Involvement of PI3K/Akt/CREB and redox changes in mitochondrial defect of osteoblastic MC3T3-E1 cells

Toxicology in Vitro

Volumn 25, Issue 5, 2011, Pages 1085-1088

  Choi, Eun Mi ^a   Lee, Young Soon ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Antimycin A; Mitochondria; Osteoblast; PI3K Akt CREB; Pyridine nucleotide

Indexed keywords

ACONITATE HYDRATASE; ANTIMYCIN A1; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN REDUCTASE; TROLOX C;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; INTRACELLULAR SIGNALING; MITOCHONDRIAL DNA DISORDER; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; OSTEOBLAST; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; ANTIMYCIN A; CATALASE; CELL LINE; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; KAEMPFEROLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NAD; NADP; OSTEOBLASTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79957958888     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.03.022     Document Type: Article

References (14)

1. Baudry N., Laemmel E., Vicaut E. In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice. involvement of xanthine oxidase and mitochondria. American Journal of Physiology. Heart and Circulatory Physiology 2008, 294(2):H821-828.
2. Beinert H., Kennedy M.C., Stout C.D. Aconitase as iron-sulfur protein, enzyme, and iron-regulatory protein. Chemical Reviews 1996, 96:2335-2374.
3. Berndt C., Lillig C.H., Holmgren A. Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. American Journal of Physiology. Heart and Circulatory Physiology 2007, 292:H1227-H1236.
4. Delaval E., Perichon M., Friguet B. Age-related impairment of mitochondrial matrix aconitase and ATP-stimulated protease in rat liver and heart. European Journal of Biochemistry 2004, 271:4559-4564.
5. Fabregat I., Herrera B., Fernandez M., Alvarez A., Sanchez A., Roncero C., Ventura J.J., Valverde A., Benito M. Epidermal growth factor impairs a cytochrome c/caspase 3 apoptotic pathway induced by transforming growth factor in rat fetal hepatocytes via a phosphoinositide 3-kinase dependent pathway. Hepatology 2000, 32:528-535.
6. Harman D. The biologic clock: the mitochondria?. Journal of the American Geriatrics Society 1972, 20:145-147.
7. Hogan M.C., Stary C.M., Balaban R.S., Combs C.A. NAD(P)H fluorescence imaging of mitochondrial metabolism in contracting Xenopus skeletal muscle fibers: effect of oxygen availability. Journal of Applied Physiology 2005, 98:1420-1426.
8. Myers J.M., Myers C.R. The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells. Free Radical Biology and Medicine 2009, 47:1477-1485.
9. Orrenius S., Gogvadze V., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annual Review of Pharmacology and Toxicology 2007, 47:143-183.
10. Pollak N., Dolle C., Ziegler M. The power to reduce pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal 2007, 402:205-218.
11. Putcha G., Deshmukh M., Johnson E. BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, Bcl-2 and caspases. Journal of Neuroscience 1999, 19:7476-7485.
12. Quarles L.D., Yohay D.A., Lever L.W., Caton R., Wenstrup R.J. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. Journal of Bone and Mineral Research 1992, 7:683-690.
13. Wu G.Y., Deisseroth K., Tsien R.W. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(5):2808-2813.
14. Yusta B., Boushey R., Drucker D. The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent, protein kinase-independent pathway. Journal of Biological Chemistry 2001, 275:35345-35352.