Transcranial magnetic stimulation and connectivity mapping: Tools for studying the neural bases of brain disorders

Frontiers in Systems Neuroscience

Volumn 4, Issue , 2010, Pages

  Hampson, M ^a   Hoffman, R E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain disorders; Connectivity; Neurology; Psychiatry; Resting; Stimulation; Transcranial magnetic stimulation

Indexed keywords

BRAIN BLOOD FLOW; BRAIN DISEASE; BRAIN MAPPING; ELECTROENCEPHALOGRAM; EPILEPSY; FRONTAL EYE FIELD; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NERVE CELL NETWORK; NEUROIMAGING; NEUROMODULATION; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIMARY MOTOR CORTEX; PRIMARY SOMATOSENSORY CORTEX; REVIEW; STRIATE CORTEX; SUPPLEMENTARY MOTOR AREA; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 79957906022     PISSN: 16625137     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnsys.2010.00040     Document Type: Review

References (90)

1. Allen, E. A., Pasley, B. N., Duong, T., and Freeman, R. D. (2007). Transcranial magnetic stimulation elicits coupled neural and hemodynamic consequences. Science 317, 1918-1921.
2. Bestmann, S., Baudewig, J., Siebner, H. R., Rothwell, J. C., and Frahm, J. (2004). Functional MRI of the immediate impact of transcranial magnetic stimulation on cortical and subcortical motor circuits. Eur. J. Neurosci. 19, 1950-1962.
3. Bestmann, S., Oliviero, A., Voss, M., Dechent, P., Lopez-Dolado, E., Driver, J., and Baudewig, J. (2006). Cortical correlates of TMS-induced phantom hand movements revealed with concurrent TMS-fMRI. Neuropsychologia 44, 2959-2971.
4. Bohning, D. E., Shastri, A., McConnell, K. A., Nahas, Z., Lorberbaum, J. P., Roberts, D. R., Teneback, C., Vincent, D. J., and George, M. S. (1999). A combined TMS/fMRI study of intensity-dependent TMS over motor cortex. Biol. Psychiatry 45, 385-394.
5. Bohning, D. E., Shastri, A., Nahas, Z., Lorberbaum, J. P., Andersen, S. W., Dannels, W. R., Haxthausen, E. U., Vincent, D. J., and George, M. S. (1998). Echoplanar BOLD fMRI of brain activation induced by concurrent transcranial magnetic stimulation. Invest. Radiol. 33, 336-340.
6. Bonato, C., Miniussi, C., and Rossini, P. M. (2006). Transcranial magnetic stimulation and cortical evoked potentials: a TMS/EEG co-registration study. Clin. Neurophysiol. 117, 1699-1707.
7. Boros, K., Poreisz, C., Munchau, A., Paulus, W., and Nitsche, M. A. (2008). Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans. Eur. J. Neurosci. 27, 1292-1300.
8. Bracco, L., Giovannelli, F., Bessi, V., Borgheresi, A., Di Tullio, A., Sorbi, S., Zaccara, G., and Cincotta, M. (2009). Mild cognitive impairment: loss of linguistic task-induced changes in motor cortex excitability. Neurology 72, 928-934.
9. Buhmann, C., Gorsler, A., Baumer, T., Hidding, U., Demiralay, C., Hinkelmann, K., Weiller, C., Siebner, H. R., and Munchau, A. (2004). Abnormal excitability of premotor- motor connections in de novo Parkinson's disease. Brain 127, 2732-2746.
10. Byblow, W. D., Coxon, J. P., Stinear, C. M., Fleming, M. K., Williams, G., Muller, J. F., and Ziemann, U. (2007). Functional connectivity between secondary and primary motor areas underlying handfoot coordination. J. Neurophysiol. 98, 414-422.
11. Casali, A. G., Casarotto, S., Rosanova, M., Mariotti, M., and Massimini, M. (2010). General indices to characterize the electrical response of the cerebral cortex to TMS. Neuroimage 49, 1459-1468.
12. Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., and Cohen, L. G. (1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 48, 1398-1403.
13. Cho, S. S., and Strafella, A. P. (2009). rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulated cortex and orbitofrontal cortex. PLoS ONE 4, e6725. doi:10.1371/journal. pone.0006725.
14. Chouinard, P. A., Leonard, G., and Paus, T. (2006). Changes in effective connectivity of the primary motor cortex in stroke patients after rehabilitative therapy. Exp. Neurol. 201, 375-387.
15. Civardi, C., Cantello, R., Asselman, P., and Rothwell, J. C. (2001). Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans. Neuroimage 14, 1444-1453.
16. Cohen, L. G., Roth, B. J., Nilsson, J., Dang, N., Panizza, M., Bandinelli, S., Friauf, W., and Hallett, M. (1990). Effects of coil design on delivery of focal magnetic stimulation. Technical coninsiderations. Electroencephalogr. Clin. Neurophysiol. 75, 350-357.
17. Conchou, F., Loubinoux, I., Castel-Lacanal, E., Le Tinnier, A., Gerdelat-Mas, A., Faure-Marie, N., Gros, H., Thalamas, C., Calvas, F., Berry, I., Chollet, F., and Simonetta Moreau, M. (2009). Neural substrates of low-frequency repetitive transcranial magnetic stimulation during movement in healthy subjects and acute stroke patients. A PET study. Hum. Brain Mapp. 30, 2542-2557.
18. D'Argenzio, L., Koch, G., Bombardieri, R., Mori, F., Moavero, R., Centonze, D., and Curatolo, P. (2009). Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex. Epilepsy Res. 87, 102-105.
19. Daskalakis, Z. J., Christensen, B. K., Fitzgerald, P. B., Fountain, S. I., and Chen, R. (2005). Reduced cerebellar inhibition in schizophrenia: a preliminary study. Am. J. Psychiatry 162, 1203-1205.
20. Davare, M., Montague, K., Olivier, E., Rothwell, J. C., and Lemon, R. N. (2009). Ventral premotor to primary motor cortical interactions during object-driven grasp in humans. Cortex 45, 1050-1057.
21. Ferrarelli, F., Haraldsson, H. M., Barnhart, T. E., Roberts, A. D., Oakes, T. R., Massimini, M., Stone, C. K., Kalin, N. H., and Tononi, G. (2004). A [17F]-fluoromethane PET/TMS study of effective connectivity. Brain Res. Bull. 64, 103-113.
22. Ferrarelli, F., Massimini, M., Peterson, M. J., Riedner, B. A., Lazar, M., Murphy, M. J., Huber, R., Rosanova, M., Alexander, A. L., Kalin, N., and Tononi, G. (2008). Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. Am. J. Psychiatry 165, 996-1005.
23. Fox, P., Ingham, R., George, M. S., Mayberg, H., Ingham, J., Roby, J., Martin, C., and Jerabek, P. (1997). Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport 8, 2787-2791.
24. Friston, K. J., Harrison, L., and Penny, W. (2003). Dynamic causal modelling. Neuroimage 19, 1273-1302.
25. Fuggetta, G., Fiaschi, A., and Manganotti, P. (2005). Modulation of cortical oscillatory activities induced by varying single-pulse transcranial magnetic stimulation intensity over the left primary motor area: a combined EEG and TMS study. Neuroimage 27, 896-908.
26. Fuggetta, G., Pavone, E. F., Fiaschi, A., and Manganotti, P. (2008). Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex: acombined EEG and TMS study. Hum. Brain Mapp. 29, 1-13.
27. Galea, J. M., Jayaram, G., Ajagbe, L., and Celnik, P. (2009). Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. J. Neurosci. 29, 9115-9122.
28. George, M. S., Lisanby, S. H., and Sackeim, H. A. (1999). Transcranial magnetic stimulation: applications in neuropsychiatry. Arch. Gen. Psychiatry 56, 300-311.
29. Goebel, R., Roebroeck, A., Kim, D. S., and Formisano, E. (2003). Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and Granger causality mapping. Magn. Reson. Imaging 21, 1251-1261.
30. Goto, T., Saitoh, Y., Hashimoto, N., Hirata, M., Kishima, H., Oshino, S., Tani, N., Hosomi, K., Kakigi, R., and Yoshimine, T. (2008). Diffusion tensor fiber tracking in patients with central post-stroke pain; correlation with efficacy of repetitive transcranial magnetic stimulation. Pain 140, 509-518.
31. Grefkes, C., Nowak, D. A., Wang, L. E., Dafotakis, M., Eickhoff, S. B., and Fink, G. R. (2010). Modulating cortical connectivity in stroke patients by rTMS assessed with fMRI and dynamic causal modeling. Neuroimage 50, 233-242.
32. Grosbras, M. H., and Paus, T. (2002). Transcranial magnetic stimulation of the human frontal eye field: effects on visual perception and attention. J. Cogn. Neurosci. 14, 1109-1120.
33. Hampson, M., Shen, X., and Constable, R. T. (in press). "Functional connectivity MR imaging," in Functional Neuroradiology: Principles and Clinical Applications, eds S. Faro and F. Mohamed (New York, NY: Springer Science + Business Media, LLC).
34. Hannula, H., Neuvonen, T., Savolainen, P., Hiltunen, J., Ma, Y. Y., Antila, H., Salonen, O., Carlson, S., and Pertovaara, A. (2010). Increasing top-down suppression from prefrontal cortex facilitates tactile working memory. Neuroimage 49, 1091-1098.
35. Hoffman, R. E., Hampson, M., Wu, K., Anderson, A. W., Gore, J. C., Buchanan, R. J., Constable, R. T., Hawkins, K., Sahay, N., and Krystal, J. H. (2007). Probing the pathophysiology of auditory hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation. Cereb. Cortex 17, 2733-2743.
36. Hofman, D., and Schutter, D. J. (2009). Inside the wire: aggression and functional interhemispheric connectivity in the human brain. Psychophysiology 46, 1054-1058.
37. Huang, Y. Z., Edwards, M. J., Rounis, E., Bhatia, K. P., and Rothwell, J. C. (2005). Theta burst stimulation of the human motor cortex. Neuron 45, 201-206.
38. Husain, F. T., Nandipati, G., Braun, A. R., Cohen, L. G., Tagamets, M. A., and Horwitz, B. (2002). Simulating transcranial magnetic stimulation during PET with a large-scale neural network model of the prefrontal cortex and the visual system. Neuroimage 15, 58-73.
39. Ilmoniemi, R. J., Virtanen, J., Ruohonen, J., Karhu, J., Aronen, H. J., Naatanen, R., and Katila, T. (1997). Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity. Neuroreport 8, 3537-3540.
40. Iramina, K., Maeno, T., Kowatari, Y., and Ueno, S. (2002). Effects of transcranial magnetic stimulation on EEG activity. IEEE Trans. Magn. 38, 3347-3349.
41. Iwahashi, M., Arimatsu, T., Ueno, S., and Iramina, K. (2008). Differences in evoked EEG by transcranial magnetic stimulation at various stimulus points on the head. Proceedings of International Conference of IEEE, Engineering in Medicine and Biology Society, 2008, Vancouver, pp. 2570-2573.
42. Jing, H., and Takigawa, M. (2000). Observation of EEG coherence after repetitive transcranial magnetic stimulation. Clin Neurophysiol 111, 1620-1631.
43. Julkunen, P., Jauhiainen, A. M., Westeren- Punnonen, S., Pirinen, E., Soininen, H., Kononen, M., Paakkonen, A., Maatta, S., and Karhu, J. (2008). Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study. J. Neurosci. Methods 172, 270-276.
44. Ko, J. H., Monchi, O., Ptito, A., Bloomfield, P., Houle, S., and Strafella, A. P. (2008). Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study. Eur. J. Neurosci. 28, 2147-2155.
45. Koch, G., Franca, M., Mochizuki, H., Marconi, B., Caltagirone, C., and Rothwell, J. C. (2007). Interactions between pairs of transcranial magnetic stimuli over the human left dorsal premotor cortex differ from those seen in primary motor cortex. J. Physiol. (Lond.) 578, 551-562.
46. Koch, G., Ribolsi, M., Mori, F., Sacchetti, L., Codeca, C., Rubino, I. A., Siracusano, A., Bernardi, G., and Centonze, D. (2008a). Connectivity between posterior parietal cortex and ipsilateral motor cortex is altered in schizophrenia. Biol. Psychiatry 64, 815-819.
47. Koch, G., Schneider, S., Baumer, T., Franca, M., Munchau, A., Cheeran, B., Fernandez del Olmo, M., Cordivari, C., Rounis, E., Caltagirone, C., Bhatia, K., and Rothwell, J. C. (2008b). Altered dorsal premotor-motor interhemispheric pathway activity in focal arm dystonia. Mov. Disord. 23, 660-668.
48. Laird, A. R., Robbins, J. M., Li, K., Price, L. R., Cykowski, M. D., Narayana, S., Laird, R. W., Franklin, C., and Fox, P. T. (2008). Modeling motor connectivity using TMS/PET and structural equation modeling. Neuroimage 41, 424-436.
49. Lee, L., Siebner, H. R., Rowe, J. B., Rizzo, V., Rothwell, J. C., Frackowiak, R. S., and Friston, K. J. (2003). Acute remapping within the motor system induced by low-frequency repetitive transcranial magnetic stimulation. J. Neurosci. 23, 5308-5318.
50. Levit-Binnun, N., Litvak, V., Pratt, H., Moses, E., Zaroor, M., and Peled, A. (2010). Differences in TMS-evoked responses between schizophrenia patients and healthy controls can be observed without a dedicated EEG system. Clin. Neurophysiol. 121, 332-339.
51. Lioumis, P., Kicic, D., Savolainen, P., Makela, J. P., and Kahkonen, S. (2009). Reproducibility of TMS-evoked EEG responses. Hum. Brain Mapp. 30, 1387-1396.
52. Litvak, V., Komssi, S., Scherg, M., Hoechstetter, K., Classen, J., Zaaroor, M., Pratt, H., and Kahkonen, S. (2007). Artifact correction and source analysis of early electroencephalographic responses evoked by transcranial magnetic stimulation over primary motor cortex. Neuroimage 37, 56-70.
53. Loscher, W. N., Dobesberger, J., Szubski, C., and Trinka, E. (2007). RTMS reveals premotor cortex dysfunction in frontal lobe epilepsy. Epilepsia 48, 359-365.
54. Marrelec, G., Daunizeau, J., Pelegrini-Issac, M., Doyon, J., and Benali, H. (2005). Conditional correlation as a measure of mediated interactivity in fMRI and MEG/EEG. IEEE Trans. Signal Process 53, 3505-3516.
55. McIntosh, A. R., and Gonzalez-Lima, F. (1994). Network interactions among limbic ortices, basal forebrain, and cerebellum differentiate a tone conditioned as a Pavlovian excitor or inhibitor: fluorodeoxyglucose mapping and covariance structural modeling. J. Neurophysiol. 72, 1717-1733.
56. Meister, I. G., Boroojerdi, B., Foltys, H., Sparing, R., Huber, W., and Topper, R. (2003). Motor cortex hand area and speech: implications for the development of language. Neuropsychologia 41, 401-406.
57. Meister, I. G., Sparing, R., Foltys, H., Gebert, D., Huber, W., Topper, R., and Boroojerdi, B. (2006). Functionalconnectivity between cortical hand motor and language areas during recovery from aphasia. J. Neurol. Sci. 247, 165-168.
58. Nahas, Z., Lomarev, M., Roberts, D. R., Shastri, A., Lorberbaum, J. P., Teneback, C., McConnell, K., Vincent, D. J., Li, X., George, M. S., and Bohning, D. E. (2001). Unilateral left prefrontal transcranial magnetic stimulation (TMS) produces intensity-dependent bilateral effects as measured by interleaved BOLD fMRI. Biol. Psychiatry 50, 712-720.
59. Oliviero, A., Strens, L. H., Di Lazzaro, V., Tonali, P. A., and Brown, P. (2003). Persistent effects of high frequency repetitive TMS on the coupling between motor areas in the human. Exp. Brain Res. 149, 107-113.
60. O'Shea, J., Johansen-Berg, H., Trief, D., Gobel, S., and Rushworth, M. F. (2007). Functionally specific reorganization in human premotor cortex. Neuron 54, 479-490.
61. Pascual-Leone, A., Houser, C. M., Reese, K., Shotland, L. I., Grafman, J., Sato, S., Valls-Sole, J., Brasil-Neto, J. P., Wassermann, E. M., Cohen, L. G., Hallett, M. (1993). Safety of rapid-rate transcranial magnetic stimulation in normal volunteers. Electroencephalogr Clin Neurophysiol 89, 120-130.
62. Pascual-Leone, A., Valls-Sole, J., Wassermann, E. M., and Hallett, M. (1994). Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 117(Pt 4), 847-858.
63. Paus, T., Castro-Alamancos, M. A., and Petrides, M. (). Cortico-cortical connectivity of the human middorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. Eur. J. Neurosci. 14, 1405-1411.
64. Paus, T., Sipila, P. K., and Strafella, A. P. (2001b). Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study. J. Neurophysiol. 86, 1983-1990.
65. Paus, T., Jech, R., Thompson, C. J., Comeau, R., Peters, T., and Evans, A. C. (1997). Transcranial magnetic stimulation during positron emission tomography: a new method for studying connectivity of the human cerebral cortex. J. Neurosci. 17, 3178-3184.
66. Priori, A. (2003). Brain polarization in humans: a reappraisal of an old tool for prolonged non-invasive modulation of brain excitability. Clin Neurophysiol 114, 589-595.
67. Rossi, S., Hallett, M., Rossini, P. M., and Pascual-Leone, A. (2009). Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 120, 2008-2039.
68. Rossini, P. M., and Rossi, S. (2007). Transcranial magnetic stimulation: diagnostic, therapeutic, and research potential. Neurology 68, 484-488.
69. Rudiak, D., and Marg, E. (1994). Finding the depth of magnetic brain stimulation: a re-evaluation. Electroencephalogr Clin Neurophysiol 93, 358-371.
70. Ruff, C. C., Blankenburg, F., Bjoertomt, O., Bestmann, S., Freeman, E., Haynes, J. D., Rees, G., Josephs, O., Deichmann, R., and Driver, J. (2006). Concurrent TMS-fMRI and psychophysics reveal frontal influences on human retinotopic visual cortex. Curr. Biol. 16, 1479-1488.
71. Sanger, T. D., Garg, R. R., and Chen, R. (2001). Interactions between two different inhibitory systems in the human motor cortex. J. Physiol. 530, 307-317.
72. Shergill, S. S., Brammer, M. J., Williams, S. C., Murray, R. M., and McGuire, P. K. (2000). Mapping auditory Hallucinations in schizophrenia using functional magnetic resonance imaging. Arch. Gen. Psychiatry 57, 1033-1038.
73. Sibon, I., Strafella, A. P., Gravel, P., Ko, J. H., Booij, L., Soucy, J. P., Leyton, M., Diksic, M., and Benkelfat, C. (2007). Acute prefrontal cortex TMS in healthy volunteers: effects on brain 11C-alphaMtrp trapping. Neuroimage 34, 1658-1664.
74. Siebner, H. R., Willoch, F., Peller, M., Auer, C., Boecker, H., Conrad, B., and Bartenstein, P. (1998). Imaging brain activation induced by long trains of repetitive transcranial magnetic stimulation. Neuroreport 9, 943-948.
75. Silvanto, J., Walsh, V., and Cowey, A. (2009). Abnormal functional connectivity between ipsilesional V5/MT+ and contralesional striate cortex (V1) in blindsight. Exp. Brain Res. 193, 645-650.
76. Sommer, I. E., Diederen, K. M., Blom, J. D., Willems, A., Kushan, L., Slotema, K., Boks, M. P., Daalman, K., Hoek, H. W., Neggers, S. F., and Kahn, R. S. (2008). Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131, 3169-3177.
77. Speer, A. M., Kimbrell, T. A., Wassermann, E. M. J. D. R., Willis, M. W., Herscovitch, P., and Post, R. M. (2000). Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol. Psychiatry 48, 1133-1141.
78. Stagg, C. J., O'Shea, J., Kincses, Z. T., Woolrich, M., Matthews, P. M., and Johansen-Berg, H. (2009). Modulation of movement-associated cortical activation by transcranial direct current stimulation. Eur. J. Neurosci. 30, 1412-1423.
79. Strafella, A. P., Ko, J. H., Grant, J., Fraraccio, M., and Monchi, O. (2005). Corticostriatal functional interactions in Parkinson's disease: a rTMS/[11C] raclopride PET study. Eur. J. Neurosci. 22, 2946-2952.
80. Strafella, A. P., Paus, T., Barrett, J., and Dagher, A. (2001). Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J. Neurosci. 21, RC157.
81. Strafella, A. P., Paus, T., Fraraccio, M., and Dagher, A. (2003). Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain 126, 2609-2615.
82. Strens, L. H., Oliviero, A., Bloem, B. R., Gerschlager, W., Rothwell, J. C., and Brown, P. (2002). The effects of subthreshold 1 Hz repetitive TMS on cortico-cortical and interhemispheric coherence. Clin. Neurophysiol. 113, 1279-1285.
83. Terao, Y., Fukuda, H., Ugawa, Y., Hikosaka, O., Hanajima, R., Furubayashi, T., Sakai, K., Miyauchi, S., Sasaki, Y., and Kanazawa, I. (1998). Visualization of the information flow through human oculomotor cortical regions by transcranial magnetic stimulation. J. Neurophysiol. 80, 936-946.
84. Thut, G., Northoff, G., Ives, J. R., Kamitani, Y., Pfennig, A., Kampmann, F., Schomer, D. L., and Pascual-Leone, A. (2003). Effects of single-pulse transcranial magnetic stimulation (TMS) on functional brain activity: a combined event-related TMS and evoked potential study. Clin. Neurophysiol. 114, 2071-2080.
85. Tokimura, H., Tokimura, Y., Oliviero, A., Asakura, T., and Rothwell, J. C. (1996). Speech-induced changes in corticospinal excitability. Ann. Neurol. 40, 628-634.
86. Valentin, A., Arunachalam, R., Mesquita-Rodrigues, A., Garcia Seoane, J. J., Richardson, M. P., Mills, K. R., and Alarcon, G. (2008). Late EEG responses triggered by transcranial magnetic stimulation (TMS) in the evaluation of focal epilepsy. Epilepsia 49, 470-480.
87. Walsh, V., and Rushworth, M. (1999). A primer of magnetic stimulation as a tool for neuropsychology. Neuropsychologia 37, 125-135.
88. Wassermann, E. M. (1998). Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalogr. Clin. Neurophysiol. 108, 1-16.
89. Wittenberg, G. F., Werhahn, K. J., Wassermann, E. M., Herscovitch, P., and Cohen, L. G. (2004). Functional connectivity between somatosensory and visual cortex in early blind humans. Eur. J. Neurosci. 20, 1923-1927.
90. Zangaladze, A., Epstein, C. M., Grafton, S. T., and Sathian, K. (1999). Involvement of visual cortex in tactile discrimination of orientation. Nature 401, 587-590.