Rapid Detection of Ricin in Milk Using Immunomagnetic Separation Combined with Surface-Enhanced Raman Spectroscopy

Journal of Food Science

Volumn 76, Issue 5, 2011, Pages

  He, Lili ^a   Deen, Bronwyn ^a   Rodda, Tom ^a   Ronningen, Ian ^a   Blasius, Tim ^a   Haynes, Christy ^a   Diez Gonzalez, Francisco ^a   Labuza, Theodore P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

IMS; Milk; Portable Raman; Ricin; SERS

Indexed keywords

METAL NANOPARTICLE; RICIN; SILVER;

ANIMAL; ARTICLE; CHEMISTRY; IMMUNOMAGNETIC SEPARATION; INSTRUMENTATION; METHODOLOGY; MILK; PRINCIPAL COMPONENT ANALYSIS; RAMAN SPECTROMETRY;

ANIMALS; IMMUNOMAGNETIC SEPARATION; METAL NANOPARTICLES; MILK; PRINCIPAL COMPONENT ANALYSIS; RICIN; SILVER; SPECTRUM ANALYSIS, RAMAN;

EID: 79957911143     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2011.02196.x     Document Type: Article

References (25)

1. Balint GA. 1974. Ricin: the toxic protein of castor oil seeds. Toxicol 2(1):77-102.
2. Bradberry SM, Dickers KJ, Rice P, Griffiths GD, Vale JA. 2003. Ricin poisoning. Toxicol Rev 22(1):65-70.
3. Brzezinski JL, Craft DL. 2007. Evaluation of an in vitro bioassay for the detection of purified ricin and castor bean in beverages and liquid food matrices. J Food Prot 70(10):2377-82.
4. Challoner KR, McCarron MM. 1990. Castor bean intoxication. Ann Emerg Med 19(10):1177-83.
5. Chu H, Huang Y, Zhao Y. 2008. Silver nanorod arrays as a surface-enhanced Raman scattering substrate for foodborne pathogenic bacteria detection. Appl Spectrosc 62(8):922-31.
6. Cole KD, Gaigalas A, Almeida JL. 2008. Process monitoring the inactivation of ricin and model proteins by disinfectants using fluorescence and biological activity. Biotechnol Progr 24(3):784-91.
7. Dayan-Kenigsberg J, Bertocchi A, Garber EA. 2008. Rapid detection of ricin in cosmetics and elimination of artifacts associated with wheat lectin. J Immunol Methods 336(2):251-254.
8. Garber EA. 2008. Toxicity and detection of ricin and abrin in beverages. J Food Prot 71(9):1875-83.
9. Garber EA, Eppley RM, Stack ME, McLaughlin MA, Park DL. 2005. Feasibility of immunodiagnostic devices for the detection of ricin, amanitin, and T-2 toxin in food. J Food Prot 68(6):1294-301.
10. Garber EA, O'Brien TW. 2008. Detection of ricin in food using electrochemiluminescence-based technology. J AOAC Int 91(2):376-82.
11. Haynes CL, McFarland AD, Van Duyne RP. 2005. Surface-enhanced Raman spectroscopy. Anal Chem 77(17):338-46.
12. He L, Lin M, Li H, Kim N-J. 2009. Surface-enhanced Raman spectroscopy coupled with dendritic silver nanosubstrate for detection of restricted antibiotics. J Raman Sepctrosc 41(7):739-44.
13. He L, Haynes CL, Diez-Gonzalez F, Labuza TP. 2011a. Rapid detection of a foreign protein in milk using IMS-SERS. J Raman Spectrosc. Forthcoming. DOI:
14. He L, Rodda T, Haynes CL, Deschaines T, Strother T, Diez-Gonzalez F, Labuza TP. 2011b. Detection of a foreign protein in milk using surface-enhanced Raman spectroscopy coupled with antibody-modified silver dendrites. Anal Chem 83(5):1510-3.
15. Jones CL, Bantz KC, Haynes CL. 2009. Partition layer-modified substrates for reversible surface-enhanced Raman scattering detection of polycyclic aromatic hydrocarbons. Anal Bioanal Chem 394(1):303-11.
16. Kalb SR, Barr JR. 2009. Mass spectrometric detection of ricin and its activity in food and clinical samples. Anal Chem 81(6):2037-42.
17. Kennedy SP, Busta F. 2007. Biosecurity: food protection and defense. In: Doyle MP, Beuchatt LR, editors. Food microbiology: fundamentals and frontiers. 3rd ed. Washington D.C. : ASM Press. p. 35.
18. Ligler FS, Taitt CR, Shriver-Lake LC, Sapsford KE, Shubin Y, Golden JP. 2003. Array biosensor for detection of toxins. Anal Bioanal Chem 377(3):469-77.
19. Lin M, He L, Awika J, Yang L, Ledoux DR, Li H, Mustapha A. 2008. Detection of melamine in gluten, chicken feed, and processed foods using surface enhanced Raman spectroscopy and HPLC. J Food Sci 73(8):T129-34.
20. Lubelli C, Chatgilialoglu A, Bolognesi A, Strocchi P, Colombatti M, Stirpe F. 2006. Detection of ricin and other ribosome-inactivating proteins by an immuno-polymerase chain reaction assay. Anal Biochem 355(1):102-9.
21. Morin RS, Kozlovac JP. 2000. Biological toxins. In: Fleming DO, Hunt DL, editors. Biological safety: principles and practices. 3rd ed. Washington, D.C. : ASM Press. p. 269-80.
22. Olsnes S, Pihl A. 1973. Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry 12(16):3121-6.
23. Rauber A, Heard J. 1985. Castor bean toxicity re-examined: a new perspective. Vet Hum Toxicol 27(6):498-502.
24. Shyu HF, Chiao DJ, Liu HW, Tang SS. 2002. Monoclonal antibody-based enzyme immunoassay for detection of ricin. Hybrid Hybridomics 21(1):69-73.
25. Wein LM, Liu Y. 2005. Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk. Proc Natl Acad Sci USA 102(28):9984-9.