2D-LC analysis of BRP 3 erythropoietin N-glycosylation using anion exchange fractionation and hydrophilic interaction UPLC reveals long poly-N-acetyl lactosamine extensions

Analytical Chemistry

Volumn 83, Issue 11, 2011, Pages 4154-4162

  Bones, Jonathan ^a,b   McLoughlin, Niaobh ^a   Hilliard, Mark ^a   Wynne, Kieran ^a   Karger, Barry L ^b   Rudd, Pauline M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION EXCHANGE; COMPREHENSIVE ANALYSIS; GLYCANS; HYDROPHILIC INTERACTION; MICROHETEROGENEITY; N-GLYCANS; N-GLYCOSYLATION; PHARMACOKINETIC PROPERTIES; POST-TRANSLATIONAL MODIFICATIONS; REGULATORY REQUIREMENTS; SIALIC ACIDS; SITE-SPECIFIC;

AMINO ACIDS; CARBOXYLIC ACIDS; ESTERIFICATION; GLYCOPROTEINS; HYDROPHILICITY;

GLYCOSYLATION;

ASPARAGINE; ERYTHROPOIETIN; POLY N ACETYLLACTOSAMINE; POLY-N-ACETYLLACTOSAMINE; POLYSACCHARIDE; SIALIC ACID DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PEPTIDE MAPPING; STANDARD;

AMINO ACID SEQUENCE; ASPARAGINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ERYTHROPOIETIN; GLYCOSYLATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; POLYSACCHARIDES; SIALIC ACIDS;

EID: 79957953469     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200406z     Document Type: Article

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