Pancreatic β-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency

FASEB Journal

Volumn 25, Issue 6, 2011, Pages 1887-1893

  Kavaler, Sarah ^a   Morinaga, Hidetaka ^b   Jih, Alice ^a   Fan, WuQiang ^b   Hedlund, Maria ^b,c,d   Varki, Ajit ^b,c,d   Kim, Jane J ^a,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University of California San Diego   (United States)

^e RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

Diabetes; Pancreatic islet; Sialic acid

Indexed keywords

CYTIDINE PHOSPHATE; GLUCOSE; INSULIN; N ACETYLNEURAMINIC ACID; N ACETYLNEURAMINIC ACID HYDROXYLASE; SIALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL SIZE; CYTIDINE MONOPHOSPHATE N ACETYLNEURAMINIC ACID HYDROXYLASE DEFICIENCY; DISEASE ASSOCIATION; DISEASE EXACERBATION; ENZYME DEFICIENCY; FASTING HYPERGLYCEMIA; GENE DELETION; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN RESPONSE; LIPID DIET; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ARGININE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY FATS; GLUCOSE; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MICE, OBESE; MIXED FUNCTION OXYGENASES; MUTATION; OBESITY;

MAMMALIA; MUS; PRIMATES;

EID: 79957893186     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-175281     Document Type: Article

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