Nanoparticle-assisted MALDI-TOF MS combined with seed-layer surface preparation for quantification of small molecules

Analytica Chimica Acta

Volumn 697, Issue 1-2, 2011, Pages 1-7

  Ho, Yi Chi ^a   Tseng, Mei Chun ^b   Lu, Ying Wei ^c   Lin, Chun Cheng ^c   Chen, Yu Ju ^b   Fuh, Ming Ren ^a  

^a SOOCHOW UNIVERSITY   (Taiwan)

^b INSTITUTE OF CHEMISTRY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF MS); Nanoparticle; Quantification; Seed layer method; Small molecules

Indexed keywords

2 ,5-DIHYDROXYBENZOIC ACIDS; ANALYTES; BACKGROUND NOISE; COMPONENTS IN URINE; DETECTION LIMITS; HIGH-THROUGHPUT DETECTION; HOMOGENEOUS SAMPLES; ION SUPPRESSION; LIQUID-LIQUID EXTRACTION; LOW MOLECULAR WEIGHT; MAGNETIC NANOPARTICLES; MALDI TOF MS; MATRIX; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; MODEL COMPOUND; NEW STRATEGY; QUANTIFICATION; QUANTITATIVE ANALYSIS; RAPID IDENTIFICATION; SAMPLE HOMOGENEITY; SAMPLE PRETREATMENT; SAMPLE SURFACE; SEED LAYER; SIGNAL FLUCTUATIONS; SIGNAL VARIATIONS; SMALL MOLECULES; SURFACE PREPARATION; TIME OF FLIGHT MASS SPECTROMETRY; URINE SAMPLE;

BODY FLUIDS; DESORPTION; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MOLECULES; NANOPARTICLES; ORGANIC POLYMERS; POLYACRYLATES; SIGNAL DETECTION; SOLVENT EXTRACTION;

NANOMAGNETICS;

7 AMINOFLUNITRAZEPAM; GENTISIC ACID; MORPHINE; NANOPARTICLE;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG DETERMINATION; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIQUID LIQUID EXTRACTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SEED LAYER METHOD; URINALYSIS;

ANALYTIC SAMPLE PREPARATION METHODS; CHEMICAL FRACTIONATION; FEASIBILITY STUDIES; FLUNITRAZEPAM; GENTISATES; LIMIT OF DETECTION; LINEAR MODELS; MAGNETICS; MOLECULAR WEIGHT; MORPHINE; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PROPERTIES; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 79957942153     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2011.04.008     Document Type: Article

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