Pubitemid 20109476)
28. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000;32 Suppl:S498-504.
29. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-72. (Pubitemid 30645223)
30. Mazer NA. A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations. Steroids 2009;74:512-9.
31. Arikawa AY, O'Dougherty M, Schmitz KH. Adherence to a strength training intervention in adult women. J Phys Act Health 2011;8:111-8.
32. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007;39:1423-34. (Pubitemid 47344026)
33. Bjornerem A, Straume B, Midtby M, Fønnebø V, Sundsfjord J, Svartberg J, et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromso Study. J Clin Endocrinol Metab 2004;89:6039-47. (Pubitemid 39628412)
34. Tworoger SS, Missmer SA, Eliassen AH, Barbieri RL, Dowsett M, Hankinson SE. Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Cancer Causes Control 2007;18:743-52. (Pubitemid 46988242)
35. Schmitz KH, Lin H, Sammel MD, Gracia CR, Nelson DB, Kapoor S, et al. Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study. Cancer Epidemiol Biomarkers Prev 2007;16:2042-7. (Pubitemid 47621178)
36. Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ. Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control 2001;12:47-59. (Pubitemid 32125900)
37. Nagata C, Kaneda N, Kabuto M, Shimizu H. Factors associated with serum levels of estradiol and sex hormone-binding globulin among premenopausal Japanese women. Environ Health Perspect 1997;105:994-7. (Pubitemid 27503633)
38. Jasienska G, Ziomkiewicz A, Thune I, Lipson SF, Ellison PT. Habitual physical activity and estradiol levels in women of reproductive age. Eur J Cancer Prev 2006;15:439-45. (Pubitemid 44252915)
39. Rogol AD, Weltman A, Weltman JY, Seip RL, Snead DB, Levine S, et al. Durability of the reproductive axis in eumenorrheic women during 1 yr of endurance training. J Appl Physiol 1992;72:1571-80.
40. Schmitz KH, Warren M, Rundle AG, Williams NI, Gross MD, Kurzer MS. Exercise effect on oxidative stress is independent of change in estrogen metabolism. Cancer Epidemiol Biomarkers Prev 2008;17:220-3. (Pubitemid 351196294)
41. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer 2008;8:205-11. (Pubitemid 351301840)
42. Grodin JM, Siiteri PK, MacDonald PC. Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 1973;36:207-14.
43. Judd HL, Shamonki IM, Frumar AM, Lagasse LD. Origin of serum estradiol in postmenopausal women. Obstet Gynecol 1982;59:680-6. (Pubitemid 12107424)