Protective effect of natural antioxidants on heart against ischemia- reperfusion damage

Current Pharmaceutical Biotechnology

Volumn 11, Issue 8, 2010, Pages 868-874

  Zhao, Yan ^a   Zhao, Baolu ^b  

^a HARBIN INSTITUTE OF TECHNOLOGY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Free radicals; Heart disease; Ischemiareperfusion; Natural antioxidants; Oxidative stress; Reactive nitrogen species (RNS); Reactive oxygen species (ROS)

Indexed keywords

ANTIOXIDANT; CHINONIN; DOXORUBICIN; FLAVONOID; GINKGO BILOBA EXTRACT; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TACROLIMUS; TANSHINONE; UNCLASSIFIED DRUG; CARDIOTONIC AGENT; REACTIVE NITROGEN SPECIES;

APOPTOSIS; GINKGO BILOBA; HEART ARRHYTHMIA; HEART ISCHEMIA REPERFUSION INJURY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY; REVIEW; SALVIA MILTIORRIZA; DRUG EFFECT; HEART DISEASE; HEART MUSCLE; METABOLISM; PATHOPHYSIOLOGY;

ANTIOXIDANTS; CARDIOTONIC AGENTS; HEART DISEASES; HUMANS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

EID: 79957937727     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920110793262105     Document Type: Review

References (59)

1. Ferrari, R.; Guardigli, G.; Mele, D.; Percoco, G. F.; Ceconi, C.; Curello, S. Oxidative stress during myocardial ischaemia and heart failure. Curr. Pharm. Des. 2004, 10. 1699-1711.
2. Zweier, J. L.; Flaherty, J. T.; Weisfeldt, M. L. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA. 1987, 84. 1404-1407.
3. Zweier, J.L.; Kuppusamy, P.; Williams, R.; Rayburn, B.K.; Smith, D.; Weisfeld, M.L.; Flahery, J.T. Measurement and charactrization of postischemic free radical generation in the isolated perfused heart. J. Biol. Chem., 1989, 261. 18890-18895.
4. Zhao, B-L.; Shen, J-G.; Li, M.; Xin, W-J. Synergic effect of NO and oxygen free radicals in ischemia-reperfusion rabbit myocardium. Sci. China. 1996, 26. 331-338.
5. Zhao, B-L.; Xin, W-J.; Yang, W-D.; Zhu, H-L. Direct measurement of active oxygen free radicals from ischemia-reperfusion rabbit myocardium. Chin. Sci. Bull., 1989, 34. 780-787.
6. Cheng, S.; Zhao, B-L.; Xin, W.J.; Tang, Z-S. Myocadium damage during ischemia-reperfusion of rat heart. Chin. Circ. 1990, 5, 222-226.
7. Huang, N.; Chen, Y.; Zhao, B-L.; Xin, W-J. Studies on free radicals generated during ischemia-reperfusion of rat heat. J. Chin. Med., 1990, 70. 691-694.
8. Zweier, J.L.; Rayburn, B.K.; Flaherty, J.T.; Weisfeldt, M.L. The effect of superoxide dismutatase on free radical concentration in post ischemic myocardium. Circulation, 1986, 74. 371-380.
9. Sanders, S. P.; Zweier, J. L.; Kuppusamy, P.; Harrison, S. J.; Bassett, D. J.; Gabrielson, E. W.; Sylvester, J. T. Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport. J. Clin. Invest., 1993, 91. 46-52.
10. Zweier, J. L.; Kuppusamy, P. In vivo EPR spectroscopy of free radicals in the heart. Environ. Health Perspect. 1994, 102(Suppl 10), 45-51.
11. Kuppusamy, P.; Chzhan, M.; Vij, K.; Shteynbuk, M.; Lefer, D. J.; Giannella, E.; Zweier, J. L. Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation. Proc. Natl. Acad. Sci. USA, 1994, 91. 3388-3392.
12. Zhao, B-L.; Shen, J-G.; Li, M.; Xin, W-J. Scavenging effect of Chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocadium. Biachem. Biophys. Acta, 1996, 1317, 131-137.
13. Afanas'ev, I.B. On mechanism of superoxide signaling under physiological and pathophysiological conditions. Med. Hypotheses, 2005, 64. 127-129.
14. Linnane, A.W.; Kios, M.; Vitetta, L. The essential requirement for superoxide radical and nitric oxide formation for normal physiological function and healthy aging. Mitochondrion, 2007, 7. 1-5.
15. Zhao, B-L.; Jiang, W.; Zhao, Y.; Hou, J-W.; Xin, W-J. Scavenging effect of salvia miltiorriza on free radicals and its protection for myocardial mitochondrial membrane from ischemia-reperfusion injury. Biochem. Mol. Biol. Intern., 1996, 38. 1171-1182.
16. Shen, J-G.; Wang, J.; Zhao, B-L.; Hou, J-W.; Gao, T-L.; Xin, W-J. Effects of EGb-761 on nitric oxide, oxygen free radicals, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Biochim. Biophys. Acta, 1998, 1406, 228-236.
17. Zou, X-L.;Wan, Q.; Li, M-F.; Zhao, B-L.; Xin, W-J. Scavenging effect of green tea polyphenols on oxygen free radicals generated from ischemia-reperfused myocardium. Chin. J. Magn. Reson., 1995, 12. 237-244.
18. Shen, J-G.; Guo, X-S.; Jiang, B.; Li, M.; Xin, W-J.; Zhao, B-L. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochim. Biophyscs. Acta, 2000, 1500. 217-226.
19. Shen, J-G.; Li M.; Xin, W-J.; Zhao, B-L. Effects of Chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Appl. Magn. Reson., 2000, 19. 9-19.
20. Zhao, B-L.; Zhou, W-A.; Ni, Y-C.; Hou, J-W.; Gao, T-L.; Xin, W-J. Kinetic scavenging effects of chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocardium and its protection effects on the myocardium. Res. Chem. Intermed., 2000, 26. 747-762.
21. Bredt, D.S.; Hwang, P.M.; Snyder S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 1990, 34. (6295), 768-770.
22. Li, H-T.; Zhao, B-L.; Hou, J-W.; Xin W-J. Two peak kinetic curve of chemiluninencence in phorbol stimulated macrophage. Biochem. Biophys. Res. Commn., 1996, 223. 311-314.
23. Ghafourifar, P.; Schenk, U.; Klein, S.D.; Richter C. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J. Biol. Chem., 1999, 274. 31185-31188.
24. Zhao, B-L.; Shen, J-G.; Li, M.; Xin, W-J. Study on NO free radicals generated from ischemia-reperfused heart and macrophage. Chinese J. Magn. Reson., 1997, 14. 99-106.
25. 2+. Chin. J. Magn. Reson., 1998, 15, 307,311.
26. Zhang, D.-L.; Xiong, J.; Hu, J.; Li, Y.; Zhao, B.-L. improved method to detect nitric oxide in biological syste. Appl. Magn. Reson., 2001, 20. 345-358.
27. Zhou, G-Y.; Zhao, B-L.; Hou, J-W.; Li, M-F.; Chen, C.; Xin, W-J. Detection of nitric oxide in tissue by spin trapping EPR spectropy and triacetylglycerol extraction. Biotech. Tech., 1999, 13. 507-511.
28. Zhang, P.; Xu, X.; Hu, X.; Deel, E.; Zhu, G.; Chen, Y. iNOS deficiency protects the heart from systolic overload induced ventricular hypertrophy and congestive heart failure. Circ. Res., 2007, 100. 1089-1098.
29. Bolli, R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J. Mol. Cell Cardiol., 2001, 33,1897-1918.
30. Beckman J.S.; Koppenol W.H. Nitric oxide, superoxide and peroxynitrite: The good, the bad, and the ugly. Am. J. Physiol., 1996, 271. C1424-C1437.
31. Shen, J-G.; Qiu, X-S.; Jiang, B.; Zhang D-L.; Xin W-J.; Fung, P.C.W.; Zhao, B-L. Nitric oxide contributes to redistribution of phosphatidylserine and triggers apoptosis via peroxynitrite and p53 pathway in hypoxia-reoxygenated Cardiomyocytes. Sci. China, 2003, 46. 27-39.
32. Troy, C.M.; Derossi, D.; Prochianz, A.; Greene, L.A.; Shelanski, M.L. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci., 1996, 16. 253-261.
33. Chen, Y. R.; Chen, C. L.; Pfeiffer, D. R.; Zweier, J. L. Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation. J. Biol. Chem., 2007, 282. 32640-32654.
34. Chen, C-L.; Chen, J.; Rawale, S.; Varadharaj, S.; Kaumaya, P. P. T.; Zweier, J. L.; Chen, Y-R. Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex ii in the post-ischemic myocardium. J. Biol. Chem., 2008, 283. 27991-28003.
35. Young, L.H. AMP-activated protein kinase conducts the ischemic stress response orchestra. Circulation, 2008, 117. 832-840.
36. Li, J.; Hu, X.; Selvakumar, P.; Russell, R.R.; Cushman, S.W.; Holman, G. D.; Young, L.H. Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am. J. Physiol., 2004, 287. E834-E841.
37. Terai, K.; Hiramoto, Y.; Masaki, M.; Sugiyama, S.; Kuroda, T.; Hori, M.; Kawase, I.; Hirota, H. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol. Cell Biol., 2005, 25. 9554-9575.
38. Li, J.; Miller, E. J.; Ninomiya-Tsuji, J.; Russell, R.R. Young, L.H. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ. Res. 2005, 97. 872-879.
39. Zhang, P.; Hu, X.; Fassett, J. E.; Zhu, G.; Viollet, B.; Xu, W.; Wiczer, B.; Bernlohr, D.A.; Bache, R. J.; Chen, Y. AMPKδ2 deficiency exacerbates pressure-overload induced left ventricular hypertrophy and dysfunction in mice. Hypertension, 2008, 52. 918-924.
40. Chen, W.; Dong, Y.; Wang, C.; Ting, G. Pharmacological studies of sodium tanshinone IIA sulfonate. Acta Pharmacol. Sin., 1979, 14. 277-283.
41. Yang, W.; Zhu, H.L.; Zhao, B.L. Scavenging effect of tanshinone on free radicals. Bult. Chin. Pharmacol. 1990, 6. 118-123.
42. Ma, Z.; Zhao, B-L.; Yuan, Z. Application of electrochemical and spin trapping techniques in the investigating the scavenging effect of tanshinone on hydroxyl radicals. Anal. Chem. Acta. 1999, 389. 213-218.
43. Jiang, W.; Zhao, Y.; Wan, Q.; Zhao, B-L.; Xin, W-J. Scavenging effect of salviol (Tanshinone) on the lipid free radicals generated from lipid peroxidation in sarcoplasma. Acta Biophys. Sin. 1994, 10. 685-689.
44. Zhao, Y.; Jiang, W.; Hou, J-W.; Zhao, B-L.; Xin, W-J. Effect of calcium overload and salviol (Tanshinone) on the lipid free radicals generated from lipid peroxidation of mitochondrial membrane. Chin. J. Biochem. Biophys. 1995, 28. 269-276.
45. Zhou, G-Y.; Jiang, W.; Zhao, Y.; Ma, G-E.; Xin, W-J.; Yin, J.; Zhao, B-L. Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem. Biopharm. 2003, 7465,1-7.
46. Keizer, H.G.; Pinedo, H.M.; Schuurhuis, G.J.; Joenje, H. Doxorubin Adriamycin: A critical review of free radical-dependent mechanism of cyotoxicity. Pharmacol. Ther., 1990, 47. 219-231.
47. Zhou, G-Y.; Jiang W.; Zhao, Y.; Ma, G-E.; Li, S-G.; Xin, W-J.; Zhao, B-L. Interaction between sodium tanshinone IIA sulfonate and the adriamycin semiquinone free radical: A possible mechanism for antagonizing adriamycin-induced cardiotoxity. Res. Chem. Interm., 2002, 28, 277-290.
48. Yang, W.; Zhu, H.L.; Zhao, B-L. Studied on the free radicals generated during ischemia-reperfusion heart and scavenging effect of tanshinone on the free radicals. Chin. Myovasc. J., 1989, 17. 178-194.
49. Tredici, P. D. Ginkgos and people-A thousand years of interactions, Arnoldia, 1991, 51. 2-15.
50. Tosaki, A.; Droy-Lefaix, M.T.; Pali, T.; Das, D.K. Effects of SOD, catalase, and a novel antiarrhythmic drug, EGB 761, on reperfusion-induced arrhythmias in isolated rat hearts. Free Radic. Biol. Med., 1993, 14. 361-370.
51. Haramaki, N.; Aggarwal, S.; Kawabata, T.; Droy-Lefaix, M.T.; Packer, L. Effects of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury. Free Radic. Biol. Med., 1994, 16. 789-794.
52. Shen, J-G.; Zhao, B-L.; Li, M-F.; Wan, Q.; Xin, W-J. Inhibitory effects of Ginkgo biloba extract (EGB761) on oxygen free radicals, nitric oxide and myocardial injury in isolated ischemic-reperfusion hearts. In: Proceedings of the International Symposium on Natural Antioxidants Molecular Mechanisms and Health Effects; Packer, L.; Traber, M.G.; Xin, W.; Raber, M.G.; Xin, W., Eds.: AOCS Press: Champaign, Illinois, 1996.
53. DeFeudis, F.V. Ginkgo biloba extract (EGb 761): pharmacological activities and clinical application. Amsterdam, Elsevier, London, Paris, New Yourk, Tokyo, 1991.
54. Varga, E.; Bodi, A.; Ferdinandy, P.; Droy-Lefaix, M.T.; Blasig, I.E.; Tosaki, A. The protective effect of EGb 761 in isolated ischemic/reperfused rat hearts: a link between cardiac function and nitric oxide production. J. Cardiovasc. Pharmacol., 1999, 34,711-717.
55. Kusmic, C.; Basta, G.; Lazzerini, G.; Vesentini, N.; Barsacchi, R. The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart: a link between vitamin E preservation and prostaglandin biosynthesis. J. Cardiovasc. Pharmacol., 2004, 44. 356-362.
56. Furchgott, R.; Zawadzki, J.V. The obligatory role of the endothelium in the relaxation of arterial smooth muscle by acetycholine. Nature. 1980, 288. 373-376.
57. Ignarro, L.J.; Byrns, R.E.; Wood, K.S. Pharmacological and biological properties of endothelium-derived relaxing factor(EDRF): Evidence that EDRF is closely related to nitric oxide radical. Circulation, 1986, 74(2), 287.
58. Haines, D.D.; Bak, I.; Ferdinandy, P.; Mahmoud, F.F.; Al-Harbi, S.A.; Blasig, I. E; Tosaki, A. Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. J. Cardiovasc. Pharmacol. 2000, 35. 37-44.
59. Zhao, B-L.; Shen, J-G.; Li, M.; Wan, Q.; Li, M-F.; Xin, W-J. In: Chinonin Can Scavenging No Free Radicals and Protect the Myocardium Against Ischemia-Reperfusion Injury. Proceedings of the international symposium on natural antioxidants Molecular mechanisms and health effects. Packer, L.; Ttaber, M.G.; Xin, W. Eds.; AOCS Press: Champaign, Illinois, 1996.