Early and post-weaning malnutrition impairs alpha-MSH expression in the hypothalamus: A possible link to long-term overweight

Nutritional Neuroscience

Volumn 14, Issue 2, 2011, Pages 72-79

  del Carmen Miñana Solis, María ^a   Escobar, Carolina ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Appetite programming; Energy balance; Hypothalamus; Malnutrition; Metabolic programming

Indexed keywords

ALPHA INTERMEDIN; GLUCOSE; NEUROPEPTIDE Y; OREXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET THERAPY; DISEASE ASSOCIATION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MALNUTRITION; NONHUMAN; OBESITY; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS DORSOMEDIAL NUCLEUS; WEIGHT GAIN; WISTAR RAT;

ALPHA-MSH; ANIMALS; FEMALE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTATION; MALE; MALNUTRITION; MEDIODORSAL THALAMIC NUCLEUS; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; OVERWEIGHT; RATS; RATS, WISTAR; WEANING;

RATTUS; RATTUS NORVEGICUS;

EID: 79958004769     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830511Y.0000000003     Document Type: Article

References (40)

1. Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Schroeder-Tanka JM, et al. Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. Heart 2000;84:595-8.
2. Remacle C, Bieswal F, Reusens B. Programming of obesity and cardiovascular disease. Int J Obes Relat Metab Disord 2004;28 Suppl. 3: S46-S53.
3. Yajnik CS, Deshmukh US. Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord 2008; 9: 203-11.
4. Fernandez-Twinn DS, Ozanne SE, Ekizoglou S, Doherty C, James L, Gusterson B, et al. The maternal endocrine environment in the low-protein model of intra-uterine growth restriction. Br J Nutr 2003;90:815-22.
5. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 2005;85:571-633.
6. Miñana-Solis MC, Escobar C. Post-weaning protein malnutrition in the rat produces short and long term metabolic impairment, in contrast to earlier and later periods. Int J Biol Sci 2008; 4:422-32.
7. Miñana-Solis MC, Angeles-Castellanos M, Buijs R, Escobar C. Altered FOS immunoreactivity in the hypothalamus after glucose administration in pre and post-weaning malnourished rats. Nutr Neurosci 2010;13:152-60.
8. Plagemann A, Harder T, Rake A, Melchior K, Rohde W, Dörner G. Hypothalamic nuclei are malformed in weaning offspring of low protein malnourished rat dams. J Nutr 2000;130:2582-9.
9. Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, et al. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus pro-opiomelanocortin neurons in neonatal male rat pups. Endocrinology 2008;149:470-5.
10. Gao Q, Horvarth TL. Neuronal control of energy homeostasis. FEBS Lett 2008;582:132-41.
11. Terroni PL, Anthony FW, Hanson MA, Cagampang FR. Expression of agouti-related peptide, neuropeptide Y, pro-opio-melanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted diet. Brain Res Mol Brain Res 2005;140:111-5.
12. Plagemann A, Waas T, Harder T, Rittel F, Ziska T, Rohde W. Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats. Neuropeptides 2000;34:1-6.
13. Arora S, Anubhuti. Role of neuropeptides in appetite regulation and obesity - a review. Neuropeptides 2006;40:375-401
14. Marty N, Dallaporta M, Thorens B. Brain glucose sensing, counterregulation, and energy homeostasis. Physiology 2007; 22:241-51.
15. Miñana-Solis MC, Escobar C. Increased susceptibility to metabolic alterations in young adult females exposed to early malnutrition. Int J Biol Sci 2006;3:12-9.
16. Díaz-Cintra S, González-Maciel A, Morales MA, Aguilar A, Cintra L, Prado-Alcalá RA. Protein malnutrition differentially alters the number of glutamic acid decarboxylase-67 inter-neurons in dentate gyrus and CA1-3 subfields of the dorsal hippocampus. Exp Neurol 2007;208:47-53.
17. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press; 1998.
18. Cintra L, Galván A, Díaz-Cintra S, Escobar C. Protein malnutrition on suprachiasmatic nucleus cells in rats of three ages. Bol Estud Med Biol 1994;42:11-9.
19. Resnick O, Morgane PJ, Hasson R, Miller M. Overt and hidden forms of chronic malnutrition in the rat and their relevance to man. Neurosci Biobehav Rev 1982;6:55-75.
20. Bieswal F, Ahn MT, Reusens B, Holvoet P, Raes M, Rees WD, et al. The importance of catch-up growth after early malnutrition for the programming of obesity in male rat. Obesity 2006;14: 1330-1343.
21. Desai M, Byrne CD, Meeran K, Desai M, Byrne CD, Meeran K, et al. Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced protein diet. Am J Physiol 1997; 273:G899-904.
22. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetología 1992; 35:595-601.
23. Petry CJ, Ozanne SE, Hales CN. Programming of intermediary metabolism. Mol Cell Endocrinol 2001;185:81-91.
24. Dollet JM, Beck B, Villaume C, Max JP, Debry G. Progressive adaptation of the endocrine pancreas during long-term protein deficiency in rats: effects on blood glucose homeostasis and on pancreatic insulin, glucagon and somatostatin concentrations. J Nutr 1985;115:1581-88.
25. Gosby AK, Maloney CA, Phuyal JL, Denyer GS, Bryson JM, Caterson ID. Maternal protein restriction increases hepatic glycogen storage in young rats. Pediatr Res 2003;54: 413-18.
26. Orozco-Sólis R, Lopes de Souza S, Barbosa Matos RJ, Grit I, Le Bloch J, Nguyen P. Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding. Physiol Behav 2008;96:481-92.
27. Thompson NM, Norman AM, Donkin SS, Shankar RR, Vickers MH, Miles JL, et al. Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes. Endocrinology 2007;148:2345-54.
28. Snoeck A, Remacle C, Reusens B, Hoet JJ. Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biol Neonate 1990;57:107-18.
29. Dahri S, Snoeck A, Reusens-Billen B, Remacle C, Hoet JJ. Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 1991;40:115-20.
30. Hales CN, Desai M, Ozanne SE, Crowther NJ. Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochem Soc Trans 1996;24:341-50.
31. Bernardis LL, Bellinger LL. The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 1996;20: 189-287.
32. Orsini JC, Armstrong DL, Wayner MJ. Responses of lateral hypothalamic neurons recorded in vitro to moderate changes in glucose concentration. Brain Res Bull 1992;29:503-5.
33. Cai XJ, Widdowson PS, Harrold J, Wilson S, Buckingham RE, Arch JR, et al. Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 1999;48:2132-7.
34. Grove KL, Smith MS. Ontogeny of the hypothalamic neuropep-tide Y system. Physiol Behav 2003;79:47-63.
35. Breton C, Lukaszewski MA, Risold PY, Enache M, Guillemot J, Rivière G, et al. Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring. Am J Physiol Endocrinol Metab 2009;296: E462-E472.
36. Remmers F, Verhagen LA, Adan RA, Delemarre-van de Waal HA. Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction. Endocrinology 2008;149:3617-3625.
37. Bi S, Ladenheim EE, Schwartz GJ, Moran TH. A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am J Physiol Regul Integr Comp Physiol 2001;281:R254-R260.
38. Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 2003;285:R1030-R1036.
39. Millington GW. The role of pro-opiomelanocortin (POMC) neurones in feeding behaviour. Nutr Metab 2007;4:18.
40. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999;20:68-100.