A sensitive GC-MS procedure for the analysis of flunitrazepam and its metabolites in urine

Journal of Analytical Toxicology

Volumn 21, Issue 5, 1997, Pages 335-340

  ElSohly, Mahmoud A ^a   Feng, Shixia ^a   Salamone, Salvatore J ^b   Wu, Robert ^b  

^a ElSohly Laboratories Incorporated   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; FLUNITRAZEPAM;

ARTICLE; DRUG ABUSE; DRUG DETERMINATION; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; SLEEP; URINALYSIS;

EID: 0030866367     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/21.5.335     Document Type: Article

References (4)

1. C. Wendt. Schicksal des hypnotikums flunitrazepam im menschlichen organismus. In Bisherige Erfahrungen mit Rohypnol (flunitrazepam) in der Anasthesiologie und Intensivtherapie. W. Huegin, C. Hossli, and M. Gemperle, Eds. Hoffmann-LaRoche, Basel, Switzerland, 1976. pp 27-39.
2. S. Salamone, S. Honasoge, C. Brenner, A.J. McNally, J. Passarelli, K. Goc-Szkutnicka, R. Brenneisen, M.A. ElSohly, and S. Feng. Flunitrazepam excretion patterns using the Abuscreen OnTrak and OnLine immunoassays: comparison with GC-MS. J. Anal. Toxicol. 21: 341-45 (1997).
3. N. De Giovanni and M. Chiarotti. Analysis of benzodiazepines II. High-performance liquid chromatography/fluorescence detection after molecular rearrangement to acridanones. J. Chromatogr. 428: 321-29 (1988).
4. 18 cartridges and wide-bore capillary gas chromatography of benzophenones, the acid-hydrolysis products of benzodiazepines. J. Anal. Toxicol. 15: 21-24 (1991).