Regional grey matter loss and brain disconnection across Alzheimer disease evolution

Current Medicinal Chemistry

Volumn 18, Issue 16, 2011, Pages 2452-2458

  Bozzali, M ^a   Padovani, A ^b   Caltagirone, C ^a,c   Borroni, B ^b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Alzheimer Disease (AD); Diffusion tensor imaging; Disconnection; Mild Cognitive Impairment (MCI); MRI; Tractography; Voxel based morphometry (VBM)

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BRAIN DAMAGE; BRAIN FUNCTION; DIFFUSION TENSOR IMAGING; DISEASE COURSE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAY MATTER; HUMAN; MILD COGNITIVE IMPAIRMENT; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; TEMPORAL LOBE; WHITE MATTER;

ALZHEIMER DISEASE; BRAIN; COGNITION DISORDERS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY;

EID: 79957964104     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711795843263     Document Type: Article

References (60)

1. Blennow, K.; de Leon, M.J.; Zetterberg, H. Alzheimer's disease. Lancet, 2006, 368, 387-403. (Pubitemid 44108123)
2. Loveman, E.; Green, C.; Kirby, J.; Takeda, A.; Picot, J.; Payne, E.; Clegg, A. The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease. Health Technol. Assess., 2006, 10, 1-160.
3. Petersen, R.C.; Doody, R.; Kurz, A.; Mohs, R.C.; Morris, J.C.; Rabins, P.V.; Ritchie, K.; Rossor, M.; Thal, L.; Winblad, B. Current concepts in mild cognitive impairment. Arch. Neurol., 2001, 58, 1985-1992. (Pubitemid 33143977)
4. Stern, Y. Cognitive reserve. Neuropsychologia, 2009, 47, 2015-2028.
5. Mortimer, J.A.; Borenstein, A.R.; Gosche, K.M.; Snowdon, D.A. Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J. Geriatr. Psychiatry Neurol., 2005, 18, 218-223. (Pubitemid 41736387)
6. Perri, R.; Carlesimo, G.A.; Serra, L.; Caltagirone, C. When the amnestic mild cognitive impairment disappears: characterisation of the memory profile. Cogn. Behav. Neurol., 2009, 22, 109-116.
7. Perri, R.; Serra, L.; Carlesimo, G.A.; Caltagirone, C. Amnestic mild cognitive impairment: difference of memory profile in subjects who converted or did not convert to Alzheimer's disease. Neuropsychology, 2007, 21, 549-558. (Pubitemid 47496206)
8. Bozzali,M.; Cercignani,M.; Caltagirone, C. Brain volumetrics to investigate aging and the principal forms of degenerative cognitive decline: A brief review. Magn. Reson. Imaging, 2008, 26,1065-1070.
9. Bozzali, M.; Cherubini, A. Diffusion tensor MRI to investigate dementias: a brief review. Magn. Reson. Imaging, 2007, 25, 969-977. (Pubitemid 47081370)
10. Kantarci, K. 1H magnetic resonance spectroscopy in dementia. Br. J. Radiol. 2007; Spec No 2, S146-152.
11. Falini, A.; Bozzali, M.; Magnani, G.; Pero, G.; Gambini, A.; Benedetti, M.; Mossini, R.; Franceschi, M.; Comi, G.; Scotti, G.; Filippi, M. A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage, 2005, 26: 1159-1163. (Pubitemid 40806494)
12. Dickerson, B.C.; Sperling, R.A. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia, 2008, 46: 1624-1635.
13. Lenzi, D.; Serra, L.; Perri, R.; Pantano, P.; Lenzi, G.L.; Paulesu, E.; Caltagirone, C.; Bozzali, M.; Macaluso, E. Single domain amnesic MCI: a multiple cognitive domains fMRI investigation. Neurobiol. Aging, in press.
14. Mantini, D.; Perrucci, M.G.; Del Gratta, C.; Romani, G.L.; Corbetta, M. Electrophysiological signatures of resting state networks in the human brain. Proc. Natl. Acad. Sci. USA., 2007, 104, 13170-13175. (Pubitemid 351737611)
15. Good, C.D.; Johnsrude, I.S.; Ashburner, J.; Henson, R.N.; Friston, K.J.; Frackowiak, R.S. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage, 2001, 14, 21-36. (Pubitemid 32552740)
16. Karas, G.B.; Burton, E.J.; Rombouts, S.A.; van Schijndel, R.A.; O'Brien, J.T.; Scheltens, P.; McKeith, I.G.; Williams, D.; Ballard, C.; Barkhof, F. A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry. NeuroImage, 2003, 18, 895-907. (Pubitemid 36513463)
17. Bozzali, M.; Filippi, M.; Magnani, G.; Cercignani, M.; Franceschi, M.; Schiatti, E.; Castiglioni, S.; Mossini, R.; Falautano, M.; Scotti, G.; Comi, G.; Falini, A. The contribution of voxel based morphometry in staging patients with mild cognitive impairment. Neurology, 2006, 67, 453-460. (Pubitemid 44214970)
18. Serra, L.; Cercignani, M.; Lenzi, D.; Perri, R.; Fadda, F.; Caltagirone, C.; Macaluso, E.; Bozzali, M. Grey and white matter changes at different stages of Alzheimer's disease. J. Alzheimers Dis., 2010, 19, 147-159.
19. Le Bihan, D. Molecular diffusion nuclear magnetic resonance imaging. Magnetic resonance quarterly vol 7 (1). New York7 Raven Press; 1991. pp. 1-30.
20. Basser, P.J.; Mattiello, J.; LeBihan, D. MR diffusion tensor spectroscopy and imaging. Biophys. J., 1994, 66, 259-267. (Pubitemid 24016507)
21. Pierpaoli, C.; Basser, P.J. Toward a quantitative assessment of diffusion anisotropy. Magn. Reson. Med. 1996, 36, 893-906. (Pubitemid 26396817)
22. Smith, S.M.; Jenkinson, M.; Johansen-Berg, H.; Rueckert, D.; Nichols, T.E.; Mackay, C.E.; Watkins, K.E.; Ciccarelli, O.; Cader, M.Z.; Matthews, P.M.; Behrens, T.E. Tract-based spatial statistics: voxelwise analysis of multisubject diffusion data. Neuroimage, 2006, 31, 1487-1505.
23. Bozzali, M.; Parker, G.J.M.; Serra, L.; Embleton, K.; Gili, T.; Perri, R.; Caltagirone, C.; Cercignani, M. Anatomical connectivity mapping: how to combine structural and functional information. NeuroImage, 2011, 54, 2045-2051.
24. Logothetis, N.K.; Pauls, J.; Augath, M.; Trinath, T.; Oeltermann, A. Neurophysiological investigation of the basis of the fMRI signal. Nature, 2001, 412, 150-157. (Pubitemid 32674704)
25. Dickerson, B.C.; Salat, D.H.; Bates, J.F.; Atiya, M.; Killiany, R.J.; Greve, D.N.; Dale, A.M.; Stern, C.E.; Blacker, D.; Albert, M.S.; Sperling, R.A. Medial temporal lobe function and structure in mild cognitive impairment. Ann. Neurol., 2004, 56, 27-35. (Pubitemid 38857357)
26. Dickerson, B.C.; Salat, D.H.; Greve, D.N.; Chua, E.F.; Rand-Giovannetti, E.; Rentz, D.M.; Bertram, L.; Mullin, K.; Tanzi, R.E.; Blacker, D.; Albert, M.S.; Sperling, R.A. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology, 2004, 65, 404-411.
27. Grady, C.L.; McIntosh, A.R.; Beig, S.; Keightley, M.L.; Burian, H.; Black, S.E. Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J. Neurosci., 2003, 23, 986-993. (Pubitemid 36206190)
28. Lustig, C.; Snyder, A.Z.; Bhakta, M.; O'Brien, K.C.; McAvoy, M.; Raichle, M.E.; Morris, J.C.; Buckner, R.L. Functional deactivations: change with age and dementia of the Alzheimer type. Proc. Natl. Acad. Sci. USA, 2003, 100, 14504-14509. (Pubitemid 37499266)
29. Greicius, M.D.; Krasnow, B.; Reiss, A.L.; Menon, V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. USA, 2003, 100, 253-258. (Pubitemid 36078061)
30. Raichle, M.E.; MacLeod, A.M.; Snyder, A.Z.; Powers, W.J.; Gusnard, D.A.; Shulman, G.L. A default mode of brain function. Proc. Natl. Acad. Sci. USA, 2001, 98, 676-682. (Pubitemid 32105102)
31. Wang, L., Zang, Y., He, Y., Liang, M., Zhang, X., Tian, L., Wu, T., Jiang, T, Li, K. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI. Neuroimage, 2006, 31, 496-504. (Pubitemid 43776683)
32. Calhoun V.D.; Adali T.; Pearlson G.D.; Pekar J.J. A method for making group inferences from functional MRI data using independent component analysis. Hum. Brain Mapp. 2001, 14, 140-151. (Pubitemid 33032347)
33. Damoiseaux, J.S.; Rombouts, S.A.; Barkhof, F.; Scheltens, P.; Stam, C.J.; Smith, S.M.; Beckmann, C.F. Consistent resting-state networks across healthy subjects. Proc. Natl. Acad. Sci. USA, 2006, 103, 13848-13853. (Pubitemid 44413996)
34. Sorg, C.; Riedl, V.; Muhlau, M.; Calhoun, V.D.; Eichele, T.; Läer, L.; Drzezga, A.; Förstl, H.; Kurz, A.; Zimmer, C.; Wohlschläger, A.M. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2007, 104, 18760-18765. (Pubitemid 350210770)
35. Boxer, A.L.; Rankin, K.P.; Miller, B.L.; Schuff, N.; Weiner, M.; Gorno- Tempini, M.L.; Rosen, H.J. Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia. Arch. Neurol., 2003, 60, 949-956. (Pubitemid 36858354)
36. Janke, A.L.; de Zubicaray, G.; Rose, S.E.; Griffin, M.; Chalk, J.B.; Galloway, G.J. 4D deformation modeling of cortical disease progression in Alzheimer's dementia. Magn. Reson. Med., 2001, 46, 661-666. (Pubitemid 32906134)
37. Serra, L.; Perri, R.; Cercignani, M.; Spanò, B.; Fadda, L.; Marra, C.; Carlesimo, G.A.; Caltagirone, C.; Bozzali, M. Are the Behavioral Symptoms of Alzheimer's Disease Directly Associated with Neurodegeneration? J. Alzheimers Dis., 2010, 21, 627-639.
38. Chételat, G.; Landeau, B.; Eustache, F.; Mézenge, F.; Viader, F.; de la Sayette, V.; Desgranges, B.; Baron, J.C. Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. Neuroimage, 2005, 27, 934-946. (Pubitemid 41317262)
39. Serra, L.; Cercignani, M.; Petrosini, L.; Perri, R.; Fadda, L.; Spanò, B.; Marra, C.; Giubilei, F.; Carlesimo, G.A.; Caltagirone, C.; Bozzali, M. Neuroanatomical correlates of cognitive reserve in Alzheimer's disease. Rejuv. Res., 2011, Jan 4. [Epub ahead of print].
40. Rose, S.E.; Chen, F.; Chalk, J.B.; Zelaya, F.O.; Strugnell, W.E.; Benson, M.; Semple, J.; Doddrell, D.M. Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J. Neurol. Neurosurg. Psychiatry, 2000, 69, 528-530.
41. Bozzali, M.; Falini, A.; Franceschi,M.; Cercignani,M.; Zuffi,M.; Scotti, G.; Comi, G.; Filippi, M. White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging. J. Neurol. Neurosurg. Psychiatry, 2002, 72, 742-746. (Pubitemid 34557017)
42. Nakata, Y.; Sato, N.; Nemoto, K.; Abe, O.; Shikakura, S.; Arima, K.; Furuta, N.; Uno, M.; Hirai, S.; Masutani, Y.; Ohtomo, K.; Barkovich, A.J.; Aoki, S. Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease. Magn. Reson. Imaging, 2009, 27, 347-354.
43. Kiuchi, K.; Morikawa, M.; Taoka, T.; Nagashima, T.; Yamauchi, T.; Makinodan, M.; Norimoto, K.; Hashimoto, K.; Kosaka, J.; Inoue, Y.; Inoue, M.; Kichikawa, K.; Kishimoto, T. Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: a diffusion tensor tractography study. Brain Res., 2009, 1287, 184-191.
44. Bozzali, M.; Giulietti, G.; Basile, B.; Spanò, B.; Serra, L.; Perri, R.; Giubilei, F.; Marra, C.; Caltagirone, C.; Cercignani, M. Damage to the cingulate bundle contributes to Alzhiemer's disease evolution by disconnection mechanism. Hum. Brain Mapp., 2011, in press.
45. Villain, N.; Desgranges, B.; Viader, F.; de la Sayette, V.; Mézenge, F.; Landeau, B.; Baron, J.C.; Eustache, F.; Chételat, G. Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease. J. Neurosci., 2008, 28, 6174-6181.
46. Villain, N.; Fouquet, M.; Baron, J.C.; Mézenge, F.; Landeau, B.; de La Sayette, V.; Viader, F.; Eustache, F.; Desgranges, B.; Chételat, G. Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease. Brain 2010, 133, 3301-3314.
47. Gili, T.; Cercignani, M.; Serra, L.; Perri, R.; Giove, F.; Maraviglia, B.; Caltagirone, C.; Bozzali, M. Regional brain atrophy and functional disconnection across Alzheimer's disease evolution. J. Neurol. Neurosurg. Psychiatry, 2011, 82, 58-66.
48. Scahill, R.I.; Schott, J.M.; Stevens, J.M.; Rossor, M.N.; Fox; N.C. Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI. Proc. Natl. Acad. Sci. USA,, 2002, 99, 4703-4707. (Pubitemid 34286048)
49. Pengas, G.; Hodges, J.R.; Watson, P.; Nestor, P.J. Focal posterior cingulate atrophy in incipient Alzheimer's disease. Neurobiol. Aging 2010, 31, 25-33.
50. Chételat, G.; Villemagne, V.L.; Bourgeat, P.; Pike, K.E.; Jones, G.; Ames, D.; Ellis K.A.; Szoeke, C.; Martins, R.N.; O'Keefe, G.J.; Salvado, O.; Masters, C.L.; Rowe, C.C.; Australian Imaging Biomarkers and Lifestyle Research Group. Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Ann. Neurol. 2010, 67, 317-324.
51. Morikawa, M.; Kiuchi, K.; Taoka, T.; Nagauchi, K.; Kichikawa, K.; Kishimoto, T. Uncinate fasciculus-correlated cognition in Alzheimer's disease: a diffusion tensor imaging study by tractography. Psychogeriatrics, 2010, 10, 15-20.
52. Yasmin, H.; Nakata, Y.; Aoki, S.; Abe, O.; Sato, N.; Nemoto, K.; Arima, K.; Furuta, N.; Uno, M.; Hirai, S.; Masutani, Y.; Ohtomo, K. Diffusion abnormalities of the uncinate fasciculus in Alzheimer's disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract. Neuroradiology, 2008, 50, 293-299.
53. Desimone, R.; Duncan, J. Neural mechanisms of selective visual attention. Ann. Rev. Neurosci., 1995, 18, 193-222.
54. Hopfinger, J.B.; Buonocore, M.H.; Mangun, G.R. The neural mechanisms of top-down attentional control. Nat. Neurosci., 2000, 3, 284-291. (Pubitemid 30140792)
55. Allen, G.; Barnard, H.; McColl, R.; Hester, A.L.; Fields, J.A.; Weiner, M.F.; Ringe, W.K.; Lipton, A.M.; Brooker, M.; McDonald, E.; Rubin, CD; Cullum, C.M. Reduced hippocampal functional connectivity in Alzheimer disease. Arch. Neurol.. 2007, 64, 1482-1487. (Pubitemid 47572671)
56. Greicius, M.D.; Srivastava, G.; Reiss, A.L.; Menon, V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl. Acad. Sci. USA, 2004, 101, 4637-4642. (Pubitemid 38437463)
57. Rombouts, S.A.; Barkhof, F.; Goekoop, R.; Stam, C.J.; Scheltens, P. Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study. Hum. Brain Mapp., 2005; 26,231-239. (Pubitemid 41759880)
58. Damoiseaux, J.; Beckmann, C.F.; Arigita, E.J.; Barkhof, F.; Scheltens, P.; Stam, C.J.; Smith, S.M.; Rombouts, S.A. Reduced resting state activity in the dorsal visuo-spatial attention system in Alzheimer's disease. Neuroimage, 2008; 41, S144.
59. Anchisi, D.; Borroni, B.; Franceschi, M.; Kerrouche, N.; Kalbe, E.; Beuthien-Beumann, B.; Cappa, S.; Lenz, O.; Ludecke, S.; Marcone, A.; Mielke, R.; Ortelli, P.; Padovani, A.; Pelati, O.; Pupi, A.; Scarpini, E.; Weisenbach, S.; Herholz, K.; Salmon, E.; Holthoff, V.; Sorbi, S.; Fazio, F.; Perani D. Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Arch. Neurol., 2005, 62, 1728-1733. (Pubitemid 41626670)
60. Braak, H.; Braak, E. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol., 1991, 1, 213-216.