Phase I study to assess the safety, Tolerability and pharmacokinetics of AZD4877 in japanese patients with solid tumors

Archives of Drug Information

Volumn 4, Issue 2, 2011, Pages 23-31

  Esaki, Taito ^a   Seto, Takashi ^a   Ariyama, Hiroshi ^a   Arita, Shuji ^a   Fujimoto, Chinatsu ^a   Tsukasa, Koichiro ^a   Kometani, Takuro ^a   Nosaki, Kaname ^a   Hirai, Fumihiko ^a   Yagawa, Katsuro ^b  

^a NATIONAL KYUSHU CANCER CENTER   (Japan)

^b ASTRAZENECA   (United Kingdom)

Author keywords

AZD4877; Eg5 Inhibitor; Japanese; Solid Tumors

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 4877; CASPASE CLEAVED CYTOKERATIN 18; CYTOKERATIN 18; UNCLASSIFIED DRUG;

ABNORMAL LABORATORY RESULT; ADULT; AGED; ANOREXIA; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; BREAST CANCER; CANCER GRADING; CLINICAL ARTICLE; COHORT ANALYSIS; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FEVER; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; INSOMNIA; JAPANESE; KIDNEY CANCER; LEUKOPENIA; LUNG CANCER; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MALE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROSTATE CANCER; RASH; RHINOPHARYNGITIS; SIDE EFFECT; SODIUM BLOOD LEVEL; SOLID TUMOR; THROMBOCYTOPENIA; THYMUS CANCER; TREATMENT RESPONSE; URETER CANCER; URINARY TRACT INFECTION; VOMITING;

EID: 79957923729     PISSN: None     EISSN: 17535174     Source Type: Journal    
DOI: 10.1111/j.1753-5174.2011.00034.x     Document Type: Article

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