Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors

IEEE Transactions on Medical Imaging

Volumn 30, Issue 6, 2011, Pages 1265-1273

  Stuker, Florian ^a   Baltes, Christof ^a   Dikaiou, Katerina ^a   Vats, Divya ^a   Carrara, Lucio ^b   Charbon, Edoardo ^b   Ripoll, Jorge ^c   Rudin, Markus ^a,d  

^a ETH ZURICH   (Switzerland)

^b EPFL   (Switzerland)

^c INSTITUTE OF ELECTRONIC STRUCTURE AND LASER   (Greece)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Biomedical imaging; magnetic resonance imaging (MRI); optical imaging; optical tomography

Indexed keywords

BEAM DESIGN; BIOMEDICAL IMAGING; COLON CANCER; DIFFUSE LIGHT; DYE CONCENTRATION; FLUORESCENCE EXCITATION; FLUORESCENCE IMAGING; FLUORESCENCE MOLECULAR TOMOGRAPHY; FLUORESCENCE TOMOGRAPHY; GEOMETRICAL CONSTRAINTS; HIGH QUALITY; HIGH SENSITIVITY; IN-VITRO; IN-VIVO; INTEGRATED SYSTEMS; LIVING ORGANISMS; MOLECULAR PROCESS; NON-CONTACT; OPTICAL IMAGING; PHOTON DETECTION; PROTEASE ACTIVITIES; SINGLE PHOTON AVALANCHE DIODE; SINGLE-PHOTON AVALANCHE DIODE ARRAYS; SMALL ANIMAL IMAGING; SPATIAL ACCURACY; TOMOGRAPHIC INFORMATION; TUMOR MORPHOLOGY;

ANIMALS; AVALANCHE DIODES; DETECTORS; FLUORESCENCE; INTEGRATED OPTICS; LASER EXCITATION; LIGHT PROPAGATION; MEDICAL IMAGING; OPTICAL CORRELATION; OPTICAL FIBERS; OPTICAL TOMOGRAPHY; PARTICLE BEAMS; PHOTONS; RESONANCE; TISSUE;

MAGNETIC RESONANCE IMAGING;

DIAGNOSTIC AGENT;

ANIMAL; ANIMAL DISEASE; ARTICLE; ELECTRONICS; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; FLUORESCENCE MICROSCOPY; IMAGE SUBTRACTION; INSTRUMENTATION; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL TOMOGRAPHY; PHOTOMETRY; PHOTON; RAT; REPRODUCIBILITY; SEMICONDUCTOR; SENSITIVITY AND SPECIFICITY; TRANSDUCER;

ANIMALS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; MAGNETIC RESONANCE IMAGING; MICE; MICROSCOPY, FLUORESCENCE; MINIATURIZATION; PHOTOMETRY; PHOTONS; RATS; REPRODUCIBILITY OF RESULTS; SEMICONDUCTORS; SENSITIVITY AND SPECIFICITY; SUBTRACTION TECHNIQUE; TOMOGRAPHY, OPTICAL; TRANSDUCERS;

EID: 79958004908     PISSN: 02780062     EISSN: None     Source Type: Journal    
DOI: 10.1109/TMI.2011.2112669     Document Type: Article

References (29)

1. D.W.Townsend, J. P. J.Carney, J. T. Yap, andN.Hall, "PET/CTtoday and tomorrow," J. Nucl. Med., vol. 45, no. 1, pp. 4S-14S, Jan. 2004.
2. M. S. Judenhofer, C. C. Catana, B.K. Swann, S. B. Siegel,W.-I. Jung, R. E. Nutt, S. R. Cherry, C. D. Claussen, and B. J. Pichler, "PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet," Radiology, vol. 224, no. 3, pp. 807-814, Sep. 2007. (Pubitemid 47292092)
3. M. Niedre and V. Ntziachristos, "Elucidating structure and function in vivo with hybrid fluorescence and magnetic resonance imaging," in Proc. IEEE, Mar. 2008, vol. 96, no. 3, pp. 382-396.
4. M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, "Combined magnetic resonance and bioluminescence imaging of live mice," J. Biomed. Opt., vol. 12, no. 3, p. 034018, May/Jun. 2007.
5. H. Xu, R. Springet, H. Dehghani, B. W. Pogue, K. D. Paulsen, and J. F. Dunn, "Magentic-resonance-imaging-coupled broadband near-infrared tomography system for small animal brain studies," Appl. Opt., vol. 44, no. 11, pp. 2177-2188, Apr. 2005. (Pubitemid 40567090)
6. G.Gulsen, O. Birgul,M. B.Unlu, R. Shafiiha, and O. Nalcioglu, "Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals," Technol. Cancer Res. Treatment, vol. 5, no. 4, pp. 351-363, Aug. 2006. (Pubitemid 44313706)
7. A. M. Siegel, J. B. Mandeville, and D. A. Boas, "Temporal comparison of functional brain imaging with optical tomography and fMRI during rat forepaw stimulation," Phys. Med. Biol., vol. 48, no. 10, pp. 1391-1403, 2003. (Pubitemid 36700472)
8. S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, "Magnetic resonance-coupled tomography scanner formolecular imaging of tissue," Rev. Sci. Instrum., vol. 79, no. 6, p. 064302, 2008.
9. B. J. Pichler, M. S. Judenhofer, C. Catana, J. H. Walton, M. Kneilling, R.E.Nutt, S. B. Siegel,C.D.Claussen, andS. R. Cherry, "Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI," J. Nucl. Med., vol. 47, pp. 639-647, 2006. (Pubitemid 46768465)
10. E. Grigoriev, A. Akindinov, M. Breitenmoser, S. Buono, E. Charbon, C. Niclass, I. Desforges, and R. Rocca, "Silicon photomultipliers and their bio-medical applications," Nucl. Instrum. Methods Phys. Res. A, vol. 571, pp. 130-133, 2007. (Pubitemid 46136584)
11. J. Ripoll, R. B. Schulz, and V. Ntziachristos, "Free-space propagation of diffuse light: Theory and experiments," Phys. Rev. Lett., vol. 91, no. 10, p. 103901, Sep. 2003.
12. A. Martin, J.Aguirre,A. Sarasa-Renedo,D. Tsoukatou, A. Garofalakis, H. Meyer, J. Ripoll, and A. M. Planas, "Imaging changes in lymphoid organs in vivo after brain ischemia with three-dimensional fluorescence molecular tomography in transgenic mice expressing green fluorescent protein in t lymphocytes," Molecular Imag., vol. 7, no. 4, pp. 1-11, Jul./Aug. 2008.
13. A. Sarasa-Renedo, R. Favicchio, U. Birk, G. Zacharakis, C.Malamaki, and J. Ripoll, "Source intensity profile in noncontact optical tomography," Opt. Lett., vol. 35, no. 1, pp. 34-36, Jan. 2010.
14. L. Carrara, C. Niclass, N. Scheidegger, H. Shea, and E. Charbon, "A gamma, X-ray and high energy proton radiation-tolerant CIS for space applications," in IEEE Solid-State Circuits Conf., Feb. 2009, p. 40.
15. C. Niclass, A. Rochas, A. Besse, and E. Charbon, "Design and characterization of a cmos 3-Dimage sensor based on single photon avalanche diodes," IEEE J. Solid-State Circuits, vol. 40, no. 9, pp. 1847-1854, Sep. 2005. (Pubitemid 41352162)
16. M. Hintersteiner, A. Enz, P. Frey, A.-L. Jaton, W. Kinzy, R. Kneuer, U. Neumann, M. Rudin, M. Staufenbiel, M. Stoeckli, K.-H. Wiederhold, and H.-U. Gremlich, "In vivo detection of amyloid- deposits by near-infrared imaging using an oxazine-derivative probe," Nature Biotechnol., vol. 23, no. 5, pp. 577-583, May 2005. (Pubitemid 41724896)
17. V. Ntziachristos and R. Weissleder, "Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized born approximation," Opt. Lett., vol. 26, no. 12, pp. 893-895, Jun. 2001. (Pubitemid 33693607)
18. J. Ripoll and V. Ntziachristos, "Imaging scattering media from a distance: theory and applications of noncontact optical tomography," Modern Phys. Lett. B, vol. 18, pp. 1403-1431, May 2004. (Pubitemid 41103461)
19. A. C. Kak and M. Slaney, Principles of Computerized Tomographic Imaging. Philadelphia, PA: SIAM, 2001.
20. J. Ripoll and V. Ntziachristos, "From finite to infinite volumes: Removal of boundaries in diffuse wave imaging," Phys. Rev. Lett., vol. 96, p. 173903, May 2006.
21. M. M. Mohamed and B. F. Sloane, "Cystein cathepsins: Multifunctional enzymes in cancer," Nature Rev. Cancer, vol. 6, pp. 764-775, 2006. (Pubitemid 44450465)
22. V. Ntziachristos, C.-H. Tung, C. Bremer, and R.Weissleder, "Fluorescence molecular tomography resolves protease activity in vivo," Nature Med., vol. 8, no. 7, pp. 757-760, Jul. 2002. (Pubitemid 34778731)
23. U. Mahmood, C.-H. Tung, A. Bogdanov, and R.Weissleder, "Near-infrared optical imaging of protease activity for tumor detection," Radiology, vol. 213, pp. 866-870, 1999.
24. C. Knoess, S. Siegel, A. Smith, and D. Newport, "Performance evaluation of the micropet r4 pet scanner for rodents," Eur. J. Nucl. Med. Molecular Imag., vol. 30, no. 5, pp. 737-747, 2003. (Pubitemid 36612958)
25. Y. C. Tai, A. Chatziioannou, S. Siegel, J. Young, D. Newport, R. E. Nutt, and S. R. Cherry, "Performance evaluation of the microPET P4: A PET system dedicated to animal imaging," Phys. Med. Biol., vol. 46, no. 7, pp. 1845-1862, 2001. (Pubitemid 32677543)
26. C.-H. Tung, U. Mahmood, S. Bredow, and R. Weissleder, "In vivo imaging of proteolytic enzyme activity using a novel molecular reporter," Cancer Res., vol. 60, pp. 4953-4958, Sep. 2000.
27. M. Rudin, P. M. J. McSheehy, P. R. Allegrini, M. Rausch, D. Baumann, M. Becquet, K. Brecht, J. Brueggen, S. Ferretti, F. Schaeffer, C. Schnella, and J. Wood, "PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo," NMR Biomed., vol. 18, no. 5, pp. 308-321, Aug. 2005. (Pubitemid 41158696)
28. P. E. Kinahan, B. H. Hasegawa, and T. Beyer, "X-ray-based attenuation correction for positron emission tomography/computed tomography scanners," Seminars Nucl. Med., vol. 33, no. 3, pp. 166-179, Jul. 2003. (Pubitemid 36859496)
29. D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, "Data specific spatially varying regularization for multimodal fluorescence molecular tomography," IEEE Trans. Med. Imag., vol. 29, no. 2, pp. 365-374, Feb. 2010.