Effect of recombinant human basic fibroblast growth factor on stomach ulcers in rats and mice

Acta Pharmacologica Sinica

Volumn 20, Issue 8, 1999, Pages 763-768

  Wang, Jun Zhi ^a   Wu, Yong Jie ^b   Rao, Chun Ming ^a   Cao, Ming Tang ^b   Li, Wen Guang ^b  

^a NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^b LANZHOU MEDICAL COLLEGE   (China)

Author keywords

Basic fibroblast growth factor; Famotidine; Granulation tissue; Peptic ulcer; Reserpine

Indexed keywords

ACETIC ACID; FAMOTIDINE; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEMALE; MALE; MOUSE; NONHUMAN; RAT; STOMACH ULCER; TREATMENT OUTCOME; ULCER HEALING;

ACETIC ACID; ANIMALS; DNA; FEMALE; FIBROBLAST GROWTH FACTOR 2; GASTRIC MUCOSA; LIGATION; MALE; MICE; RATS; RECOMBINANT PROTEINS; RESERPINE; RNA; STOMACH ULCER; STRESS;

EID: 0032844048     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze A, Jadus M. Growth factors: new 'endogenous drugs' for ulcer healing. Scand J Gastroenterol Suppl 1995; 210: 15-8.
2. Konturek SJ, Brzozowski T, Majka J, Szlachcic A, Bielanski W, Stachura J, et al. Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate. Gut 1993; 34: 881-7.
3. Shay H, Komarov SA, Fels SS, Meranze D, Grunstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1915; 5: 43-61.
4. Okabe S, Takata Y, Takeuchi K, Naganuma T, Takagi K. Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals. Am J Dig Dis 1976; 21: 618-25.
5. Anson ML. The estimation of pepsin, trypsin, papain and cathepepsin with hemoglobin. J Gen Physiol 1938; 22:79-89.
6. Du ZM. Applied technique of histology. 2nd ed. Beijing: The People's Medical Publishing House; 1998. p 70-1.
7. Cheng Q. Research methodology for pharmacology of traditional Chinese medicine. 1st ed. Beijing: The People's Medical Publishing House; 1993. p821-4.
8. Szabo S, Kusstatscher S, Sandor Z, Sakoulas G. Molecular and cellular basis of ulcer healing. Scand J Gastroenterol Suppl 1995; 208: 3-8.
9. Kitajima M, Nakamura M, Tsuchiya M. Effect of basic fibroblast growth factor on the microvascular regeneration from gastric ulcerative lesion-increased binding site of bFGF after CS23 treatment. Microvasc Res 1995; 50: 133-8.
10. Li CG, Zhang XM, Deng HZ. Methods for pharmacological experiment. 1st ed. Beijing: Chemistry & Industry Press; 1981. p631-5.
11. Tamawski A, Tanoue K, Santos AM, Sarfeh IJ. Cellular and molecular mechanisms gastric ulcer healing. Is the quality of mucosal scar affected by treatment. Scand J Gastroenterol Suppl 1995; 210: 9-14.
12. Hanscom DH, Buchman E. The veterans administration cooperative study on gastric ulcer. 4. The follow-up period. Gastroenterology 1971; 61(4 Suppl 2): 585-91.