Supercritical fluid extraction coupled with solvent-less spray collection mode for rapid separation of indirubin and tryptanthrin from folium isatidis

Separation Science and Technology

Volumn 46, Issue 6, 2011, Pages 972-977

  Chen, Hsing Jung ^a   Tsao, Hsin Hsin ^b   Lo, Jiunn Guang ^c   Chiu, Kong Hwa ^d   Jen, Jen Fon ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Folium isatidis; Indirubin; Supercritical fluid extraction; Tryptanthrin

Indexed keywords

ENVIRONMENTALLY-FRIENDLY; FOLIUM ISATIDIS; HERBAL MEDICINES; INDIRUBIN; PROCESS TIME; RAPID SEPARATION; SUPER-CRITICAL; SUPERCRITICAL CARBON DIOXIDES; TRYPTANTHRIN; TWO-PUMP;

ACETONITRILE; CARBON DIOXIDE; EFFLUENT TREATMENT; EXTRACTION; ORGANIC SOLVENTS; SOLVENTS; SUPERCRITICAL FLUIDS;

SUPERCRITICAL FLUID EXTRACTION;

EID: 79957879626     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496395.2010.537725     Document Type: Article

References (26)

1. Wang, X.; Jia, W.; Zhao, A.; Wang, X. (2006) Anti-influenza agents from plants and traditional chinese medicine. Phytother. Res., 20: 335.
2. Fang, J.G.; Hu, Y.; Tang, J.; Wang, W.Q.; Yang, Z.Q. (2005) Antiviral effect of Folium isatidis on herpes simplex virus type I. Zhongguo Zhong Yao Za Zhi, 30: 1343.
3. Lau, T.F.; Leung, P.C.; Wong, E.L.Y.; Fong, C.; Cheng, K.F.; Zhang, S.C.; Lam, C.W.K.; Wong, V.; Choy, K.M.; Ko, W.M. (2005) Using herbal medicine as a means of prevention experience during the SARS crisis. Am. J. Chin. Med., 33: 345.
4. Kunikata, T.; Tatefuji, T.; Aga, H.; Iwaki, K.; Ikeda, M.; Kurimoto, M. (2000) Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur. J. Pharmacol., 410: 93.
5. Hoessel, R.; Leclerc, S.; Endicott, J.A.; Nobel, M.E.M.; Lawrie, A.; Tunnah, P.; Leost, M.; Damiens, E.; Marie, D.; Marko, D.; Niederberger, E.; Tang, W.; Eisenbrand, G.; Meijer, L. (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat. Cell Biol., 1: 60.
6. Marko, D.; Schätzle, S.; Friedel, A.; Genzlinger, A.; Zankl, H.; Meijer, L.; Eisenbrand, G. (2001) Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. Br. J. Cancer, 84: 283.
7. Leclerc, S.; Garnier, M.; Hoessel, R.; Marko, D.; Bibb, J.A.; Snyder, G.L.; Greengard, P.; Biernat, J.; Wu, Y.Z.; Mandelkow, E.M.; Eisenbrand, G.; Meijer, L. (2001) Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J. Biol. Chem., 276: 251.
8. Eisenbrand, G.; Hippe, F.; Jakobs, S.; Muehlbeyer, S. (2004) Molecular mechanisms of indirubin and its derivatives: Novel anticancer molecules with their origin in traditional Chinese phytomedicine. J. Cancer Res. Clin. Oncol., 130: 627.
9. Adachi, J.; Mori, Y.; Matsui, S.; Takigami, H.; Fujino, J.; Kitagawa, H.; Miller, III. C.A.; Kato, T.; Saeki, K.; Matsuda, T. (2001) Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J. Biol. Chem., 276: 31475.
10. Guengerich, F.P.; Martin, M.V.; McCormick, W.A. (2004) Aryl hydrocarbon receptor response to indigoids in vitro and in vivo. Arch. Biochem. Biophys., 423: 309.
11. Suzuki, K.; Adachi, R.; Hirayama, A.; Watanabe, H.; Otani, S.; Watanabe, Y.; Kasahara, T. (2005) Indirubin, a Chinese antileukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells. Br. J. Haematol., 130: 681.
12. Ishihara, T.; Kohno, K.; Ushio, S.; Iwaki, K.; Ikeda, M.; Kurimoto, M. (2000) Tryptanthrin inhibits nitric oxide and prostaglandin E synthesis by murine macrophages. Eur. J. Pharmacol., 407: 197.
13. Motoki, T.; Takami, Y.; Yagi, Y.; Tai, A.; Yamamoto, I.; Gohda, E. (2005) Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin. Biol. Pharm. Bull., 28: 260.
14. Krivogorsky, B.; Grundt, P.; Yolken, R.; Jones-Brando, L. (2008) Inhibition of toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob. Agents Chemother., 52: 4466.
15. Deng, X.; Gao, G.; Zheng, S.; Li, F. (2008) Qualitative and quantitative analysis of flavonoids in the leaves of Isatis indigatica Fort. By ultra-performance liquid chromatography with PDA and electrospray ionization tandem mass spectrometry detection. J. Pharm. Biomed. Anal., 48: 562.
16. Zou, P.; Hong, Y.; Koh, H.L. (2005) Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis. J. Pharm. Biomed. Anal., 38: 514.
17. Dong, J.E.; Gong, M.G.; Liang, Z.S.; Wang, S.Y. (2008) Effect of drying method and extracting temperature on contents of bioactive constituents in Radix Isatidis and Folium Isatidis. Chin. Tradit. Herbal Drugs, 39: 111.
18. Oberthur, C.; Hamburger, M. (2004) Tryptanthrin content in Isatis/tinctoria leaves-a comparative study of selected strains and post-harvest treatments. Planta Med., 70: 642.
19. Wang, Z.; Mehdi, A.K.; Taylor, L.T. (2004) Air/light-free hyphenated Extraction/analysis system: Supercritical fluid extraction on-line coupled with liquid chromatography-UV absorbance/electrospray mass spectrometry for the determination of hyperforin and its degradation products in hypericum pertoratum. Anal. Chem., 76: 6771.
20. Huie, C.W. (2002) A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Anal. Bioanal. Chem., 373: 23.
21. Liu, C.T.; Wu, C.Y.; Weng, Y.M.; Tseng, C.Y. (2005) Ultrasoundassisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang. J. Ethnopharmacol., 99: 293.
22. Li, P.; Li, S.P.; Fu, C.M.; Kan, K.W.; Wang, Y.T. (2004) Pressurized solvent extraction in quality control of Chinese herb. Zhong Yao Za Zhi, 29: 723.
23. Fahmy, T.M.; Paulaitis, M.E.; Johnson, D.M.; Mcnally, E.P. (1993) Modifier effects in the supercritical fluid extraction of solutes from clay, soil, and plant materials. Anal. Chem., 65: 1462.
24. Li, L.; Wu, X.F. (1995) Determination 2,4 (1H,2H)-quinozoline-dione in Radix Isatidis and Folium Isatidis by SFE-HPLC. Chin. J. Pharm. Anal., 15: 49.
25. Danz, H.; Stoyanova, S.; Wippich, P.; Brattstrom, A.; Hamburger, M. (2001) Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Med., 67: 411.
26. Recio, M.C.; Cerdá-Nicolás, M.; Hamburger, M.; Rios, J.L. (2006) Anti-inflammatory and anti-allergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin. Planta Med., 72: 539.